Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study

The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate o...

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Autores: Gorina-Careta, Natàlia, Kurkela, Jari L. O., Hämäläinen, Jarmo, Astikainen, Piia, Escera i Micó, Carles
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/207332
Acesso em linha:https://hdl.handle.net/2445/207332
Access Level:acceso abierto
Palavra-chave:Neuroplasticitat
Neurociència cognitiva
Psicoacústica
Neuroplasticity
Cognitive neuroscience
Psychoacoustic
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spelling Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) studyGorina-Careta, NatàliaKurkela, Jari L. O.Hämäläinen, JarmoAstikainen, PiiaEscera i Micó, CarlesNeuroplasticitatNeurociència cognitivaPsicoacústicaNeuroplasticityCognitive neurosciencePsychoacousticThe frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N = 19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the highfrequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding.Elsevier B.V.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/207332Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2021.117866Neuroimage, 2021, vol. 231, 117866https://doi.org/10.1016/j.neuroimage.2021.117866cc-by-nc-nd (c) Gorina-Careta, N. et al., 2021http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2073322026-05-27T06:46:51Z
dc.title.none.fl_str_mv Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
title Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
spellingShingle Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
Gorina-Careta, Natàlia
Neuroplasticitat
Neurociència cognitiva
Psicoacústica
Neuroplasticity
Cognitive neuroscience
Psychoacoustic
title_short Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
title_full Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
title_fullStr Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
title_full_unstemmed Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
title_sort Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study
dc.creator.none.fl_str_mv Gorina-Careta, Natàlia
Kurkela, Jari L. O.
Hämäläinen, Jarmo
Astikainen, Piia
Escera i Micó, Carles
author Gorina-Careta, Natàlia
author_facet Gorina-Careta, Natàlia
Kurkela, Jari L. O.
Hämäläinen, Jarmo
Astikainen, Piia
Escera i Micó, Carles
author_role author
author2 Kurkela, Jari L. O.
Hämäläinen, Jarmo
Astikainen, Piia
Escera i Micó, Carles
author2_role author
author
author
author
dc.subject.none.fl_str_mv Neuroplasticitat
Neurociència cognitiva
Psicoacústica
Neuroplasticity
Cognitive neuroscience
Psychoacoustic
topic Neuroplasticitat
Neurociència cognitiva
Psicoacústica
Neuroplasticity
Cognitive neuroscience
Psychoacoustic
description The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N = 19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the highfrequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207332
url https://hdl.handle.net/2445/207332
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2021.117866
Neuroimage, 2021, vol. 231, 117866
https://doi.org/10.1016/j.neuroimage.2021.117866
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Gorina-Careta, N. et al., 2021
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Gorina-Careta, N. et al., 2021
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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