Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes

A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their abilit...

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Bibliographic Details
Authors: Martí Centelles, Rosa, Falomir Ventura, Eva, Carda, Miguel, Nieto Gómez, Carla Isabel, Cornago, Mª del Pilar
Format: article
Publication Date:2016
Country:España
Institution:Universidad Nacional de Educación a Distancia
Repository:e-spacio. Repositorio Institucional de la UNED
Language:English
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/12775
Online Access:https://hdl.handle.net/20.500.14468/12775
Access Level:Open access
Keyword:Cytotoxicity
Curcuminoid pyrazoles
Gene downregulation
Telomerase
Description
Summary:A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.

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