Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

ObjectivesTo compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. MethodsARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, cli...

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Autores: Molina-Collada, J, Domínguez-Alvaro, M, Melero-González, RB, de Miguel, E, Silva-Díaz, M, Jaimes, JAV, González, I, Martín, JS, Narváez, J, Calvet, J, Casafont-Solé, I, Ivorra, JAR, Arrabal, SL, Rocha, MV, Iñiguez, CL, Reyes, MSB, Fernández, CC, Villar, MA, Mas, AJ, Blanco, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5417
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/5417
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214356540&doi=10.1186%2Fs13075-024-03468-6&partnerID=40&md5=1d5116ad835c8dad983fa4f87281f9ad
Access Level:acceso abierto
Palabra clave:Mortality
Survival
Giant cell arteritis
Vasculitis
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spelling Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registryMolina-Collada, JDomínguez-Alvaro, MMelero-González, RBde Miguel, ESilva-Díaz, MJaimes, JAVGonzález, IMartín, JSNarváez, JCalvet, JCasafont-Solé, IIvorra, JARArrabal, SLRocha, MVIñiguez, CLReyes, MSBFernández, CCVillar, MAMas, AJBlanco, RMortalitySurvivalGiant cell arteritisVasculitisObjectivesTo compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. MethodsARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. ResultsA total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. ConclusionsThe overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.BMC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5417https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214356540&doi=10.1186%2Fs13075-024-03468-6&partnerID=40&md5=1d5116ad835c8dad983fa4f87281f9adARTHRITIS RESEARCH & THERAPYISSN: 14786354ISSNe: 14786362reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p54172026-06-21T15:30:37Z
dc.title.none.fl_str_mv Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
spellingShingle Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
Molina-Collada, J
Mortality
Survival
Giant cell arteritis
Vasculitis
title_short Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_full Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_fullStr Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_full_unstemmed Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_sort Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
dc.creator.none.fl_str_mv Molina-Collada, J
Domínguez-Alvaro, M
Melero-González, RB
de Miguel, E
Silva-Díaz, M
Jaimes, JAV
González, I
Martín, JS
Narváez, J
Calvet, J
Casafont-Solé, I
Ivorra, JAR
Arrabal, SL
Rocha, MV
Iñiguez, CL
Reyes, MSB
Fernández, CC
Villar, MA
Mas, AJ
Blanco, R
author Molina-Collada, J
author_facet Molina-Collada, J
Domínguez-Alvaro, M
Melero-González, RB
de Miguel, E
Silva-Díaz, M
Jaimes, JAV
González, I
Martín, JS
Narváez, J
Calvet, J
Casafont-Solé, I
Ivorra, JAR
Arrabal, SL
Rocha, MV
Iñiguez, CL
Reyes, MSB
Fernández, CC
Villar, MA
Mas, AJ
Blanco, R
author_role author
author2 Domínguez-Alvaro, M
Melero-González, RB
de Miguel, E
Silva-Díaz, M
Jaimes, JAV
González, I
Martín, JS
Narváez, J
Calvet, J
Casafont-Solé, I
Ivorra, JAR
Arrabal, SL
Rocha, MV
Iñiguez, CL
Reyes, MSB
Fernández, CC
Villar, MA
Mas, AJ
Blanco, R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mortality
Survival
Giant cell arteritis
Vasculitis
topic Mortality
Survival
Giant cell arteritis
Vasculitis
description ObjectivesTo compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. MethodsARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. ResultsA total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. ConclusionsThe overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5417
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214356540&doi=10.1186%2Fs13075-024-03468-6&partnerID=40&md5=1d5116ad835c8dad983fa4f87281f9ad
url https://i3pt.portalinvestigacion.com/publicaciones/5417
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214356540&doi=10.1186%2Fs13075-024-03468-6&partnerID=40&md5=1d5116ad835c8dad983fa4f87281f9ad
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv ARTHRITIS RESEARCH & THERAPY
ISSN: 14786354
ISSNe: 14786362
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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