Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?

Background and aim: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. Methods and results: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major...

Descripción completa

Detalles Bibliográficos
Autores: Eguaras, Sonia, Toledo, Estefanía, Buil-Cosiales, P, Salas-Salvado, J, Corella, Dolores, Gutierrez-Bedmar, M, Santos-Lozano, J. M, Aros, F, Fiol Sala, Miquel, Fito Manteca, Maria Concepcion, Ros, E, Serra-Majem, L, Pinto, X, Martinez, JA, Sorli, JV, Munoz, MA, Basora, J, Estruch, Ramon, Martinez-Gonzalez, MA, PREDIMED Investigators
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20176
Acceso en línea:http://hdl.handle.net/20.500.12105/20176
Access Level:acceso abierto
Palabra clave:Índice de Masa Corporal
Dieta Mediterránea
Incidencia
Modelos de Riesgos Proporcionales
Resultado del Tratamiento
Factores de Tiempo
Femenino
Análisis Multivariante
Masculino
Factores Protectores
Circunferencia de la Cintura
Obesidad Abdominal
Factores de Riesgo
Humanos
Persona de Mediana Edad
Anciano
Anciano de 80 o más Años
Prevención Primaria
Enfermedades Cardiovasculares
España
Adiposidad
Cardiovascular Diseases
Descripción
Sumario:Background and aim: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. Methods and results: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043). Conclusions: The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD.

Similares en LA Referencia