HERC ubiquitin ligases in cancer

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell p...

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Autores: Sala Gastón, Joan, Martinez-Martinez, Arturo, Pedrazza, Leonardo, Lorenzo Martín, L. Francisco, Caloto, Rubén, Bustelo, Xosé R., Ventura Pujol, Francesc, Rosa López, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/168599
Acceso en línea:https://hdl.handle.net/2445/168599
Access Level:acceso abierto
Palabra clave:Genomes
Oncogens
Proteïnes supressores de tumors
Oncogenes
Tumor suppressor protein
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spelling HERC ubiquitin ligases in cancerSala Gastón, JoanMartinez-Martinez, ArturoPedrazza, LeonardoLorenzo Martín, L. FranciscoCaloto, RubénBustelo, Xosé R.Ventura Pujol, FrancescRosa López, José LuisGenomesOncogensProteïnes supressores de tumorsGenomesOncogenesTumor suppressor proteinHERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/168599Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cancers12061653Cancers, 2020, vol. 12, num. 6, p. E1653https://doi.org/10.3390/cancers12061653cc-by (c) Sala Gaston, Joan et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1685992026-05-27T06:46:51Z
dc.title.none.fl_str_mv HERC ubiquitin ligases in cancer
title HERC ubiquitin ligases in cancer
spellingShingle HERC ubiquitin ligases in cancer
Sala Gastón, Joan
Genomes
Oncogens
Proteïnes supressores de tumors
Genomes
Oncogenes
Tumor suppressor protein
title_short HERC ubiquitin ligases in cancer
title_full HERC ubiquitin ligases in cancer
title_fullStr HERC ubiquitin ligases in cancer
title_full_unstemmed HERC ubiquitin ligases in cancer
title_sort HERC ubiquitin ligases in cancer
dc.creator.none.fl_str_mv Sala Gastón, Joan
Martinez-Martinez, Arturo
Pedrazza, Leonardo
Lorenzo Martín, L. Francisco
Caloto, Rubén
Bustelo, Xosé R.
Ventura Pujol, Francesc
Rosa López, José Luis
author Sala Gastón, Joan
author_facet Sala Gastón, Joan
Martinez-Martinez, Arturo
Pedrazza, Leonardo
Lorenzo Martín, L. Francisco
Caloto, Rubén
Bustelo, Xosé R.
Ventura Pujol, Francesc
Rosa López, José Luis
author_role author
author2 Martinez-Martinez, Arturo
Pedrazza, Leonardo
Lorenzo Martín, L. Francisco
Caloto, Rubén
Bustelo, Xosé R.
Ventura Pujol, Francesc
Rosa López, José Luis
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genomes
Oncogens
Proteïnes supressores de tumors
Genomes
Oncogenes
Tumor suppressor protein
topic Genomes
Oncogens
Proteïnes supressores de tumors
Genomes
Oncogenes
Tumor suppressor protein
description HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/168599
url https://hdl.handle.net/2445/168599
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers12061653
Cancers, 2020, vol. 12, num. 6, p. E1653
https://doi.org/10.3390/cancers12061653
dc.rights.none.fl_str_mv cc-by (c) Sala Gaston, Joan et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sala Gaston, Joan et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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