Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.

Ng, Ted K S; Udeh-Momoh, Chinedu; Lim, Mei-Ann; Gleerup, Helena Sophia; Leifert, Wayne; Ajalo, Catherine; Ashton, Nicholas; Zetterberg, Henrik; Rissman, Robert A; Winston, Charisse N; O' Bryant, Sid; Jenkins, Robert; Carro, Eva; Orive, Gorka; Tamburin, Stefano; Olvera-Rojas, Marcos; Solis-Urra, Patricio; Esteban-Cornejo, Irene; Santos, Gustavo Alves Andrade Dos; Rajan, Kumar B; Koh, David; Simonsen, Anja Hviid; Slowey, Paul D; Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)

Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.

There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could co...

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Autores:	Ng, Ted K S, Udeh-Momoh, Chinedu, Lim, Mei-Ann, Gleerup, Helena Sophia, Leifert, Wayne, Ajalo, Catherine, Ashton, Nicholas, Zetterberg, Henrik, Rissman, Robert A, Winston, Charisse N, O' Bryant, Sid, Jenkins, Robert, Carro, Eva, Orive, Gorka, Tamburin, Stefano, Olvera-Rojas, Marcos, Solis-Urra, Patricio, Esteban-Cornejo, Irene, Santos, Gustavo Alves Andrade Dos, Rajan, Kumar B, Koh, David, Simonsen, Anja Hviid, Slowey, Paul D, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/26338
Acceso en línea:	https://hdl.handle.net/20.500.12105/26338
Access Level:	acceso abierto
Palabra clave:	Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling

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spelling	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.Ng, Ted K SUdeh-Momoh, ChineduLim, Mei-AnnGleerup, Helena SophiaLeifert, WayneAjalo, CatherineAshton, NicholasZetterberg, HenrikRissman, Robert AWinston, Charisse NO' Bryant, SidJenkins, RobertCarro, EvaOrive, GorkaTamburin, StefanoOlvera-Rojas, MarcosSolis-Urra, PatricioEsteban-Cornejo, IreneSantos, Gustavo Alves Andrade DosRajan, Kumar BKoh, DavidSimonsen, Anja HviidSlowey, Paul DAlzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)Alzheimer's diseaseBiomarkersMeasurement protocolNon‐invasivePre‐analytical variablesSalivaSamplingThere is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables could influence the detection and quantification of salivary biomarkers, showed technologies available to standardize collection procedures, and proposed a standardized pre-analytical protocol to guide future studies on salivary AD biomarker examinations. We identified potential contexts of use, gaps, and priorities and proposed future research directions. HIGHLIGHTS: Given its non-invasive nature, wider accessibility, and cultural acceptability, particularly in low-resourced settings, saliva is a biofluid complementary to blood and CSF. Current salivary AD biomarker studies do not control for many confounding pre-analytical variables during the sampling process, potentially leading to inaccurate salivary biomarker readings and conclusions, contributing to conflicting findings. Reviewing the current literature, including the consistencies and non-consistencies observed in the existing parameters and methodologies, discussing how they can affect salivary AD biomarker detection and quantification. Proposing a standardized salivary pre-analytical protocol, identifying the gaps and prioritizations needed to move this area forward, proposing future directions and potential contexts of use.Wiley20252025-02-1720242024-12-3020242024-12-30review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/26338reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/263382026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
title	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
spellingShingle	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. Ng, Ted K S Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling
title_short	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
title_full	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
title_fullStr	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
title_full_unstemmed	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
title_sort	Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
dc.creator.none.fl_str_mv	Ng, Ted K S Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
author	Ng, Ted K S
author_facet	Ng, Ted K S Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
author_role	author
author2	Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling
topic	Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling
description	There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables could influence the detection and quantification of salivary biomarkers, showed technologies available to standardize collection procedures, and proposed a standardized pre-analytical protocol to guide future studies on salivary AD biomarker examinations. We identified potential contexts of use, gaps, and priorities and proposed future research directions. HIGHLIGHTS: Given its non-invasive nature, wider accessibility, and cultural acceptability, particularly in low-resourced settings, saliva is a biofluid complementary to blood and CSF. Current salivary AD biomarker studies do not control for many confounding pre-analytical variables during the sampling process, potentially leading to inaccurate salivary biomarker readings and conclusions, contributing to conflicting findings. Reviewing the current literature, including the consistencies and non-consistencies observed in the existing parameters and methodologies, discussing how they can affect salivary AD biomarker detection and quantification. Proposing a standardized salivary pre-analytical protocol, identifying the gaps and prioritizations needed to move this area forward, proposing future directions and potential contexts of use.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-12-30 2024 2024-12-30 2025 2025-02-17
dc.type.none.fl_str_mv	review article http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.12105/26338
url	https://hdl.handle.net/20.500.12105/26338
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
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Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.

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