NF-κB signaling pathways: role in nervous system physiology and pathology

Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor- κB (NF-κB). The activity of this pathway leads to the nuclear t...

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Authors: Tasheva, Stefka Mincheva, Soler i Tatché, Rosa Ma.
Format: article
Status:Versión aceptada para publicación
Publication Date:2013
Country:España
Institution:Universitat de Lleida (UdL)
Repository:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/62850
Online Access:https://doi.org/10.1177/1073858412444007
http://hdl.handle.net/10459.1/62850
Access Level:Open access
Keyword:NF-kB
Neuronal survival
Neurotrophic
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spelling NF-κB signaling pathways: role in nervous system physiology and pathologyTasheva, Stefka MinchevaSoler i Tatché, Rosa Ma.NF-kBNeuronal survivalNeurotrophicIntracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor- κB (NF-κB). The activity of this pathway leads to the nuclear translocation of the NF-κB transcription factors and the regulation of anti-apoptotic gene expression. Different stimuli can activate the pathway through different intracellular cascades (canonical, non-canonical, and atypical), contributing to the translocation of specific dimers of the NF-κB transcription factors, and each of these dimers can regulate the transcription of different genes. Recent studies have shown that the activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These apparent contradictory effects depend on conditions such as the pathway stimuli, the origin of the cells, or the cellular context. In the present review, the authors summarize these findings and discuss their significance with respect to survival or death in the nervous system.This work was supported by grants to RMS from Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias (PI080267/PI1101047), and Consolider-Ingenio 2010 (CSD2007-00020, Ministerio de Ciencia e Innovación), and by the Generalitat de Catalunya (Suport Grups de Recerca Emergents) 2009SGR740. SMT holds a fellowship from Consolider-Ingenio 2010 (CSD2007-00020).Sage2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1177/1073858412444007http://hdl.handle.net/10459.1/62850reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a: https://doi.org/10.1177/1073858412444007Neuroscientist, 2013, vol. 19, num. 2, p. 175-194(c) Tasheva, Soler, 2012info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/628502026-06-24T12:42:17Z
dc.title.none.fl_str_mv NF-κB signaling pathways: role in nervous system physiology and pathology
title NF-κB signaling pathways: role in nervous system physiology and pathology
spellingShingle NF-κB signaling pathways: role in nervous system physiology and pathology
Tasheva, Stefka Mincheva
NF-kB
Neuronal survival
Neurotrophic
title_short NF-κB signaling pathways: role in nervous system physiology and pathology
title_full NF-κB signaling pathways: role in nervous system physiology and pathology
title_fullStr NF-κB signaling pathways: role in nervous system physiology and pathology
title_full_unstemmed NF-κB signaling pathways: role in nervous system physiology and pathology
title_sort NF-κB signaling pathways: role in nervous system physiology and pathology
dc.creator.none.fl_str_mv Tasheva, Stefka Mincheva
Soler i Tatché, Rosa Ma.
author Tasheva, Stefka Mincheva
author_facet Tasheva, Stefka Mincheva
Soler i Tatché, Rosa Ma.
author_role author
author2 Soler i Tatché, Rosa Ma.
author2_role author
dc.subject.none.fl_str_mv NF-kB
Neuronal survival
Neurotrophic
topic NF-kB
Neuronal survival
Neurotrophic
description Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor- κB (NF-κB). The activity of this pathway leads to the nuclear translocation of the NF-κB transcription factors and the regulation of anti-apoptotic gene expression. Different stimuli can activate the pathway through different intracellular cascades (canonical, non-canonical, and atypical), contributing to the translocation of specific dimers of the NF-κB transcription factors, and each of these dimers can regulate the transcription of different genes. Recent studies have shown that the activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These apparent contradictory effects depend on conditions such as the pathway stimuli, the origin of the cells, or the cellular context. In the present review, the authors summarize these findings and discuss their significance with respect to survival or death in the nervous system.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1177/1073858412444007
http://hdl.handle.net/10459.1/62850
url https://doi.org/10.1177/1073858412444007
http://hdl.handle.net/10459.1/62850
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1177/1073858412444007
Neuroscientist, 2013, vol. 19, num. 2, p. 175-194
dc.rights.none.fl_str_mv (c) Tasheva, Soler, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Tasheva, Soler, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage
publisher.none.fl_str_mv Sage
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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