The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.

Objective. To determine if patients with the predominant extracranial large-vessel vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-...

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Autores: Prieto-Peña, Diana, Remuzgo-Martínez, Sara, Ocejo-Vinyals, J. Gonzalo, Atienza-Mateo, Belén, Genre, Fernanda, Muñoz Jiménez, Alejandro, Ortiz-Sanjuán, Francisco, Romero-Yuste, Susana, Moriano, Clara, Galíndez-Agirregoikoa, Eva, Calvo, Itziar, Ortego-Centeno, Norberto, Álvarez-Rivas, Noelia, Miranda-Filloy, José Antonio, Llorente, Irene, García-García, Javier, Blanco, Ricardo, Gualillo, Oreste, Martin, Javier, Castañeda, Santos, López-Mejías, Raquel, González-Gay, Miguel A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/359722
Acceso en línea:http://hdl.handle.net/10261/359722
Access Level:acceso abierto
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spelling The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.Prieto-Peña, DianaRemuzgo-Martínez, SaraOcejo-Vinyals, J. GonzaloAtienza-Mateo, BelénGenre, FernandaMuñoz Jiménez, AlejandroOrtiz-Sanjuán, FranciscoRomero-Yuste, SusanaMoriano, ClaraGalíndez-Agirregoikoa, EvaCalvo, ItziarOrtego-Centeno, NorbertoÁlvarez-Rivas, NoeliaMiranda-Filloy, José AntonioLlorente, IreneGarcía-García, JavierBlanco, RicardoGualillo, OresteMartin, JavierCastañeda, SantosLópez-Mejías, RaquelGonzález-Gay, Miguel A.Objective. To determine if patients with the predominant extracranial large-vessel vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLADRB1 alleles confers an increased risk for GCA susceptibility, both for the cranial and extracranial LVV phenotypes. Methods. A total of 184 patients with biopsy-proven cranial GCA, 105 with LVV-GCA and 486 healthy controls were included in our study. We compared HLA-B phenotype frequencies between the three groups. Results. HLA-B*15 phenotype was significantly increased in patients with classic cranial GCA compared to controls (14.7% vs. 5.8%, respectively; p<0.01; OR [95% CI]=2.81 [1.54-5.11]). It was mainly due to the HLA-B*15:01 allele (12.5% vs. 4.0%, respectively; p<0.01; OR [95% CI]=3.51 [1.77-6.99]) and remained statistically significant after Bonferroni correction. Similar HLA-B*15 association was observed in patients with the LVV-GCA (11.4% vs. 5.8%, p=0.04, OR [95% CI]=2.11 [1.04-4.30]). This association was also mainly due to the HLA-B*15:01 allele (10.5% vs. 4.0%, respectively; p=0.0054; OR [95% CI]=2.88 [1.19-6.59]). Noteworthy, the presence of HLA-B*15:01 together with HLA-DRB1*04:01 led to an increased risk of developing both cranial and extracranial LVV-GCA. Conclusion. Susceptibility to GCA is strongly related to the HLA region, regardless of the clinical phenotype of expression of the disease.Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420212024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/359722reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3597222026-05-22T06:33:51Z
dc.title.none.fl_str_mv The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
title The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
spellingShingle The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
Prieto-Peña, Diana
title_short The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
title_full The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
title_fullStr The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
title_full_unstemmed The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
title_sort The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
dc.creator.none.fl_str_mv Prieto-Peña, Diana
Remuzgo-Martínez, Sara
Ocejo-Vinyals, J. Gonzalo
Atienza-Mateo, Belén
Genre, Fernanda
Muñoz Jiménez, Alejandro
Ortiz-Sanjuán, Francisco
Romero-Yuste, Susana
Moriano, Clara
Galíndez-Agirregoikoa, Eva
Calvo, Itziar
Ortego-Centeno, Norberto
Álvarez-Rivas, Noelia
Miranda-Filloy, José Antonio
Llorente, Irene
García-García, Javier
Blanco, Ricardo
Gualillo, Oreste
Martin, Javier
Castañeda, Santos
López-Mejías, Raquel
González-Gay, Miguel A.
author Prieto-Peña, Diana
author_facet Prieto-Peña, Diana
Remuzgo-Martínez, Sara
Ocejo-Vinyals, J. Gonzalo
Atienza-Mateo, Belén
Genre, Fernanda
Muñoz Jiménez, Alejandro
Ortiz-Sanjuán, Francisco
Romero-Yuste, Susana
Moriano, Clara
Galíndez-Agirregoikoa, Eva
Calvo, Itziar
Ortego-Centeno, Norberto
Álvarez-Rivas, Noelia
Miranda-Filloy, José Antonio
Llorente, Irene
García-García, Javier
Blanco, Ricardo
Gualillo, Oreste
Martin, Javier
Castañeda, Santos
López-Mejías, Raquel
González-Gay, Miguel A.
author_role author
author2 Remuzgo-Martínez, Sara
Ocejo-Vinyals, J. Gonzalo
Atienza-Mateo, Belén
Genre, Fernanda
Muñoz Jiménez, Alejandro
Ortiz-Sanjuán, Francisco
Romero-Yuste, Susana
Moriano, Clara
Galíndez-Agirregoikoa, Eva
Calvo, Itziar
Ortego-Centeno, Norberto
Álvarez-Rivas, Noelia
Miranda-Filloy, José Antonio
Llorente, Irene
García-García, Javier
Blanco, Ricardo
Gualillo, Oreste
Martin, Javier
Castañeda, Santos
López-Mejías, Raquel
González-Gay, Miguel A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Objective. To determine if patients with the predominant extracranial large-vessel vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLADRB1 alleles confers an increased risk for GCA susceptibility, both for the cranial and extracranial LVV phenotypes. Methods. A total of 184 patients with biopsy-proven cranial GCA, 105 with LVV-GCA and 486 healthy controls were included in our study. We compared HLA-B phenotype frequencies between the three groups. Results. HLA-B*15 phenotype was significantly increased in patients with classic cranial GCA compared to controls (14.7% vs. 5.8%, respectively; p<0.01; OR [95% CI]=2.81 [1.54-5.11]). It was mainly due to the HLA-B*15:01 allele (12.5% vs. 4.0%, respectively; p<0.01; OR [95% CI]=3.51 [1.77-6.99]) and remained statistically significant after Bonferroni correction. Similar HLA-B*15 association was observed in patients with the LVV-GCA (11.4% vs. 5.8%, p=0.04, OR [95% CI]=2.11 [1.04-4.30]). This association was also mainly due to the HLA-B*15:01 allele (10.5% vs. 4.0%, respectively; p=0.0054; OR [95% CI]=2.88 [1.19-6.59]). Noteworthy, the presence of HLA-B*15:01 together with HLA-DRB1*04:01 led to an increased risk of developing both cranial and extracranial LVV-GCA. Conclusion. Susceptibility to GCA is strongly related to the HLA region, regardless of the clinical phenotype of expression of the disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/359722
url http://hdl.handle.net/10261/359722
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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