Apathetic symptoms and white matter integrity after traumatic brain injury

Primary objective The aim of the study was twofold. First, to study the relationship among apathy in the long term, initial clinical measures, and standard outcome scores after traumatic brain injury (TBI). Second, to describe white matter integrity correlates of apathy symptoms. Research Design Cor...

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Autores: Navarro-Main, Blanca, Castaño León, Ana María, Hilario Barrio, Amaya, Lagares, A, Albarrán Periáñez, José David, Ríos Lago, Marcos, Inertia Group Collaborators
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:inglés
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/31235
Acceso en línea:https://hdl.handle.net/20.500.14468/31235
Access Level:acceso abierto
Palabra clave:3213.08 Neurocirugía
traumatic brain injury
white matter
DT
Bayesian networks
apathy
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spelling Apathetic symptoms and white matter integrity after traumatic brain injuryNavarro-Main, BlancaCastaño León, Ana MaríaHilario Barrio, AmayaLagares, AAlbarrán Periáñez, José DavidRíos Lago, MarcosInertia Group Collaborators3213.08 Neurocirugíatraumatic brain injurywhite matterDTBayesian networksapathyPrimary objective The aim of the study was twofold. First, to study the relationship among apathy in the long term, initial clinical measures, and standard outcome scores after traumatic brain injury (TBI). Second, to describe white matter integrity correlates of apathy symptoms. Research Design Correlational study. Methods and Procedures: Correlation and Bayesian networks analyses were performed in a sample of 40 patients with moderate to severe TBI in order to identify the relationship among clinical variables, functionality, and apathy. A diffusion tensor imaging study was developed in 25 participants to describe correlations between fractional anisotropy (FA) measures and apathetic symptoms. Main outcomes and results Correlation analysis revealed associations between pairs of variables as apathy in the long term and functional score at discharge from hospital. Bayesian network illustrated the relevant role of axonal injury mediating the relationship between apathy and initial clinical variables. FA in the superior longitudinal fasciculus, the inferior longitudinal fasciculus, and the internal capsule were negatively correlated with apathy measures. Widespread brain areas showed positive correlations between FA and apathy. Conclusions These results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase.Taylor & FrancisFundación Mapfre, Beca Ignacio Larramendie-Spacio UNED20252025-12-1920212021-08-0620212021-08-06journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/31235reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/312352026-06-06T12:38:31Z
dc.title.none.fl_str_mv Apathetic symptoms and white matter integrity after traumatic brain injury
title Apathetic symptoms and white matter integrity after traumatic brain injury
spellingShingle Apathetic symptoms and white matter integrity after traumatic brain injury
Navarro-Main, Blanca
3213.08 Neurocirugía
traumatic brain injury
white matter
DT
Bayesian networks
apathy
title_short Apathetic symptoms and white matter integrity after traumatic brain injury
title_full Apathetic symptoms and white matter integrity after traumatic brain injury
title_fullStr Apathetic symptoms and white matter integrity after traumatic brain injury
title_full_unstemmed Apathetic symptoms and white matter integrity after traumatic brain injury
title_sort Apathetic symptoms and white matter integrity after traumatic brain injury
dc.creator.none.fl_str_mv Navarro-Main, Blanca
Castaño León, Ana María
Hilario Barrio, Amaya
Lagares, A
Albarrán Periáñez, José David
Ríos Lago, Marcos
Inertia Group Collaborators
author Navarro-Main, Blanca
author_facet Navarro-Main, Blanca
Castaño León, Ana María
Hilario Barrio, Amaya
Lagares, A
Albarrán Periáñez, José David
Ríos Lago, Marcos
Inertia Group Collaborators
author_role author
author2 Castaño León, Ana María
Hilario Barrio, Amaya
Lagares, A
Albarrán Periáñez, José David
Ríos Lago, Marcos
Inertia Group Collaborators
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Mapfre, Beca Ignacio Larramendi
e-Spacio UNED
dc.subject.none.fl_str_mv 3213.08 Neurocirugía
traumatic brain injury
white matter
DT
Bayesian networks
apathy
topic 3213.08 Neurocirugía
traumatic brain injury
white matter
DT
Bayesian networks
apathy
description Primary objective The aim of the study was twofold. First, to study the relationship among apathy in the long term, initial clinical measures, and standard outcome scores after traumatic brain injury (TBI). Second, to describe white matter integrity correlates of apathy symptoms. Research Design Correlational study. Methods and Procedures: Correlation and Bayesian networks analyses were performed in a sample of 40 patients with moderate to severe TBI in order to identify the relationship among clinical variables, functionality, and apathy. A diffusion tensor imaging study was developed in 25 participants to describe correlations between fractional anisotropy (FA) measures and apathetic symptoms. Main outcomes and results Correlation analysis revealed associations between pairs of variables as apathy in the long term and functional score at discharge from hospital. Bayesian network illustrated the relevant role of axonal injury mediating the relationship between apathy and initial clinical variables. FA in the superior longitudinal fasciculus, the inferior longitudinal fasciculus, and the internal capsule were negatively correlated with apathy measures. Widespread brain areas showed positive correlations between FA and apathy. Conclusions These results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-08-06
2021
2021-08-06
2025
2025-12-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/31235
url https://hdl.handle.net/20.500.14468/31235
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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