Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.

The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor&#...

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Detalles Bibliográficos
Autores: Serna, Eva, Cespedes, Cristina, Vina, Jose
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15398
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15398
Access Level:acceso abierto
Palabra clave:aryl hydrocarbon receptor
aging
physiological function
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spelling Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.Serna, EvaCespedes, CristinaVina, Josearyl hydrocarbon receptoragingphysiological functionThe vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor's role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor's main physiological functions (mediated by the modulation of gene expression) were cell regeneration, the immune reaction, intestinal homeostasis, and cell proliferation. Furthermore, it was shown that the loss of this receptor led to premature aging. This process may be caused by the dysregulation of hematopoietic stem cells, loss of glucose and lipid homeostasis, increase in inflammation, and deterioration of the brain. We conclude that the aryl hydrocarbon receptor, apart from its well-established role in xenobiotic detoxication, plays an important role in physiological functions and in the aging process. Modulation of the signaling pathway of this receptor could be a therapeutic target of interest in aging.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15398INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 16616596ISSNe: 14220067reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p153982026-06-07T16:35:31Z
dc.title.none.fl_str_mv Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
title Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
spellingShingle Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
Serna, Eva
aryl hydrocarbon receptor
aging
physiological function
title_short Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
title_full Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
title_fullStr Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
title_full_unstemmed Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
title_sort Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators.
dc.creator.none.fl_str_mv Serna, Eva
Cespedes, Cristina
Vina, Jose
author Serna, Eva
author_facet Serna, Eva
Cespedes, Cristina
Vina, Jose
author_role author
author2 Cespedes, Cristina
Vina, Jose
author2_role author
author
dc.subject.none.fl_str_mv aryl hydrocarbon receptor
aging
physiological function
topic aryl hydrocarbon receptor
aging
physiological function
description The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor's role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor's main physiological functions (mediated by the modulation of gene expression) were cell regeneration, the immune reaction, intestinal homeostasis, and cell proliferation. Furthermore, it was shown that the loss of this receptor led to premature aging. This process may be caused by the dysregulation of hematopoietic stem cells, loss of glucose and lipid homeostasis, increase in inflammation, and deterioration of the brain. We conclude that the aryl hydrocarbon receptor, apart from its well-established role in xenobiotic detoxication, plays an important role in physiological functions and in the aging process. Modulation of the signaling pathway of this receptor could be a therapeutic target of interest in aging.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15398
url https://incliva.portalinvestigacion.com/publicaciones/15398
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 16616596
ISSNe: 14220067
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
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