Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU
(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/188631 |
| Acceso en línea: | https://hdl.handle.net/2445/188631 |
| Access Level: | acceso abierto |
| Palabra clave: | Malalties inflamatòries intestinals Tuberculosi Inflammatory bowel diseases Tuberculosis |
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oai:diposit.ub.edu:2445/188631 |
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Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCURiestra, SabinoTaxonera, CarlosZabana Abdo, YamileCarpio, DanielChaparro, MaríaBarrio, JesúsRivero, MontserratLópez Sanroman, AntonioEsteve, MariaFrancisco, Ruth deBastida, GuillermoGarcía López, SantiagoMañosa, MíriamMartin Arranz, María DoloresPérez Calle, José LázaroGuardiola, JordiMuñoz, FernandoArranz, LauraCabriada, José LuisGarcía Sepulcre, Mariana FeNavarro, MercèMontoro Huguet, Miguel ÁngelRicart, ElenaBermejo, FernandoCalvet, XavierPiqueras, MartaGarcia Planella, EstherMárquez, LucíaMínguez, MiguelVan Domselar, ManuelBujanda, LuisAldeguer, XavierSicilia, BeatrizIglesias, EvaAlcaín, GuillermoPérez Martínez, IsabelRolle, ValeriaCastaño García, AndrésGisbert, Javier P.Domènech, EugeniThe ENEIDA Registry From GETECCUMalalties inflamatòries intestinalsTuberculosiInflammatory bowel diseasesTuberculosis(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-gamma-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18-20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50-0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66-0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20-22%] vs. 14% [95% CI 13-16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.MDPI AG2022info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/188631Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm11133915Journal of Clinical Medicine, 2022, vol. 11, num. 13, p. 3915https://doi.org/10.3390/jcm11133915cc by (c) Riestra, Sabino et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1886312026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| title |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| spellingShingle |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU Riestra, Sabino Malalties inflamatòries intestinals Tuberculosi Inflammatory bowel diseases Tuberculosis |
| title_short |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| title_full |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| title_fullStr |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| title_full_unstemmed |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| title_sort |
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU |
| dc.creator.none.fl_str_mv |
Riestra, Sabino Taxonera, Carlos Zabana Abdo, Yamile Carpio, Daniel Chaparro, María Barrio, Jesús Rivero, Montserrat López Sanroman, Antonio Esteve, Maria Francisco, Ruth de Bastida, Guillermo García López, Santiago Mañosa, Míriam Martin Arranz, María Dolores Pérez Calle, José Lázaro Guardiola, Jordi Muñoz, Fernando Arranz, Laura Cabriada, José Luis García Sepulcre, Mariana Fe Navarro, Mercè Montoro Huguet, Miguel Ángel Ricart, Elena Bermejo, Fernando Calvet, Xavier Piqueras, Marta Garcia Planella, Esther Márquez, Lucía Mínguez, Miguel Van Domselar, Manuel Bujanda, Luis Aldeguer, Xavier Sicilia, Beatriz Iglesias, Eva Alcaín, Guillermo Pérez Martínez, Isabel Rolle, Valeria Castaño García, Andrés Gisbert, Javier P. Domènech, Eugeni The ENEIDA Registry From GETECCU |
| author |
Riestra, Sabino |
| author_facet |
Riestra, Sabino Taxonera, Carlos Zabana Abdo, Yamile Carpio, Daniel Chaparro, María Barrio, Jesús Rivero, Montserrat López Sanroman, Antonio Esteve, Maria Francisco, Ruth de Bastida, Guillermo García López, Santiago Mañosa, Míriam Martin Arranz, María Dolores Pérez Calle, José Lázaro Guardiola, Jordi Muñoz, Fernando Arranz, Laura Cabriada, José Luis García Sepulcre, Mariana Fe Navarro, Mercè Montoro Huguet, Miguel Ángel Ricart, Elena Bermejo, Fernando Calvet, Xavier Piqueras, Marta Garcia Planella, Esther Márquez, Lucía Mínguez, Miguel Van Domselar, Manuel Bujanda, Luis Aldeguer, Xavier Sicilia, Beatriz Iglesias, Eva Alcaín, Guillermo Pérez Martínez, Isabel Rolle, Valeria Castaño García, Andrés Gisbert, Javier P. Domènech, Eugeni The ENEIDA Registry From GETECCU |
| author_role |
author |
| author2 |
Taxonera, Carlos Zabana Abdo, Yamile Carpio, Daniel Chaparro, María Barrio, Jesús Rivero, Montserrat López Sanroman, Antonio Esteve, Maria Francisco, Ruth de Bastida, Guillermo García López, Santiago Mañosa, Míriam Martin Arranz, María Dolores Pérez Calle, José Lázaro Guardiola, Jordi Muñoz, Fernando Arranz, Laura Cabriada, José Luis García Sepulcre, Mariana Fe Navarro, Mercè Montoro Huguet, Miguel Ángel Ricart, Elena Bermejo, Fernando Calvet, Xavier Piqueras, Marta Garcia Planella, Esther Márquez, Lucía Mínguez, Miguel Van Domselar, Manuel Bujanda, Luis Aldeguer, Xavier Sicilia, Beatriz Iglesias, Eva Alcaín, Guillermo Pérez Martínez, Isabel Rolle, Valeria Castaño García, Andrés Gisbert, Javier P. Domènech, Eugeni The ENEIDA Registry From GETECCU |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malalties inflamatòries intestinals Tuberculosi Inflammatory bowel diseases Tuberculosis |
| topic |
Malalties inflamatòries intestinals Tuberculosi Inflammatory bowel diseases Tuberculosis |
| description |
(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-gamma-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18-20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50-0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66-0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20-22%] vs. 14% [95% CI 13-16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/188631 |
| url |
https://hdl.handle.net/2445/188631 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3390/jcm11133915 Journal of Clinical Medicine, 2022, vol. 11, num. 13, p. 3915 https://doi.org/10.3390/jcm11133915 |
| dc.rights.none.fl_str_mv |
cc by (c) Riestra, Sabino et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by (c) Riestra, Sabino et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
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MDPI AG |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869419068275032064 |
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15.301603 |