Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies

Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiol...

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Autores: Massó Rodriguez, Anna, Hogg, Bridget, Gardoki-Souto, Itxaso, Valiente Gómez, Alicia, Trabsa, Amira, Mosquera, Dolores, García-Estela, Aitana, Colom, Francesc, Pérez, Víctor, Padberg, Frank, Moreno Alcázar, Ana, Amann, Benedikt Lorenz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52544
Acceso en línea:http://hdl.handle.net/10230/52544
http://dx.doi.org/10.3389/fpsyt.2021.681876
Access Level:acceso abierto
Palabra clave:Affective continuum
Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
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spelling Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studiesMassó Rodriguez, AnnaHogg, BridgetGardoki-Souto, ItxasoValiente Gómez, AliciaTrabsa, AmiraMosquera, DoloresGarcía-Estela, AitanaColom, FrancescPérez, VíctorPadberg, FrankMoreno Alcázar, AnaAmann, Benedikt LorenzAffective continuumBipolar disorderBorderline personality disorderClinical featuresCognitive functionsNeuroimagingBackground: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268.Frontiers202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52544http://dx.doi.org/10.3389/fpsyt.2021.681876reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFront Psychiatry. 2021 Jun 9;12:681876© 2021 Massó Rodriguez, Hogg, Gardoki-Souto, Valiente-Gómez, Trabsa, Mosquera, García-Estela, Colom, Pérez, Padberg, Moreno-Alcázar and Amann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/525442026-06-12T07:21:37Z
dc.title.none.fl_str_mv Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
title Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
spellingShingle Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
Massó Rodriguez, Anna
Affective continuum
Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
title_short Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
title_full Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
title_fullStr Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
title_full_unstemmed Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
title_sort Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
dc.creator.none.fl_str_mv Massó Rodriguez, Anna
Hogg, Bridget
Gardoki-Souto, Itxaso
Valiente Gómez, Alicia
Trabsa, Amira
Mosquera, Dolores
García-Estela, Aitana
Colom, Francesc
Pérez, Víctor
Padberg, Frank
Moreno Alcázar, Ana
Amann, Benedikt Lorenz
author Massó Rodriguez, Anna
author_facet Massó Rodriguez, Anna
Hogg, Bridget
Gardoki-Souto, Itxaso
Valiente Gómez, Alicia
Trabsa, Amira
Mosquera, Dolores
García-Estela, Aitana
Colom, Francesc
Pérez, Víctor
Padberg, Frank
Moreno Alcázar, Ana
Amann, Benedikt Lorenz
author_role author
author2 Hogg, Bridget
Gardoki-Souto, Itxaso
Valiente Gómez, Alicia
Trabsa, Amira
Mosquera, Dolores
García-Estela, Aitana
Colom, Francesc
Pérez, Víctor
Padberg, Frank
Moreno Alcázar, Ana
Amann, Benedikt Lorenz
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Affective continuum
Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
topic Affective continuum
Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
description Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52544
http://dx.doi.org/10.3389/fpsyt.2021.681876
url http://hdl.handle.net/10230/52544
http://dx.doi.org/10.3389/fpsyt.2021.681876
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Front Psychiatry. 2021 Jun 9;12:681876
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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