Real-world evidence of Carfilzomib, Lenalidomide and Dexamethasone (KRD) Scheme in patients with relapsed / refractory multiple myeloma

Carfilzomib, lenalidomide and dexamethasone (KRd) is still a widely used treatment option for patients with relapsed / refractory multiple myeloma (RRMM). However, there is limited real-world evidence. Here we evaluated the efficacy and safety of KRd in patients with RRMM treated following the stand...

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Detalles Bibliográficos
Autores: Garcia-Guiñón, Antoni, Charry, Paola Andrea, Jimenez, María, Sarra, Josep, Delgado, Izarbe, Segura de la Torre, Laura, Santaliestra, Marta, Garcia-Pintos, Marta, Gonzalez, Yolanda, Senin, Alicia, Motlló, Cristina, Abella, Eugènia, Cabezudo, Elena, Granell, Miquel, Sancho, Esther, Herranz, María José, Seres, Yasmina, Gironella, Mercedes, Soler, Juan Alfons, Marti-Tutusaus, Josep Maria, Ben Azaiz, Ran, Fernandez de Larrea, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/468823
Acceso en línea:https://doi.org/10.1007/s00277-025-06240-1
https://hdl.handle.net/10459.1/468823
Access Level:acceso abierto
Palabra clave:Carfilzomib, lenalidomide and dexamethasone
Real-world
Relapsed/refractory multiple myeloma
Descripción
Sumario:Carfilzomib, lenalidomide and dexamethasone (KRd) is still a widely used treatment option for patients with relapsed / refractory multiple myeloma (RRMM). However, there is limited real-world evidence. Here we evaluated the efficacy and safety of KRd in patients with RRMM treated following the standard clinical practice of the hospitals in the Catalan region. This was a retrospective, observational study. The objective response rate (ORR) according to IMWG criteria was the primary endpoint. Secondary endpoints included progression-free survival (PFS) and overall survival (OS). The study planned to include at least 100-150 patients. In total 194 patients were included. Median age was 64 years (range: 40-88) and 56% were male. All patients had received bortezomib. Additionally, 89 patients (46%) had received thalidomide and 29 (15%) lenalidomide. The ORR was 73% (95% CI: 66-79), with 72 patients (37%) having ≥ CR. The ORR was influenced by ISS score, number of previous treatments and exposure to lenalidomide. The median PFS was 26 months and 2-years OS rate 70%. The ISS stage and LDH levels were independent prognostic factors of survival. In conclusion, the KRd scheme led to a good effectiveness comparable safety profile to the phase III clinical trial in patients with RRMM.

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