Peptide amphiphiles for pharmaceutical applications

During the last few decades, several efforts have been made towards developing biocompatible materials. Among them, peptide amphiphiles (PAs) constitute a novel nanotechnological strategy used in the field of biomedicine since they can provide tissue- specific binding and localization. PAs possess s...

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Detalhes bibliográficos
Autores: Fuertes-Llanos, Mayra Alejandra, Gómara Elena, María José, Haro Villar, Isabel, Sánchez-López, Elena
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/380407
Acesso em linha:http://hdl.handle.net/10261/380407
https://api.elsevier.com/content/abstract/scopus_id/85171800467
Access Level:acceso abierto
Palavra-chave:Supramolecular self-assembly
Anticancer drugs
Antimicrobial activity
Drug delivery
Nanostructures
Nanotechnology
Peptide amphiphiles
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Peptide amphiphiles for pharmaceutical applicationsFuertes-Llanos, Mayra AlejandraGómara Elena, María JoséHaro Villar, IsabelSánchez-López, ElenaSupramolecular self-assemblyAnticancer drugsAntimicrobial activityDrug deliveryNanostructuresNanotechnologyPeptide amphiphileshttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesDuring the last few decades, several efforts have been made towards developing biocompatible materials. Among them, peptide amphiphiles (PAs) constitute a novel nanotechnological strategy used in the field of biomedicine since they can provide tissue- specific binding and localization. PAs possess several regions combining hydrophobic and hydrophilic areas that are able to self-assemble in aqueous media, forming different tertiary nanostructures able to interact with cellular membranes. Moreover, these molecules can be tuned by incorporating collagen, lipids, or fluorescent markers. In addition, they can also be used as carriers in order to encapsulate active compounds for drug delivery showing promising features in this area. In this review, the self-assembled structures of PAs as well as their pharmacological applications have been summarized. Furthermore, their use as drug delivery systems has been highlighted and the latest advances in this field have been reviewed.This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (Grants PID2021-122216OB-I00 and PID2021-122187NB-C32).Peer reviewedBentham Science PublishersConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/380407https://api.elsevier.com/content/abstract/scopus_id/85171800467reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCurrent Medicinal Chemistry10.2174/0929867330666230408203820Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3804072026-05-22T06:33:51Z
dc.title.none.fl_str_mv Peptide amphiphiles for pharmaceutical applications
title Peptide amphiphiles for pharmaceutical applications
spellingShingle Peptide amphiphiles for pharmaceutical applications
Fuertes-Llanos, Mayra Alejandra
Supramolecular self-assembly
Anticancer drugs
Antimicrobial activity
Drug delivery
Nanostructures
Nanotechnology
Peptide amphiphiles
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Peptide amphiphiles for pharmaceutical applications
title_full Peptide amphiphiles for pharmaceutical applications
title_fullStr Peptide amphiphiles for pharmaceutical applications
title_full_unstemmed Peptide amphiphiles for pharmaceutical applications
title_sort Peptide amphiphiles for pharmaceutical applications
dc.creator.none.fl_str_mv Fuertes-Llanos, Mayra Alejandra
Gómara Elena, María José
Haro Villar, Isabel
Sánchez-López, Elena
author Fuertes-Llanos, Mayra Alejandra
author_facet Fuertes-Llanos, Mayra Alejandra
Gómara Elena, María José
Haro Villar, Isabel
Sánchez-López, Elena
author_role author
author2 Gómara Elena, María José
Haro Villar, Isabel
Sánchez-López, Elena
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Supramolecular self-assembly
Anticancer drugs
Antimicrobial activity
Drug delivery
Nanostructures
Nanotechnology
Peptide amphiphiles
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Supramolecular self-assembly
Anticancer drugs
Antimicrobial activity
Drug delivery
Nanostructures
Nanotechnology
Peptide amphiphiles
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description During the last few decades, several efforts have been made towards developing biocompatible materials. Among them, peptide amphiphiles (PAs) constitute a novel nanotechnological strategy used in the field of biomedicine since they can provide tissue- specific binding and localization. PAs possess several regions combining hydrophobic and hydrophilic areas that are able to self-assemble in aqueous media, forming different tertiary nanostructures able to interact with cellular membranes. Moreover, these molecules can be tuned by incorporating collagen, lipids, or fluorescent markers. In addition, they can also be used as carriers in order to encapsulate active compounds for drug delivery showing promising features in this area. In this review, the self-assembled structures of PAs as well as their pharmacological applications have been summarized. Furthermore, their use as drug delivery systems has been highlighted and the latest advances in this field have been reviewed.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/380407
https://api.elsevier.com/content/abstract/scopus_id/85171800467
url http://hdl.handle.net/10261/380407
https://api.elsevier.com/content/abstract/scopus_id/85171800467
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Current Medicinal Chemistry
10.2174/0929867330666230408203820
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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