Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate t...

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Detalles Bibliográficos
Autores: Huang, Ruyi, Wei, Yongyue, Hung, Rayjean J., Liu, Geoffrey, Su, Li, Zhang, Ruyang, Zong, Xuchen, Zhang, Zuo-Feng, Morgenstern, Hal, Brüske, Irene, Heinrich, Joachim, Hong, Yun-Chul, Kim, Jin Hee, Coté, Michele L., Wenzlaff, Angela, Schwartz, Ann G., Stucker, Isabelle, McLaughlin, John R., Marcus, Michael W., Davies, Michael P. A., Liloglou, Triantafillos, Field, John K., Matsuo, Keitaro, Barnett, Matt, Thornquist, Mark D., Goodman, Gary E., Wang, Yi, Chen, Size, Yang, Ping, Duell, Eric J., Andrew, Angeline S., Lazarus, Philip, Muscat, Joshua E., Woll, Penella, Horsman, Janet, Teare, M. Dawn, Flugelman, Anath, Rennert, Gad, Zhang, Yan, Brenner, Hermann, Stegmaier, Christa, van der Heijden, Erik H. F. M., Aben, Katja K., Kiemeney, Lambertus A. L. M., Barros Dios, Juan M., Pérez Ríos, Mónica, Ruano-Ravina, Alberto, Caporaso, Neil E., Bertazzi, Pier Alberto, Landi, Maria Teresa, Dai, Juncheng, Shen, Hongbing, Fernandez Tardón, Guillermo, Rodriguez Suarez, Marta, Tardón, Adonina, Christiani, David C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126860
Acceso en línea:https://hdl.handle.net/2445/126860
Access Level:acceso abierto
Palabra clave:Malalties pulmonars obstructives cròniques
Càncer de pulmó
Chronic obstructive pulmonary diseases
Lung cancer
Descripción
Sumario:Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%(quit_for_5-9 years) to 89%(quit_for_>= 20 years) declined SCLC risk vs. subjects who had quit smoking <5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.

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