Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)

Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to...

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Detalles Bibliográficos
Autores: Pedersen, Marie, Sunyer Deu, Jordi, Mendez, Michelle A., Espinosa, Aina, Agramunt, Silvia, Kogevinas, Manolis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/23373
Acceso en línea:http://hdl.handle.net/10230/23373
http://dx.doi.org/10.1289/ehp.1206333
Access Level:acceso abierto
Palabra clave:Embaràs Aspectes nutricionals
ADN
Infants nadons -- Malalties
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spelling Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)Pedersen, MarieSunyer Deu, JordiMendez, Michelle A.Espinosa, AinaAgramunt, SilviaKogevinas, ManolisEmbaràs Aspectes nutricionalsADNInfants nadons -- MalaltiesBackground: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to several genotoxic agents including PAHs. Objectives: We estimated the association between bulky DNA adduct levels and birth weight in a multicenter study and examined modification of this association by maternal intake of fruits and vegetables during pregnancy. Methods: Pregnant women from Denmark, England, Greece, Norway, and Spain were recruited in 2006–2010. Adduct levels were measured by the 32P-postlabeling technique in white blood cells from 229 mothers and 612 newborns. Maternal diet was examined through questionnaires. Results: Adduct levels in maternal and cord blood samples were similar and positively correlated (median, 12.1 vs. 11.4 adducts in 108 nucleotides; Spearman rank correlation coefficient = 0.66, p < 0.001). Cord blood adduct levels were negatively associated with birth weight, with an estimated difference in mean birth weight of –129 g (95% CI: –233, –25 g) for infants in the highest versus lowest tertile of adducts. The negative association with birth weight was limited to births in Norway, Denmark, and England, the countries with the lowest adduct levels, and was more pronounced in births to mothers with low intake of fruits and vegetables (–248 g; 95% CI: –405, –92 g) compared with those with high intake (–58 g; 95% CI: –206, 90 g). Conclusions: Maternal exposure to genotoxic agents that induce the formation of bulky DNA adducts may affect intrauterine growth. Maternal fruit and vegetable consumption may be protective.The NewGeneris (Newborns and Genotoxic exposure risks) study was funded by the European Union (EU contract FOOD-CT-2005-016320). The study/nwas also supported by the National Institute for Health Research, United Kingdom (programme grant RP-PG-0407-10044), the Norwegian Ministry of/nHealth, the Norwegian Ministry of Education and Research, the Norwegian Research Council/FUGE (grant 151918/S10), the EU funded HiWATE (contract Food-CT-2006-036224), the U.S. National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (contract NO-ES-75558), and the U.S. NIH/National Institute of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01). M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479)National Institute of Environmental Health Sciences (NIEHS)201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23373http://dx.doi.org/10.1289/ehp.1206333reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironmental Health Perspectives. 2013;121(10):1200-6info:eu-repo/grantAgreement/EC/FP6/016320info:eu-repo/grantAgreement/EC/FP6/036224info:eu-repo/grantAgreement/ES/3PN/JCI2011-09479Reproduced with permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/233732026-06-12T07:21:37Z
dc.title.none.fl_str_mv Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
title Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
spellingShingle Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
Pedersen, Marie
Embaràs Aspectes nutricionals
ADN
Infants nadons -- Malalties
title_short Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
title_full Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
title_fullStr Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
title_full_unstemmed Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
title_sort Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
dc.creator.none.fl_str_mv Pedersen, Marie
Sunyer Deu, Jordi
Mendez, Michelle A.
Espinosa, Aina
Agramunt, Silvia
Kogevinas, Manolis
author Pedersen, Marie
author_facet Pedersen, Marie
Sunyer Deu, Jordi
Mendez, Michelle A.
Espinosa, Aina
Agramunt, Silvia
Kogevinas, Manolis
author_role author
author2 Sunyer Deu, Jordi
Mendez, Michelle A.
Espinosa, Aina
Agramunt, Silvia
Kogevinas, Manolis
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Embaràs Aspectes nutricionals
ADN
Infants nadons -- Malalties
topic Embaràs Aspectes nutricionals
ADN
Infants nadons -- Malalties
description Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to several genotoxic agents including PAHs. Objectives: We estimated the association between bulky DNA adduct levels and birth weight in a multicenter study and examined modification of this association by maternal intake of fruits and vegetables during pregnancy. Methods: Pregnant women from Denmark, England, Greece, Norway, and Spain were recruited in 2006–2010. Adduct levels were measured by the 32P-postlabeling technique in white blood cells from 229 mothers and 612 newborns. Maternal diet was examined through questionnaires. Results: Adduct levels in maternal and cord blood samples were similar and positively correlated (median, 12.1 vs. 11.4 adducts in 108 nucleotides; Spearman rank correlation coefficient = 0.66, p < 0.001). Cord blood adduct levels were negatively associated with birth weight, with an estimated difference in mean birth weight of –129 g (95% CI: –233, –25 g) for infants in the highest versus lowest tertile of adducts. The negative association with birth weight was limited to births in Norway, Denmark, and England, the countries with the lowest adduct levels, and was more pronounced in births to mothers with low intake of fruits and vegetables (–248 g; 95% CI: –405, –92 g) compared with those with high intake (–58 g; 95% CI: –206, 90 g). Conclusions: Maternal exposure to genotoxic agents that induce the formation of bulky DNA adducts may affect intrauterine growth. Maternal fruit and vegetable consumption may be protective.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23373
http://dx.doi.org/10.1289/ehp.1206333
url http://hdl.handle.net/10230/23373
http://dx.doi.org/10.1289/ehp.1206333
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2013;121(10):1200-6
info:eu-repo/grantAgreement/EC/FP6/016320
info:eu-repo/grantAgreement/EC/FP6/036224
info:eu-repo/grantAgreement/ES/3PN/JCI2011-09479
dc.rights.none.fl_str_mv Reproduced with permission from Environmental Health Perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced with permission from Environmental Health Perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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