Urinary Arsenic Speciation in Children and Pregnant Women from Spain

Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero an...

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Autores: Signes Pastor, Antonio J., Carey, Manus, Vioque, Jesús, Navarrete Muñoz, Eva Maria, Rodríguez Dehli, Cristina, Tardón, Adonina, Zubero, Begoña, Santa Marina, Loreto, Vrijheid, Martine, Casas, Maribel, Llop, Sabrina, Gonzalez Palacios, Sandra, Meharg, Andrew A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/113436
Acesso em linha:https://hdl.handle.net/2445/113436
Access Level:acceso abierto
Palavra-chave:Embaràs
Infants
Arsènic
Embarassades
Pregnancy
Children
Arsenic
Pregnant women
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spelling Urinary Arsenic Speciation in Children and Pregnant Women from SpainSignes Pastor, Antonio J.Carey, ManusVioque, JesúsNavarrete Muñoz, Eva MariaRodríguez Dehli, CristinaTardón, AdoninaZubero, BegoñaSanta Marina, LoretoVrijheid, MartineCasas, MaribelLlop, SabrinaGonzalez Palacios, SandraMeharg, Andrew A.EmbaràsInfantsArsènicEmbarassadesPregnancyChildrenArsenicPregnant womenInorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 mug/l (arsenobetaine-AsB), 3.97 mug/l (dimethylarsinic acid-DMA), 0.44 mug/l (monomethylarsonic acid-MMA) and 0.35 mug/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.Springer2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/113436Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1007/s12403-016-0225-7Exposure & Health, 2017, vol. 9, num. 2, p. 105-111http://dx.doi.org/10.1007/s12403-016-0225-7info:eu-repo/grantAgreement/EC/FP7/622096info:eu-repo/grantAgreement/EC/FP7/282957cc by (c) Signes et al., 2016http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1134362026-05-27T06:46:51Z
dc.title.none.fl_str_mv Urinary Arsenic Speciation in Children and Pregnant Women from Spain
title Urinary Arsenic Speciation in Children and Pregnant Women from Spain
spellingShingle Urinary Arsenic Speciation in Children and Pregnant Women from Spain
Signes Pastor, Antonio J.
Embaràs
Infants
Arsènic
Embarassades
Pregnancy
Children
Arsenic
Pregnant women
title_short Urinary Arsenic Speciation in Children and Pregnant Women from Spain
title_full Urinary Arsenic Speciation in Children and Pregnant Women from Spain
title_fullStr Urinary Arsenic Speciation in Children and Pregnant Women from Spain
title_full_unstemmed Urinary Arsenic Speciation in Children and Pregnant Women from Spain
title_sort Urinary Arsenic Speciation in Children and Pregnant Women from Spain
dc.creator.none.fl_str_mv Signes Pastor, Antonio J.
Carey, Manus
Vioque, Jesús
Navarrete Muñoz, Eva Maria
Rodríguez Dehli, Cristina
Tardón, Adonina
Zubero, Begoña
Santa Marina, Loreto
Vrijheid, Martine
Casas, Maribel
Llop, Sabrina
Gonzalez Palacios, Sandra
Meharg, Andrew A.
author Signes Pastor, Antonio J.
author_facet Signes Pastor, Antonio J.
Carey, Manus
Vioque, Jesús
Navarrete Muñoz, Eva Maria
Rodríguez Dehli, Cristina
Tardón, Adonina
Zubero, Begoña
Santa Marina, Loreto
Vrijheid, Martine
Casas, Maribel
Llop, Sabrina
Gonzalez Palacios, Sandra
Meharg, Andrew A.
author_role author
author2 Carey, Manus
Vioque, Jesús
Navarrete Muñoz, Eva Maria
Rodríguez Dehli, Cristina
Tardón, Adonina
Zubero, Begoña
Santa Marina, Loreto
Vrijheid, Martine
Casas, Maribel
Llop, Sabrina
Gonzalez Palacios, Sandra
Meharg, Andrew A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embaràs
Infants
Arsènic
Embarassades
Pregnancy
Children
Arsenic
Pregnant women
topic Embaràs
Infants
Arsènic
Embarassades
Pregnancy
Children
Arsenic
Pregnant women
description Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 mug/l (arsenobetaine-AsB), 3.97 mug/l (dimethylarsinic acid-DMA), 0.44 mug/l (monomethylarsonic acid-MMA) and 0.35 mug/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/113436
url https://hdl.handle.net/2445/113436
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1007/s12403-016-0225-7
Exposure & Health, 2017, vol. 9, num. 2, p. 105-111
http://dx.doi.org/10.1007/s12403-016-0225-7
info:eu-repo/grantAgreement/EC/FP7/622096
info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.none.fl_str_mv cc by (c) Signes et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Signes et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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