Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study

STW 5-II has been shown to improve numerous symptoms in functional dyspepsia. To determine if the herbal medicinal product STW 5-II may improve gastric gas transit and tolerance in patients with functional dyspepsia. In a parallel, randomized, double-blinded, placebo-controlled study, a gas challeng...

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Autores: Aguilar, Ariadna|||0000-0002-2040-311X, Barber Caselles, Claudia|||0000-0003-4711-2731, Santos, Javier|||0000-0002-4798-5033, Lobo Álvarez, Beatriz|||0000-0003-3391-7125, Malagelada Prats, Carolina|||0000-0001-7097-1492, Serra Pueyo, Jordi|||0000-0003-2120-6270, Alcalá González, Luis Gerardo|||0000-0003-3247-1539
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::352146db51406a773d0590e449c0ecac
Acceso en línea:https://ddd.uab.cat/record/328084
https://dx.doi.org/urn:doi:10.1111/nmo.70123
Access Level:acceso abierto
Palabra clave:Bloating
Functional dyspepsia
Gastric gas
STW 5-II
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spelling Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 StudyAguilar, Ariadna|||0000-0002-2040-311XBarber Caselles, Claudia|||0000-0003-4711-2731Santos, Javier|||0000-0002-4798-5033Lobo Álvarez, Beatriz|||0000-0003-3391-7125Malagelada Prats, Carolina|||0000-0001-7097-1492Serra Pueyo, Jordi|||0000-0003-2120-6270Alcalá González, Luis Gerardo|||0000-0003-3247-1539BloatingFunctional dyspepsiaGastric gasSTW 5-IISTW 5-II has been shown to improve numerous symptoms in functional dyspepsia. To determine if the herbal medicinal product STW 5-II may improve gastric gas transit and tolerance in patients with functional dyspepsia. In a parallel, randomized, double-blinded, placebo-controlled study, a gas challenge test was performed in 32 patients with functional dyspepsia and bloating after 2 weeks of treatment with (a) STW 5-II and (b) placebo. The challenge test consisted of continuous infusion of gas into the stomach (100 mL/min for 15 min) with simultaneous nutrient perfusion (315 kcal for 15 min, 210 mL final volume). Gas evacuation, symptom perception, and abdominal distension were continuously registered for 90 min. Gastric gas infusion was followed by a progressive start of gas evacuation from the rectum that was significantly accelerated when patients were on STW 5-II (319 ± 81 mL after 20 min infusion start), compared to placebo (80 ± 39 mL; p = 0.015), but this difference declined during the following 90 min of gas evacuation (final gas retention 470 ± 160 and 662 ± 179, STW 5-II and placebo, respectively, p = 0.431). Gas infusion was associated with a significant rise and posterior progressive decline in abdominal symptom perception (mainly bloating) that was significantly lower in patients treated with STW 5-II (mean score increment 0.8 ± 0.4) than in patients treated with placebo (score increment 2.1 ± 0.4; p = 0.036). There were no significant differences in abdominal distension between groups. STW 5-II improves tolerance to gastric gas in patients with functional dyspepsia and may be beneficial for the treatment of gas-related abdominal symptoms like bloating. EudraCT number: 2019-003976-38 In a parallel, placebo-controlled study with direct gas infusion into the stomach, STW 5-II reduced the perception of abdominal symptoms in patients with dyspepsia complaining of bloating when compared to placebo, with a minor effect on gas transit and evacuation, and no effect on visible abdominal distension. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328084https://dx.doi.org/urn:doi:10.1111/nmo.70123reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::352146db51406a773d0590e449c0ecac2026-06-06T12:50:31Z
dc.title.none.fl_str_mv Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
title Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
spellingShingle Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
Aguilar, Ariadna|||0000-0002-2040-311X
Bloating
Functional dyspepsia
Gastric gas
STW 5-II
title_short Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
title_full Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
title_fullStr Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
title_full_unstemmed Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
title_sort Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study
dc.creator.none.fl_str_mv Aguilar, Ariadna|||0000-0002-2040-311X
Barber Caselles, Claudia|||0000-0003-4711-2731
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Malagelada Prats, Carolina|||0000-0001-7097-1492
Serra Pueyo, Jordi|||0000-0003-2120-6270
Alcalá González, Luis Gerardo|||0000-0003-3247-1539
author Aguilar, Ariadna|||0000-0002-2040-311X
author_facet Aguilar, Ariadna|||0000-0002-2040-311X
Barber Caselles, Claudia|||0000-0003-4711-2731
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Malagelada Prats, Carolina|||0000-0001-7097-1492
Serra Pueyo, Jordi|||0000-0003-2120-6270
Alcalá González, Luis Gerardo|||0000-0003-3247-1539
author_role author
author2 Barber Caselles, Claudia|||0000-0003-4711-2731
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Malagelada Prats, Carolina|||0000-0001-7097-1492
Serra Pueyo, Jordi|||0000-0003-2120-6270
Alcalá González, Luis Gerardo|||0000-0003-3247-1539
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bloating
Functional dyspepsia
Gastric gas
STW 5-II
topic Bloating
Functional dyspepsia
Gastric gas
STW 5-II
description STW 5-II has been shown to improve numerous symptoms in functional dyspepsia. To determine if the herbal medicinal product STW 5-II may improve gastric gas transit and tolerance in patients with functional dyspepsia. In a parallel, randomized, double-blinded, placebo-controlled study, a gas challenge test was performed in 32 patients with functional dyspepsia and bloating after 2 weeks of treatment with (a) STW 5-II and (b) placebo. The challenge test consisted of continuous infusion of gas into the stomach (100 mL/min for 15 min) with simultaneous nutrient perfusion (315 kcal for 15 min, 210 mL final volume). Gas evacuation, symptom perception, and abdominal distension were continuously registered for 90 min. Gastric gas infusion was followed by a progressive start of gas evacuation from the rectum that was significantly accelerated when patients were on STW 5-II (319 ± 81 mL after 20 min infusion start), compared to placebo (80 ± 39 mL; p = 0.015), but this difference declined during the following 90 min of gas evacuation (final gas retention 470 ± 160 and 662 ± 179, STW 5-II and placebo, respectively, p = 0.431). Gas infusion was associated with a significant rise and posterior progressive decline in abdominal symptom perception (mainly bloating) that was significantly lower in patients treated with STW 5-II (mean score increment 0.8 ± 0.4) than in patients treated with placebo (score increment 2.1 ± 0.4; p = 0.036). There were no significant differences in abdominal distension between groups. STW 5-II improves tolerance to gastric gas in patients with functional dyspepsia and may be beneficial for the treatment of gas-related abdominal symptoms like bloating. EudraCT number: 2019-003976-38 In a parallel, placebo-controlled study with direct gas infusion into the stomach, STW 5-II reduced the perception of abdominal symptoms in patients with dyspepsia complaining of bloating when compared to placebo, with a minor effect on gas transit and evacuation, and no effect on visible abdominal distension.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/328084
https://dx.doi.org/urn:doi:10.1111/nmo.70123
url https://ddd.uab.cat/record/328084
https://dx.doi.org/urn:doi:10.1111/nmo.70123
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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