Environmental enrichment induces epigenomic and genome organization changes relevant for cognition

In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrich...

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Bibliographic Details
Authors: Espeso Gil, Sergio, 1985-, Holik, Aliaksei Z., Bonnin, Sarah, Jhanwar, Shalu, 1986-, Chandrasekaran, Sandhya, Pique Regi, Roger, Albaigès-Ràfols, Júlia, Maher, Michael, Permanyer, Jon, Irimia Martínez, Manuel, Friedländer, Marc R., Pons Espinal, Meritxell, 1986-, Akbarian, Schahram, Dierssen, Mara, Maass, Philipp G., Hor, Charlotte N., Ossowski, Stephan
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/49052
Online Access:http://hdl.handle.net/10230/49052
http://dx.doi.org/10.3389/fnmol.2021.664912
Access Level:Open access
Keyword:3D genome organization
Hi-C
Chromatin accessibility
Environmental enrichment
Epigenetics
Inter-chromosomal contacts
Learning
Postnatal development
Description
Summary:In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization.

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