A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation

Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments ba...

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Detalles Bibliográficos
Autores: Nonell, Santi, Agut, Montserrat, Ruiz González, Rubén, Reddi, Elena
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/1001
Acceso en línea:http://hdl.handle.net/20.500.14342/1001
https://doi.org/10.3390/ijms161125999
Access Level:acceso abierto
Palabra clave:Fotosensibilització (Biologia)
Citometria de fluxe
Fotoquimioteràpia
Photodynamic therapy
Antimicrobial photoinactivation
MRSA
P. aeruginosa
Photosensitizer
Porphycenes
Flow cytometry
Singlet oxygen
577
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oai_identifier_str oai:dau.url.edu:20.500.14342/1001
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spelling A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluationNonell, SantiAgut, MontserratRuiz González, RubénReddi, ElenaFotosensibilització (Biologia)Citometria de fluxeFotoquimioteràpiaPhotodynamic therapyAntimicrobial photoinactivationMRSAP. aeruginosaPhotosensitizerPorphycenesFlow cytometrySinglet oxygen577Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of bindingMDPIUniversitat Ramon Llull. IQS20202023202020232015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion15 p.application/pdfhttp://hdl.handle.net/20.500.14342/1001https://doi.org/10.3390/ijms161125999RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésInternational Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-Rinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01info:eu-repo/grantAgreement/MINECO/PN I+D/IT2009-003Attribution 4.0 International© L'autor/ahttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/10012026-06-21T06:40:37Z
dc.title.none.fl_str_mv A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
title A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
spellingShingle A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
Nonell, Santi
Fotosensibilització (Biologia)
Citometria de fluxe
Fotoquimioteràpia
Photodynamic therapy
Antimicrobial photoinactivation
MRSA
P. aeruginosa
Photosensitizer
Porphycenes
Flow cytometry
Singlet oxygen
577
title_short A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
title_full A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
title_fullStr A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
title_full_unstemmed A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
title_sort A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
dc.creator.none.fl_str_mv Nonell, Santi
Agut, Montserrat
Ruiz González, Rubén
Reddi, Elena
author Nonell, Santi
author_facet Nonell, Santi
Agut, Montserrat
Ruiz González, Rubén
Reddi, Elena
author_role author
author2 Agut, Montserrat
Ruiz González, Rubén
Reddi, Elena
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Fotosensibilització (Biologia)
Citometria de fluxe
Fotoquimioteràpia
Photodynamic therapy
Antimicrobial photoinactivation
MRSA
P. aeruginosa
Photosensitizer
Porphycenes
Flow cytometry
Singlet oxygen
577
topic Fotosensibilització (Biologia)
Citometria de fluxe
Fotoquimioteràpia
Photodynamic therapy
Antimicrobial photoinactivation
MRSA
P. aeruginosa
Photosensitizer
Porphycenes
Flow cytometry
Singlet oxygen
577
description Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of binding
publishDate 2015
dc.date.none.fl_str_mv 2015
2020
2020
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/1001
https://doi.org/10.3390/ijms161125999
url http://hdl.handle.net/20.500.14342/1001
https://doi.org/10.3390/ijms161125999
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01
info:eu-repo/grantAgreement/MINECO/PN I+D/IT2009-003
dc.rights.none.fl_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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