Technological and biological aspects of polymeric nanocapsules for the design of new nanovaccines
The main goals of this thesis have been i) to develop new methods to prepare on-demand nanocapsules, with interest in the vaccination field, and ii) to understand the impact of their design on the interaction with biological systems. Specifically, new nanocapsules with tunable particle size and with...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/18255 |
| Acceso en línea: | http://hdl.handle.net/10347/18255 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos Materias::Investigación::24 Ciencias de la vida::2412 Inmunología::241210 Vacunas |
| Sumario: | The main goals of this thesis have been i) to develop new methods to prepare on-demand nanocapsules, with interest in the vaccination field, and ii) to understand the impact of their design on the interaction with biological systems. Specifically, new nanocapsules with tunable particle size and with one or multiple polymeric layers were engineered. In this regard, the potential of novel chitosan/dextran sulfate bilayer nanocapsules to protect and control the release of the associated antigen was proved. Besides, chitosan and inulin nanocapsules with different particle sizes were developed, and the influence of their size and polymeric shell was evaluated in terms of interaction with immune cells, toxicity, dissemination and lymphatic drainage. |
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