Platelet Transfusion: and Update on Challenges and Outcomes

Platelet transfusion is a common practice in onco-hematologic patients for preventing or treating hemorrhages. Platelet concentrates can be transfused with therapeutic or prophylactic purposes. With the aim to help clinicians to take the decisions on platelet transfusion, some guidelines have been d...

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Detalles Bibliográficos
Autor: Solves Alcaina, Pilar
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19749
Acceso en línea:https://hdl.handle.net/20.500.13003/19749
Access Level:acceso abierto
Palabra clave:platelet transfusion
prophylactic transfusion
platelet transfusion refractoriness
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spelling Platelet Transfusion: and Update on Challenges and OutcomesSolves Alcaina, Pilarplatelet transfusionprophylactic transfusionplatelet transfusion refractorinessPlatelet transfusion is a common practice in onco-hematologic patients for preventing or treating hemorrhages. Platelet concentrates can be transfused with therapeutic or prophylactic purposes. With the aim to help clinicians to take the decisions on platelet transfusion, some guidelines have been developed based on the current scientific evidence. However, there are some controversial issues and available scientific evidence is not enough to solve them. There is little information about what is the best platelet product to be transfused: random platelets or single donor apheresis platelets, and plasma-suspended or additive solution suspended platelets. Platelets are often transfused without respecting the ABO compatibility, but influence of this practice on platelet transfusion outcome is not well established. In the prophylactic platelet transfusion set there are some questions unsolved as the platelet threshold to transfuse prior to specific procedures or surgery, and even if platelet transfusion is necessary for some specific procedures as autologous hematopoietic stem cell transplantation. A challenging complication raised from multiple platelet transfusions is the platelet transfusion refractoriness. The study and management of this complication is often disappointing. In summary, although it is a widespread practice, platelet transfusion has still many controversial and unknown issues. The objective of this research article is to review the current evidence on platelet transfusion practices, focusing on the controversial issues and challenges.Dove Medical Press Ltd20202020-01-0120202020-01-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19749reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/197492026-06-22T12:44:07Z
dc.title.none.fl_str_mv Platelet Transfusion: and Update on Challenges and Outcomes
title Platelet Transfusion: and Update on Challenges and Outcomes
spellingShingle Platelet Transfusion: and Update on Challenges and Outcomes
Solves Alcaina, Pilar
platelet transfusion
prophylactic transfusion
platelet transfusion refractoriness
title_short Platelet Transfusion: and Update on Challenges and Outcomes
title_full Platelet Transfusion: and Update on Challenges and Outcomes
title_fullStr Platelet Transfusion: and Update on Challenges and Outcomes
title_full_unstemmed Platelet Transfusion: and Update on Challenges and Outcomes
title_sort Platelet Transfusion: and Update on Challenges and Outcomes
dc.creator.none.fl_str_mv Solves Alcaina, Pilar
author Solves Alcaina, Pilar
author_facet Solves Alcaina, Pilar
author_role author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv platelet transfusion
prophylactic transfusion
platelet transfusion refractoriness
topic platelet transfusion
prophylactic transfusion
platelet transfusion refractoriness
description Platelet transfusion is a common practice in onco-hematologic patients for preventing or treating hemorrhages. Platelet concentrates can be transfused with therapeutic or prophylactic purposes. With the aim to help clinicians to take the decisions on platelet transfusion, some guidelines have been developed based on the current scientific evidence. However, there are some controversial issues and available scientific evidence is not enough to solve them. There is little information about what is the best platelet product to be transfused: random platelets or single donor apheresis platelets, and plasma-suspended or additive solution suspended platelets. Platelets are often transfused without respecting the ABO compatibility, but influence of this practice on platelet transfusion outcome is not well established. In the prophylactic platelet transfusion set there are some questions unsolved as the platelet threshold to transfuse prior to specific procedures or surgery, and even if platelet transfusion is necessary for some specific procedures as autologous hematopoietic stem cell transplantation. A challenging complication raised from multiple platelet transfusions is the platelet transfusion refractoriness. The study and management of this complication is often disappointing. In summary, although it is a widespread practice, platelet transfusion has still many controversial and unknown issues. The objective of this research article is to review the current evidence on platelet transfusion practices, focusing on the controversial issues and challenges.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19749
url https://hdl.handle.net/20.500.13003/19749
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press Ltd
publisher.none.fl_str_mv Dove Medical Press Ltd
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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