The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review

BACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are at risk. Mutations in chromatin remodeling genes are more frequently found in...

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Autores: Casadevall Aguilar, David, Kilian, Anaïs Yacine, Bellmunt Molins, Joaquim, 1959-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34526
Acceso en línea:http://hdl.handle.net/10230/34526
http://dx.doi.org/10.1016/j.ctrv.2017.10.004
Access Level:acceso abierto
Palabra clave:Bufeta -- Càncer
Chromatin remodeling
Methylation
Non-coding RNA
Prognosis
Progression
Recurrence
Urothelial carcinoma
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spelling The prognostic role of epigenetic dysregulation in bladder cancer: A systematic reviewCasadevall Aguilar, DavidKilian, Anaïs YacineBellmunt Molins, Joaquim, 1959-Bufeta -- CàncerChromatin remodelingMethylationNon-coding RNAPrognosisProgressionRecurrenceUrothelial carcinomaBACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are at risk. Mutations in chromatin remodeling genes are more frequently found in bladder cancer than in any other solid tumor. However, the prognostic relevance of epigenetic dysregulation has not been established and may offer an opportunity for biomarker discovery. METHODS: Looking for prognostic epigenetic factors, we performed a comprehensive PubMed search using keywords such as "bladder cancer", "chromatin remodeling", "gene methylation" and "epigenetics". We only included studies reporting on the association of epigenetic markers with prognostic outcomes such as recurrence, progression or survival. RESULTS: Of 1113 results, 87 studies met the inclusion criteria, which represented a total of 85 epigenetic markers with potential prognostic relevance. No prospective studies were identified. Seventy-three percent (64/87) of the studies involved mixed cohorts of muscle invasive and non-muscle invasive bladder cancer. Promoter methylation of genes with putative prognostic value affected cellular processes such as cell cycle, apoptosis, cell-adhesion or migration, as well as critical pathways such as MAP-kinase or Wnt. Alteration of chromatin regulatory elements suggest a prognostic relevance alterations leading to a predominantly silenced chromatin state. CONCLUSIONS: The prognostic impact of epigenetic alterations in bladder cancer is still unclear. Prospective evaluation of methylation marks and chromatin remodeling gene alterations using consistent methods and criteria is warranted.Elsevier20182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34526http://dx.doi.org/10.1016/j.ctrv.2017.10.004reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCancer Treatment Reviews. 2017 Dec;61:82-93© Elsevier http://dx.doi.org/10.1016/j.ctrv.2017.10.004info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/345262026-06-12T07:21:37Z
dc.title.none.fl_str_mv The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
title The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
spellingShingle The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
Casadevall Aguilar, David
Bufeta -- Càncer
Chromatin remodeling
Methylation
Non-coding RNA
Prognosis
Progression
Recurrence
Urothelial carcinoma
title_short The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
title_full The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
title_fullStr The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
title_full_unstemmed The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
title_sort The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review
dc.creator.none.fl_str_mv Casadevall Aguilar, David
Kilian, Anaïs Yacine
Bellmunt Molins, Joaquim, 1959-
author Casadevall Aguilar, David
author_facet Casadevall Aguilar, David
Kilian, Anaïs Yacine
Bellmunt Molins, Joaquim, 1959-
author_role author
author2 Kilian, Anaïs Yacine
Bellmunt Molins, Joaquim, 1959-
author2_role author
author
dc.subject.none.fl_str_mv Bufeta -- Càncer
Chromatin remodeling
Methylation
Non-coding RNA
Prognosis
Progression
Recurrence
Urothelial carcinoma
topic Bufeta -- Càncer
Chromatin remodeling
Methylation
Non-coding RNA
Prognosis
Progression
Recurrence
Urothelial carcinoma
description BACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are at risk. Mutations in chromatin remodeling genes are more frequently found in bladder cancer than in any other solid tumor. However, the prognostic relevance of epigenetic dysregulation has not been established and may offer an opportunity for biomarker discovery. METHODS: Looking for prognostic epigenetic factors, we performed a comprehensive PubMed search using keywords such as "bladder cancer", "chromatin remodeling", "gene methylation" and "epigenetics". We only included studies reporting on the association of epigenetic markers with prognostic outcomes such as recurrence, progression or survival. RESULTS: Of 1113 results, 87 studies met the inclusion criteria, which represented a total of 85 epigenetic markers with potential prognostic relevance. No prospective studies were identified. Seventy-three percent (64/87) of the studies involved mixed cohorts of muscle invasive and non-muscle invasive bladder cancer. Promoter methylation of genes with putative prognostic value affected cellular processes such as cell cycle, apoptosis, cell-adhesion or migration, as well as critical pathways such as MAP-kinase or Wnt. Alteration of chromatin regulatory elements suggest a prognostic relevance alterations leading to a predominantly silenced chromatin state. CONCLUSIONS: The prognostic impact of epigenetic alterations in bladder cancer is still unclear. Prospective evaluation of methylation marks and chromatin remodeling gene alterations using consistent methods and criteria is warranted.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34526
http://dx.doi.org/10.1016/j.ctrv.2017.10.004
url http://hdl.handle.net/10230/34526
http://dx.doi.org/10.1016/j.ctrv.2017.10.004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancer Treatment Reviews. 2017 Dec;61:82-93
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.ctrv.2017.10.004
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.ctrv.2017.10.004
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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