Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Corominas Castiñeira, Roser; Yang, Xinping; Lin, Guan Ning; Kang, Shuli; Shen, Yun; Ghamsari, Lila; Broly, Martin; Rodriguez, Maria; Tam, Stanley; Trigg, Shelly A.; Fan, Changyu; Yi, Song; Tasan, Murat; Lemmens, Irma; Kuang, Xingyan; Zhao, Nan; Malhotra, Dheeraj; Michaelson, Jacob J.; Vacic, Vladimir; Calderwood, Michael A.; Roth, Frederick P.; Tavernier, Jan; Horvath, Steve; Salehi-Ashtiani, Kourosh; Korkin, Dmitry; Sebat, Jonathan; Hill, David E.; Hao, Tong; Vidal, Marc; Iakoucheva, Lilia M.

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, ca...

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Detalhes bibliográficos
Autores:	Corominas Castiñeira, Roser, Yang, Xinping, Lin, Guan Ning, Kang, Shuli, Shen, Yun, Ghamsari, Lila, Broly, Martin, Rodriguez, Maria, Tam, Stanley, Trigg, Shelly A., Fan, Changyu, Yi, Song, Tasan, Murat, Lemmens, Irma, Kuang, Xingyan, Zhao, Nan, Malhotra, Dheeraj, Michaelson, Jacob J., Vacic, Vladimir, Calderwood, Michael A., Roth, Frederick P., Tavernier, Jan, Horvath, Steve, Salehi-Ashtiani, Kourosh, Korkin, Dmitry, Sebat, Jonathan, Hill, David E., Hao, Tong, Vidal, Marc, Iakoucheva, Lilia M.
Tipo de documento:	artigo
Estado:	Versión aceptada para publicación
Data de publicação:	2014
País:	España
Recursos:	Universidad de Barcelona
Repositório:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/176481
Acesso em linha:	https://hdl.handle.net/2445/176481
Access Level:	Acceso aberto
Palavra-chave:	Autisme Proteïnes Genètica Autism Proteins Genetics

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spelling	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autismCorominas Castiñeira, RoserYang, XinpingLin, Guan NingKang, ShuliShen, YunGhamsari, LilaBroly, MartinRodriguez, MariaTam, StanleyTrigg, Shelly A.Fan, ChangyuYi, SongTasan, MuratLemmens, IrmaKuang, XingyanZhao, NanMalhotra, DheerajMichaelson, Jacob J.Vacic, VladimirCalderwood, Michael A.Roth, Frederick P.Tavernier, JanHorvath, SteveSalehi-Ashtiani, KouroshKorkin, DmitrySebat, JonathanHill, David E.Hao, TongVidal, MarcIakoucheva, Lilia M.AutismeProteïnesGenèticaAutismProteinsGeneticsIncreased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. Here we introduce a new interactome mapping approach by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors. The Autism Spliceform Interaction Network reveals that almost half of the detected interactions and about 30% of the newly identified interacting partners represent contribution from splicing variants, emphasizing the importance of isoform networks. Isoform interactions greatly contribute to establishing direct physical connections between proteins from the de novo autism CNVs. Our findings demonstrate the critical role of spliceform networks for translating genetic knowledge into a better understanding of human diseases.Nature Publishing Group2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/176481Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1038/ncomms4650Nature Communications, 2014, vol. 5, num. 3650https://doi.org/10.1038/ncomms4650(c) Corominas Castiñeira, Roser et al., 2014info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1764812026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
title	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
spellingShingle	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism Corominas Castiñeira, Roser Autisme Proteïnes Genètica Autism Proteins Genetics
title_short	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
title_full	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
title_fullStr	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
title_full_unstemmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
title_sort	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
dc.creator.none.fl_str_mv	Corominas Castiñeira, Roser Yang, Xinping Lin, Guan Ning Kang, Shuli Shen, Yun Ghamsari, Lila Broly, Martin Rodriguez, Maria Tam, Stanley Trigg, Shelly A. Fan, Changyu Yi, Song Tasan, Murat Lemmens, Irma Kuang, Xingyan Zhao, Nan Malhotra, Dheeraj Michaelson, Jacob J. Vacic, Vladimir Calderwood, Michael A. Roth, Frederick P. Tavernier, Jan Horvath, Steve Salehi-Ashtiani, Kourosh Korkin, Dmitry Sebat, Jonathan Hill, David E. Hao, Tong Vidal, Marc Iakoucheva, Lilia M.
author	Corominas Castiñeira, Roser
author_facet	Corominas Castiñeira, Roser Yang, Xinping Lin, Guan Ning Kang, Shuli Shen, Yun Ghamsari, Lila Broly, Martin Rodriguez, Maria Tam, Stanley Trigg, Shelly A. Fan, Changyu Yi, Song Tasan, Murat Lemmens, Irma Kuang, Xingyan Zhao, Nan Malhotra, Dheeraj Michaelson, Jacob J. Vacic, Vladimir Calderwood, Michael A. Roth, Frederick P. Tavernier, Jan Horvath, Steve Salehi-Ashtiani, Kourosh Korkin, Dmitry Sebat, Jonathan Hill, David E. Hao, Tong Vidal, Marc Iakoucheva, Lilia M.
author_role	author
author2	Yang, Xinping Lin, Guan Ning Kang, Shuli Shen, Yun Ghamsari, Lila Broly, Martin Rodriguez, Maria Tam, Stanley Trigg, Shelly A. Fan, Changyu Yi, Song Tasan, Murat Lemmens, Irma Kuang, Xingyan Zhao, Nan Malhotra, Dheeraj Michaelson, Jacob J. Vacic, Vladimir Calderwood, Michael A. Roth, Frederick P. Tavernier, Jan Horvath, Steve Salehi-Ashtiani, Kourosh Korkin, Dmitry Sebat, Jonathan Hill, David E. Hao, Tong Vidal, Marc Iakoucheva, Lilia M.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Autisme Proteïnes Genètica Autism Proteins Genetics
topic	Autisme Proteïnes Genètica Autism Proteins Genetics
description	Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. Here we introduce a new interactome mapping approach by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors. The Autism Spliceform Interaction Network reveals that almost half of the detected interactions and about 30% of the newly identified interacting partners represent contribution from splicing variants, emphasizing the importance of isoform networks. Isoform interactions greatly contribute to establishing direct physical connections between proteins from the de novo autism CNVs. Our findings demonstrate the critical role of spliceform networks for translating genetic knowledge into a better understanding of human diseases.
publishDate	2014
dc.date.none.fl_str_mv	2014
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/176481
url	https://hdl.handle.net/2445/176481
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1038/ncomms4650 Nature Communications, 2014, vol. 5, num. 3650 https://doi.org/10.1038/ncomms4650
dc.rights.none.fl_str_mv	(c) Corominas Castiñeira, Roser et al., 2014 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) Corominas Castiñeira, Roser et al., 2014
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	Articles publicats en revistes (Genètica, Microbiologia i Estadística) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.301603

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

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