From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus

With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the effor...

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Autores: Aledavood, Elnaz, Selmi, Beatrice, Estarellas, Carolina, Masetti, Matteo, Luque Garriga, F. Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183950
Acceso en línea:https://hdl.handle.net/2445/183950
Access Level:acceso abierto
Palabra clave:Influenzavirus
Química orgànica
Virus
Influenza viruses
Organic chemistry
Viruses
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spelling From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A VirusAledavood, ElnazSelmi, BeatriceEstarellas, CarolinaMasetti, MatteoLuque Garriga, F. XavierInfluenzavirusQuímica orgànicaVirusInfluenza virusesOrganic chemistryVirusesWith an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains.Frontiers Media2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183950Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fmolb.2021.796229Frontiers In Molecular Biosciences, 2022, vol. 8, p. 796229https://doi.org/10.3389/fmolb.2021.796229cc-by (c) Aledavood, Elnaz et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1839502026-05-27T06:46:51Z
dc.title.none.fl_str_mv From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
title From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
spellingShingle From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
Aledavood, Elnaz
Influenzavirus
Química orgànica
Virus
Influenza viruses
Organic chemistry
Viruses
title_short From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
title_full From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
title_fullStr From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
title_full_unstemmed From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
title_sort From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
dc.creator.none.fl_str_mv Aledavood, Elnaz
Selmi, Beatrice
Estarellas, Carolina
Masetti, Matteo
Luque Garriga, F. Xavier
author Aledavood, Elnaz
author_facet Aledavood, Elnaz
Selmi, Beatrice
Estarellas, Carolina
Masetti, Matteo
Luque Garriga, F. Xavier
author_role author
author2 Selmi, Beatrice
Estarellas, Carolina
Masetti, Matteo
Luque Garriga, F. Xavier
author2_role author
author
author
author
dc.subject.none.fl_str_mv Influenzavirus
Química orgànica
Virus
Influenza viruses
Organic chemistry
Viruses
topic Influenzavirus
Química orgànica
Virus
Influenza viruses
Organic chemistry
Viruses
description With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183950
url https://hdl.handle.net/2445/183950
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fmolb.2021.796229
Frontiers In Molecular Biosciences, 2022, vol. 8, p. 796229
https://doi.org/10.3389/fmolb.2021.796229
dc.rights.none.fl_str_mv cc-by (c) Aledavood, Elnaz et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Aledavood, Elnaz et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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