Response of the human myocardium to ischemic injury and preconditioning

The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may...

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Autores: Casós, Kelly, Ferrer-Curriu, Gemma|||0000-0002-2651-649X, Soler-Ferrer, Paula, Pérez, María-Llanos, Permanyer, Eduard, Blasco-Lucas, Arnau|||0000-0002-2796-7428, Gracia Baena, Juan Manuel|||0000-0001-5277-3847, Castro, Miguel A., Sureda-Barbosa, Carlos, Barquinero Mañez, Jordi|||0000-0002-1677-9851, Galiñanes, Manuel|||0000-0002-0888-976X
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253857
Acceso en línea:https://ddd.uab.cat/record/253857
https://dx.doi.org/urn:doi:10.1371/journal.pone.0174588
Access Level:acceso abierto
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spelling Response of the human myocardium to ischemic injury and preconditioningThe role of cardiac and comorbid conditions, medical treatment, and basal redox statusCasós, KellyFerrer-Curriu, Gemma|||0000-0002-2651-649XSoler-Ferrer, PaulaPérez, María-LlanosPermanyer, EduardBlasco-Lucas, Arnau|||0000-0002-2796-7428Gracia Baena, Juan Manuel|||0000-0001-5277-3847Castro, Miguel A.Sureda-Barbosa, CarlosBarquinero Mañez, Jordi|||0000-0002-1677-9851Galiñanes, Manuel|||0000-0002-0888-976XThe diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. This study investigated the effect of both on myocardial susceptibility to I/R-induced injury and the protective effects of IPreC. Atrial myocardium from cardiac surgery patients (n = 300) was assigned to one of three groups: aerobic control, I/R alone, and IPreC. Lactate dehydrogenase leakage, as a marker of cell injury, and cell viability were measured. The basal redox status was determined in samples from 90 patients. The response to I/R varied widely. Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. Tissue from females was better protected than tissue from males. Myocardium from patients with mitral valve disease was the least responsive to IPreC. The basal redox status was altered in the myocardium from patients with mitral and aortic valve disease. The response of the myocardium to I/R and IPreC is highly variable and influenced by the underlying cardiac pathology, dyslipidemia, sex, and the basal redox status. These results should be taken into account in the design of future clinical studies on the prevention of I/R injury and protection.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253857https://dx.doi.org/urn:doi:10.1371/journal.pone.0174588reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 12/00119open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria.https://creativecommons.org/licenses/by-sa/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2538572026-06-06T12:50:31Z
dc.title.none.fl_str_mv Response of the human myocardium to ischemic injury and preconditioning
The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title Response of the human myocardium to ischemic injury and preconditioning
spellingShingle Response of the human myocardium to ischemic injury and preconditioning
Casós, Kelly
title_short Response of the human myocardium to ischemic injury and preconditioning
title_full Response of the human myocardium to ischemic injury and preconditioning
title_fullStr Response of the human myocardium to ischemic injury and preconditioning
title_full_unstemmed Response of the human myocardium to ischemic injury and preconditioning
title_sort Response of the human myocardium to ischemic injury and preconditioning
dc.creator.none.fl_str_mv Casós, Kelly
Ferrer-Curriu, Gemma|||0000-0002-2651-649X
Soler-Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco-Lucas, Arnau|||0000-0002-2796-7428
Gracia Baena, Juan Manuel|||0000-0001-5277-3847
Castro, Miguel A.
Sureda-Barbosa, Carlos
Barquinero Mañez, Jordi|||0000-0002-1677-9851
Galiñanes, Manuel|||0000-0002-0888-976X
author Casós, Kelly
author_facet Casós, Kelly
Ferrer-Curriu, Gemma|||0000-0002-2651-649X
Soler-Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco-Lucas, Arnau|||0000-0002-2796-7428
Gracia Baena, Juan Manuel|||0000-0001-5277-3847
Castro, Miguel A.
Sureda-Barbosa, Carlos
Barquinero Mañez, Jordi|||0000-0002-1677-9851
Galiñanes, Manuel|||0000-0002-0888-976X
author_role author
author2 Ferrer-Curriu, Gemma|||0000-0002-2651-649X
Soler-Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco-Lucas, Arnau|||0000-0002-2796-7428
Gracia Baena, Juan Manuel|||0000-0001-5277-3847
Castro, Miguel A.
Sureda-Barbosa, Carlos
Barquinero Mañez, Jordi|||0000-0002-1677-9851
Galiñanes, Manuel|||0000-0002-0888-976X
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
description The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. This study investigated the effect of both on myocardial susceptibility to I/R-induced injury and the protective effects of IPreC. Atrial myocardium from cardiac surgery patients (n = 300) was assigned to one of three groups: aerobic control, I/R alone, and IPreC. Lactate dehydrogenase leakage, as a marker of cell injury, and cell viability were measured. The basal redox status was determined in samples from 90 patients. The response to I/R varied widely. Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. Tissue from females was better protected than tissue from males. Myocardium from patients with mitral valve disease was the least responsive to IPreC. The basal redox status was altered in the myocardium from patients with mitral and aortic valve disease. The response of the myocardium to I/R and IPreC is highly variable and influenced by the underlying cardiac pathology, dyslipidemia, sex, and the basal redox status. These results should be taken into account in the design of future clinical studies on the prevention of I/R injury and protection.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253857
https://dx.doi.org/urn:doi:10.1371/journal.pone.0174588
url https://ddd.uab.cat/record/253857
https://dx.doi.org/urn:doi:10.1371/journal.pone.0174588
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 12/00119
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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