Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives

The transmetalation reaction between zinc dithiocarbamates functionalized with organic groups and the cation fac-[Tc(HO)(CO)] has been studied as a new strategy to bind biomolecules to this radionuclide for preparing radiopharmaceuticals with high molar activity. All complexes were obtained in high...

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Autores: Borràs, Jordi, Lecina Vicente, Joan, Foster, Julie|||0000-0002-6492-2106, Kashani, Roxana, Melendez-Alafort, L..|||0000-0003-0701-3616, Sosabowski, Jane|||0000-0001-7653-5923, Suades Ortuño, Joan|||0000-0002-6743-7536
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:250643
Acceso en línea:https://ddd.uab.cat/record/250643
https://dx.doi.org/urn:doi:10.1016/j.bmcl.2021.127840
Access Level:acceso abierto
Palabra clave:Technetium
Carbonyl
Radiopharmaceutical
Transmetallation
Rhenium
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spelling Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivativesBorràs, JordiLecina Vicente, JoanFoster, Julie|||0000-0002-6492-2106Kashani, RoxanaMelendez-Alafort, L..|||0000-0003-0701-3616Sosabowski, Jane|||0000-0001-7653-5923Suades Ortuño, Joan|||0000-0002-6743-7536TechnetiumCarbonylRadiopharmaceuticalTransmetallationRheniumThe transmetalation reaction between zinc dithiocarbamates functionalized with organic groups and the cation fac-[Tc(HO)(CO)] has been studied as a new strategy to bind biomolecules to this radionuclide for preparing radiopharmaceuticals with high molar activity. All complexes were obtained in high yields by heating at moderate temperatures and without subsequent purification. The chemical identity was ascertained by HPLC comparison with the homologous rhenium complexes. Stability studies in cysteine solution and serum have shown a good stability of the coordination set fac-[Tc(CO)(SS)(P)]. Preliminary biological studies of the radiocomplex functionalized with D-(+)-glucosamine with carcinoma cells have been performed. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/250643https://dx.doi.org/urn:doi:10.1016/j.bmcl.2021.127840reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-67358-C2-2-PMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CTQ2015-70371-REDTAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-795open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2506432026-06-06T12:50:31Z
dc.title.none.fl_str_mv Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
title Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
spellingShingle Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
Borràs, Jordi
Technetium
Carbonyl
Radiopharmaceutical
Transmetallation
Rhenium
title_short Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
title_full Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
title_fullStr Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
title_full_unstemmed Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
title_sort Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
dc.creator.none.fl_str_mv Borràs, Jordi
Lecina Vicente, Joan
Foster, Julie|||0000-0002-6492-2106
Kashani, Roxana
Melendez-Alafort, L..|||0000-0003-0701-3616
Sosabowski, Jane|||0000-0001-7653-5923
Suades Ortuño, Joan|||0000-0002-6743-7536
author Borràs, Jordi
author_facet Borràs, Jordi
Lecina Vicente, Joan
Foster, Julie|||0000-0002-6492-2106
Kashani, Roxana
Melendez-Alafort, L..|||0000-0003-0701-3616
Sosabowski, Jane|||0000-0001-7653-5923
Suades Ortuño, Joan|||0000-0002-6743-7536
author_role author
author2 Lecina Vicente, Joan
Foster, Julie|||0000-0002-6492-2106
Kashani, Roxana
Melendez-Alafort, L..|||0000-0003-0701-3616
Sosabowski, Jane|||0000-0001-7653-5923
Suades Ortuño, Joan|||0000-0002-6743-7536
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Technetium
Carbonyl
Radiopharmaceutical
Transmetallation
Rhenium
topic Technetium
Carbonyl
Radiopharmaceutical
Transmetallation
Rhenium
description The transmetalation reaction between zinc dithiocarbamates functionalized with organic groups and the cation fac-[Tc(HO)(CO)] has been studied as a new strategy to bind biomolecules to this radionuclide for preparing radiopharmaceuticals with high molar activity. All complexes were obtained in high yields by heating at moderate temperatures and without subsequent purification. The chemical identity was ascertained by HPLC comparison with the homologous rhenium complexes. Stability studies in cysteine solution and serum have shown a good stability of the coordination set fac-[Tc(CO)(SS)(P)]. Preliminary biological studies of the radiocomplex functionalized with D-(+)-glucosamine with carcinoma cells have been performed.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/250643
https://dx.doi.org/urn:doi:10.1016/j.bmcl.2021.127840
url https://ddd.uab.cat/record/250643
https://dx.doi.org/urn:doi:10.1016/j.bmcl.2021.127840
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-67358-C2-2-P
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CTQ2015-70371-REDT
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-795
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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