Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study

This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between J...

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Detalles Bibliográficos
Autores: Vilchez Rueda, Helem Haydee, Escudero-Sanchez, Rosa, Fernandez-Sampedro, Marta, Murillo, Oscar, Aunon, Alvaro, Rodriguez-Pardo, Dolors, Jover-Saenz, Alfredo, del Toro, Maria Dolores, Rico, Alicia, Falgueras, Luis, Praena-Segovia, Julia, Guio, Laura, Iribarren, Jose A., Lora-Tamayo, Jaime, Benito, Natividad, Morata, Laura, Ramirez, Antonio, Riera, Melchor, Study Grp Osteoarticular Infection; Spanish Network Res Infect Patholo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19779
Acceso en línea:https://hdl.handle.net/20.500.13003/19779
Access Level:acceso abierto
Palabra clave:Cutibacterium acnes
prosthetic joint infection
surgical and medical treatment
Descripción
Sumario:This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included beta-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with beta-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.

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