IC50 of trifluoperazine and RMI 12330A for the Theophylline and Phloretin - lnduced lncrease in Intestinal D-Galactose Accumulation

The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10- 6 M. These fin...

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Detalles Bibliográficos
Autores: Ilundáin Larrañeta, María Anunciación Ana, Alcalde Herrero, Ana Isabel, Barcina Angulo, Yolanda, Larralde, J.
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:1987
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/32927
Acceso en línea:http://hdl.handle.net/11441/32927
Access Level:acceso abierto
Palabra clave:Trifluoperazine
RMI 12330A
lntestine
Sugar transpon
Descripción
Sumario:The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10- 6 M. These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transpon in intact rat ilcum.

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