An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder

Background: One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation imp...

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Autores: Peña Arteaga, Víctor de la, Berruga Sánchez, Mercedes, Steward, Trevor, Martínez Zalacaín, Ignacio, Goldberg, Ximena, Wainsztein, Agustina, Abulafia, Carolina, Cardoner, N. (Narcís), Castro, Mariana N., Villarreal, Mirta, Menchón Magriñá, José Manuel, Guinjoan, Salvador M., Soriano Mas, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/180371
Acceso en línea:https://hdl.handle.net/2445/180371
Access Level:acceso abierto
Palabra clave:Diagnòstic per la imatge
Depressió psíquica
Trastorns de la personalitat
Diagnostic imaging
Depression, Mental
Personality disorders
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spelling An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorderPeña Arteaga, Víctor de laBerruga Sánchez, MercedesSteward, TrevorMartínez Zalacaín, IgnacioGoldberg, XimenaWainsztein, AgustinaAbulafia, CarolinaCardoner, N. (Narcís)Castro, Mariana N.Villarreal, MirtaMenchón Magriñá, José ManuelGuinjoan, Salvador M.Soriano Mas, CarlesDiagnòstic per la imatgeDepressió psíquicaTrastorns de la personalitatDiagnostic imagingDepression, MentalPersonality disordersBackground: One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations. Methods: We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity. Results: When compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions: This study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders.Cambridge University Press202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/180371Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https;//doi.org/10.1192/j.eurpsy.2021.2231European Psychiatry, 2021, vol 64, num. 1https;//doi.org/10.1192/j.eurpsy.2021.2231info:eu-repo/grantAgreement/EC/H2020/713673cc by-nc-nd (c) Peña Arteaga, Víctor de la et al, 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1803712026-05-29T05:05:01Z
dc.title.none.fl_str_mv An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
spellingShingle An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
Peña Arteaga, Víctor de la
Diagnòstic per la imatge
Depressió psíquica
Trastorns de la personalitat
Diagnostic imaging
Depression, Mental
Personality disorders
title_short An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_full An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_fullStr An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_full_unstemmed An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_sort An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
dc.creator.none.fl_str_mv Peña Arteaga, Víctor de la
Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina
Abulafia, Carolina
Cardoner, N. (Narcís)
Castro, Mariana N.
Villarreal, Mirta
Menchón Magriñá, José Manuel
Guinjoan, Salvador M.
Soriano Mas, Carles
author Peña Arteaga, Víctor de la
author_facet Peña Arteaga, Víctor de la
Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina
Abulafia, Carolina
Cardoner, N. (Narcís)
Castro, Mariana N.
Villarreal, Mirta
Menchón Magriñá, José Manuel
Guinjoan, Salvador M.
Soriano Mas, Carles
author_role author
author2 Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina
Abulafia, Carolina
Cardoner, N. (Narcís)
Castro, Mariana N.
Villarreal, Mirta
Menchón Magriñá, José Manuel
Guinjoan, Salvador M.
Soriano Mas, Carles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diagnòstic per la imatge
Depressió psíquica
Trastorns de la personalitat
Diagnostic imaging
Depression, Mental
Personality disorders
topic Diagnòstic per la imatge
Depressió psíquica
Trastorns de la personalitat
Diagnostic imaging
Depression, Mental
Personality disorders
description Background: One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations. Methods: We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity. Results: When compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions: This study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180371
url https://hdl.handle.net/2445/180371
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https;//doi.org/10.1192/j.eurpsy.2021.2231
European Psychiatry, 2021, vol 64, num. 1
https;//doi.org/10.1192/j.eurpsy.2021.2231
info:eu-repo/grantAgreement/EC/H2020/713673
dc.rights.none.fl_str_mv cc by-nc-nd (c) Peña Arteaga, Víctor de la et al, 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Peña Arteaga, Víctor de la et al, 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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