Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of...

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Detalles Bibliográficos
Autores: Fagundo, Ana B., Jiménez-Murcia, Susana, Giner Bartolomé, C., Agüera, Zaida, Sauchelli, Sarah, Pardo, M., Crujeiras, Ana B., Granero, Roser, Baños, Rosa M., Botella, Cristina, Torre, Rafael de la, Fernández-Real Lemos, José Manuel, Fernández García, Jose C., Frühbeck, Gema, Rodríguez, Amaia, Mallorquí Bagué, Núria, Tárrega, Salomé, Tinahones, Francisco J., Rodríguez, Rocío, Ortega Delgado, Francisco José, Menchón Magriñá, José Manuel, Casanueva, Felipe F., Fernández Aranda, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/14031
Acceso en línea:http://hdl.handle.net/10256/14031
Access Level:acceso abierto
Palabra clave:Obesitat -- Tractament
Obesity -- Treatment
Obesitat mòrbida -- Tractament
Morbid obesity -- Treatment
Descripción
Sumario:Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use

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