Antitumor activities of metal oxide nanoparticles

Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle...

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Detalles Bibliográficos
Autores: Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans Arnal, Montserrat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/68520
Acceso en línea:https://hdl.handle.net/2445/68520
Access Level:acceso abierto
Palabra clave:Òxids metàl·lics
Nanopartícules
Càncer
Medicaments antineoplàstics
Metallic oxides
Nanoparticles
Cancer
Antineoplastic agents
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spelling Antitumor activities of metal oxide nanoparticlesVinardell Martínez-Hidalgo, Ma. PilarMitjans Arnal, MontserratÒxids metàl·licsNanopartículesCàncerMedicaments antineoplàsticsMetallic oxidesNanoparticlesCancerAntineoplastic agentsNanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some anticancer drugs. Zinc oxide nanoparticles have been shown to have this activity alone or when loaded with an anticancer drug, such as doxorubicin. Other nanoparticles that show cytotoxic effects on cancer cells include cobalt oxide, iron oxide and copper oxide. The antitumor mechanism could work through the generation of reactive oxygen species or apoptosis and necrosis, among other possibilities. Here, we review the most significant antitumor results obtained with different metal oxide nanoparticles.MDPI2015201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/68520Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.3390/nano5021004Nanomaterials, 2015, vol. 5, num. 2, p. 1004-1021http://dx.doi.org/10.3390/nano5021004cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/685202026-05-29T05:05:01Z
dc.title.none.fl_str_mv Antitumor activities of metal oxide nanoparticles
title Antitumor activities of metal oxide nanoparticles
spellingShingle Antitumor activities of metal oxide nanoparticles
Vinardell Martínez-Hidalgo, Ma. Pilar
Òxids metàl·lics
Nanopartícules
Càncer
Medicaments antineoplàstics
Metallic oxides
Nanoparticles
Cancer
Antineoplastic agents
title_short Antitumor activities of metal oxide nanoparticles
title_full Antitumor activities of metal oxide nanoparticles
title_fullStr Antitumor activities of metal oxide nanoparticles
title_full_unstemmed Antitumor activities of metal oxide nanoparticles
title_sort Antitumor activities of metal oxide nanoparticles
dc.creator.none.fl_str_mv Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
author Vinardell Martínez-Hidalgo, Ma. Pilar
author_facet Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
author_role author
author2 Mitjans Arnal, Montserrat
author2_role author
dc.subject.none.fl_str_mv Òxids metàl·lics
Nanopartícules
Càncer
Medicaments antineoplàstics
Metallic oxides
Nanoparticles
Cancer
Antineoplastic agents
topic Òxids metàl·lics
Nanopartícules
Càncer
Medicaments antineoplàstics
Metallic oxides
Nanoparticles
Cancer
Antineoplastic agents
description Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some anticancer drugs. Zinc oxide nanoparticles have been shown to have this activity alone or when loaded with an anticancer drug, such as doxorubicin. Other nanoparticles that show cytotoxic effects on cancer cells include cobalt oxide, iron oxide and copper oxide. The antitumor mechanism could work through the generation of reactive oxygen species or apoptosis and necrosis, among other possibilities. Here, we review the most significant antitumor results obtained with different metal oxide nanoparticles.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/68520
url https://hdl.handle.net/2445/68520
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3390/nano5021004
Nanomaterials, 2015, vol. 5, num. 2, p. 1004-1021
http://dx.doi.org/10.3390/nano5021004
dc.rights.none.fl_str_mv cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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