Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies

Moringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolate...

Descripción completa

Detalles Bibliográficos
Autores: Nova, Esther, Redondo Useros, Noemí, Martínez García, Rosa María, Gómez Martínez, Sonia, Díaz Prieto, Ligia E., Marcos, Ascensión
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/31221
Acceso en línea:http://hdl.handle.net/10578/31221
Access Level:acceso abierto
Palabra clave:Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
Animal studies
Human studies
id ES_c654c8d1af8fe6eedaf2b56fbab40f36
oai_identifier_str oai:ruidera.uclm.es:10578/31221
network_acronym_str ES
network_name_str España
repository_id_str
spelling Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human StudiesNova, EstherRedondo Useros, NoemíMartínez García, Rosa MaríaGómez Martínez, SoniaDíaz Prieto, Ligia E.Marcos, AscensiónMoringa oleiferaDiabetes mellitusFasting glucoseGlucose toleranceAntioxidant enzymesLipid metabolismAnimal studiesHuman studiesMoringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolates, MO has been shown to exert numerous in vitro activities and in vivo effects, including hypoglycemic activity. A systematic search was carried out in the PubMed database and reference lists on the effects of MO on glucose metabolism. Thirty-three animal studies and eight human studies were included. Water and organic solvent extracts of leaves and, secondly, seeds, have been extensively assayed in animal models, showing the hypoglycemic effect, both under acute conditions and in long-term administrations and also prevention of other metabolic changes and complications associated to the hyperglycemic status. In humans, clinical trials are scarce, with variable designs and testing mainly dry leaf powder alone or mixed with other foods or MO aqueous preparations. Although the reported results are encouraging, especially those from postprandial studies, more human studies are certainly needed with more stringent inclusion criteria and a sufficient number of diabetic or prediabetic subjects. Moreover, trying to quantify the bioactive substances administered with the experimental material tested would facilitate comparison between studies.MDPI202320232020info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10578/31221reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/312212026-05-27T07:36:41Z
dc.title.none.fl_str_mv Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
title Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
spellingShingle Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
Nova, Esther
Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
Animal studies
Human studies
title_short Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
title_full Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
title_fullStr Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
title_full_unstemmed Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
title_sort Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies
dc.creator.none.fl_str_mv Nova, Esther
Redondo Useros, Noemí
Martínez García, Rosa María
Gómez Martínez, Sonia
Díaz Prieto, Ligia E.
Marcos, Ascensión
author Nova, Esther
author_facet Nova, Esther
Redondo Useros, Noemí
Martínez García, Rosa María
Gómez Martínez, Sonia
Díaz Prieto, Ligia E.
Marcos, Ascensión
author_role author
author2 Redondo Useros, Noemí
Martínez García, Rosa María
Gómez Martínez, Sonia
Díaz Prieto, Ligia E.
Marcos, Ascensión
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
Animal studies
Human studies
topic Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
Animal studies
Human studies
description Moringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolates, MO has been shown to exert numerous in vitro activities and in vivo effects, including hypoglycemic activity. A systematic search was carried out in the PubMed database and reference lists on the effects of MO on glucose metabolism. Thirty-three animal studies and eight human studies were included. Water and organic solvent extracts of leaves and, secondly, seeds, have been extensively assayed in animal models, showing the hypoglycemic effect, both under acute conditions and in long-term administrations and also prevention of other metabolic changes and complications associated to the hyperglycemic status. In humans, clinical trials are scarce, with variable designs and testing mainly dry leaf powder alone or mixed with other foods or MO aqueous preparations. Although the reported results are encouraging, especially those from postprandial studies, more human studies are certainly needed with more stringent inclusion criteria and a sufficient number of diabetic or prediabetic subjects. Moreover, trying to quantify the bioactive substances administered with the experimental material tested would facilitate comparison between studies.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10578/31221
url http://hdl.handle.net/10578/31221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419064430952448
score 15,301603

Similares en LA Referencia