Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients
Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysi...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/226636 |
| Acceso en línea: | https://hdl.handle.net/2445/226636 |
| Access Level: | acceso abierto |
| Palabra clave: | Esquizofrènia Localitzacions cerebrals Neuropsicologia Schizophrenia Localization of cerebral functions Neuropsychology |
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Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patientsPujol, NúriaPenadés Rubio, RafaelRametti, GiuseppinaCatalán Campos, RosaVidal Piñeiro, DídacPalacios, Eva M.Bargalló Alabart, NúriaBernardo Arroyo, MiquelJunqué i Plaja, Carme, 1955-EsquizofrèniaLocalitzacions cerebralsNeuropsicologiaSchizophreniaLocalization of cerebral functionsNeuropsychologyAlthough working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysis and surface-based morphometry to 14 patients with schizophrenia and 14 healthy controls. Neurocognitive functioning was assessed by a neuropsychological test battery that measured executive function. It was hypothesized that working memory dysfunctional connectivity in schizophrenia is related to underlying anatomical abnormalities. Patients with schizophrenia showed cortical thinning in the left inferior frontal gyrus and insula, which explained 57% of blood oxygenation level-dependent signal magnitude in functional magnetic resonance imaging in the central executive network (lateral prefrontal and parietal cortex) over-activation and default mode network (anterior and posterior cingulate) deactivation. No structure-function relationship emerged in the healthy control group. The study provides evidence to suggest that dysfunctional activation/deactivation patterns in schizophrenia may be explained in terms of underlying gray matter deficits.Elsevier B.V.2026202620132026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion8 p.application/pdfhttps://hdl.handle.net/2445/226636Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.pscychresns.2013.06.008Psychiatry Research-Neuroimaging, 2013, vol. 214, num.2, p. 94-101https://doi.org/10.1016/j.pscychresns.2013.06.008(c) Elsevier B.V., 2013info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2266362026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| title |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| spellingShingle |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients Pujol, Núria Esquizofrènia Localitzacions cerebrals Neuropsicologia Schizophrenia Localization of cerebral functions Neuropsychology |
| title_short |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| title_full |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| title_fullStr |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| title_full_unstemmed |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| title_sort |
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients |
| dc.creator.none.fl_str_mv |
Pujol, Núria Penadés Rubio, Rafael Rametti, Giuseppina Catalán Campos, Rosa Vidal Piñeiro, Dídac Palacios, Eva M. Bargalló Alabart, Núria Bernardo Arroyo, Miquel Junqué i Plaja, Carme, 1955- |
| author |
Pujol, Núria |
| author_facet |
Pujol, Núria Penadés Rubio, Rafael Rametti, Giuseppina Catalán Campos, Rosa Vidal Piñeiro, Dídac Palacios, Eva M. Bargalló Alabart, Núria Bernardo Arroyo, Miquel Junqué i Plaja, Carme, 1955- |
| author_role |
author |
| author2 |
Penadés Rubio, Rafael Rametti, Giuseppina Catalán Campos, Rosa Vidal Piñeiro, Dídac Palacios, Eva M. Bargalló Alabart, Núria Bernardo Arroyo, Miquel Junqué i Plaja, Carme, 1955- |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Esquizofrènia Localitzacions cerebrals Neuropsicologia Schizophrenia Localization of cerebral functions Neuropsychology |
| topic |
Esquizofrènia Localitzacions cerebrals Neuropsicologia Schizophrenia Localization of cerebral functions Neuropsychology |
| description |
Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysis and surface-based morphometry to 14 patients with schizophrenia and 14 healthy controls. Neurocognitive functioning was assessed by a neuropsychological test battery that measured executive function. It was hypothesized that working memory dysfunctional connectivity in schizophrenia is related to underlying anatomical abnormalities. Patients with schizophrenia showed cortical thinning in the left inferior frontal gyrus and insula, which explained 57% of blood oxygenation level-dependent signal magnitude in functional magnetic resonance imaging in the central executive network (lateral prefrontal and parietal cortex) over-activation and default mode network (anterior and posterior cingulate) deactivation. No structure-function relationship emerged in the healthy control group. The study provides evidence to suggest that dysfunctional activation/deactivation patterns in schizophrenia may be explained in terms of underlying gray matter deficits. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/226636 |
| url |
https://hdl.handle.net/2445/226636 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1016/j.pscychresns.2013.06.008 Psychiatry Research-Neuroimaging, 2013, vol. 214, num.2, p. 94-101 https://doi.org/10.1016/j.pscychresns.2013.06.008 |
| dc.rights.none.fl_str_mv |
(c) Elsevier B.V., 2013 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Elsevier B.V., 2013 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
8 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Psicologia Clínica i Psicobiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15,812429 |