Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish

Monoaminergic neurotransmitters are the main components that regulate of a lot of processes in the vertebrate brain. There is growing interest to monitor the changes produced in these neurochemicals due to the large number of exogenous agents, such as pharmaceuticals and drugs of abuse, targeting an...

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Detalles Bibliográficos
Autores: Mayol Cabré, Marta, Prats, Eva, Raldúa, Demetrio, Gómez-Canela, Cristian
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/4801
Acceso en línea:http://hdl.handle.net/20.500.14342/4801
https://doi.org/10.1016/j.scitotenv.2020.141205
Access Level:acceso abierto
Palabra clave:Adult zebrafish
Brain
Neurotransmitters
Liquid chromatography
Tandem mass spectrometry
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spelling Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafishMayol Cabré, MartaPrats, EvaRaldúa, DemetrioGómez-Canela, CristianAdult zebrafishBrainNeurotransmittersLiquid chromatographyTandem mass spectrometry5Monoaminergic neurotransmitters are the main components that regulate of a lot of processes in the vertebrate brain. There is growing interest to monitor the changes produced in these neurochemicals due to the large number of exogenous agents, such as pharmaceuticals and drugs of abuse, targeting and affecting this system. Adult zebrafish (Danio rerio) shares the common neurotransmitter pathways and nervous system organization with mammals. Therefore, a method based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has been developed for the first time to study the profile of ten monoaminergic neurochemicals in the anterior, middle and posterior brain regions of adult zebrafish. Moreover, the applied LC-MS/MS method has been studied in terms of quality such as linearity, sensitivity and intra- and inter-day precision. The analytical method based in LC-MS/MS has become a new source in neurotoxicology using adult zebrafish as research model. Significant differences on the levels of these neurotransmitters have been found between the different brain regions. Capsule The profile of ten monoaminergic neurochemicals in the main three brain areas of adult zebrafish has been reported for the first time in this manuscript.info:eu-repo/semantics/acceptedVersionElsevierUniversitat Ramon Llull. IQS202520252020info:eu-repo/semantics/article25 p.application/pdfhttp://hdl.handle.net/20.500.14342/4801https://doi.org/10.1016/j.scitotenv.2020.141205reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésScience of The Total Environment. 2020;745:141205info:eu-repo/grantAgreement/MICINN/PN I+D/CTM2017-83242-Rinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 902info:eu-repo/grantAgreement/URL/Projectes recerca PDI/2019-URL-Proj-013© ElsevierAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/48012026-06-21T06:40:37Z
dc.title.none.fl_str_mv Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
title Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
spellingShingle Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
Mayol Cabré, Marta
Adult zebrafish
Brain
Neurotransmitters
Liquid chromatography
Tandem mass spectrometry
5
title_short Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
title_full Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
title_fullStr Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
title_full_unstemmed Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
title_sort Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
dc.creator.none.fl_str_mv Mayol Cabré, Marta
Prats, Eva
Raldúa, Demetrio
Gómez-Canela, Cristian
author Mayol Cabré, Marta
author_facet Mayol Cabré, Marta
Prats, Eva
Raldúa, Demetrio
Gómez-Canela, Cristian
author_role author
author2 Prats, Eva
Raldúa, Demetrio
Gómez-Canela, Cristian
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Adult zebrafish
Brain
Neurotransmitters
Liquid chromatography
Tandem mass spectrometry
5
topic Adult zebrafish
Brain
Neurotransmitters
Liquid chromatography
Tandem mass spectrometry
5
description Monoaminergic neurotransmitters are the main components that regulate of a lot of processes in the vertebrate brain. There is growing interest to monitor the changes produced in these neurochemicals due to the large number of exogenous agents, such as pharmaceuticals and drugs of abuse, targeting and affecting this system. Adult zebrafish (Danio rerio) shares the common neurotransmitter pathways and nervous system organization with mammals. Therefore, a method based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has been developed for the first time to study the profile of ten monoaminergic neurochemicals in the anterior, middle and posterior brain regions of adult zebrafish. Moreover, the applied LC-MS/MS method has been studied in terms of quality such as linearity, sensitivity and intra- and inter-day precision. The analytical method based in LC-MS/MS has become a new source in neurotoxicology using adult zebrafish as research model. Significant differences on the levels of these neurotransmitters have been found between the different brain regions. Capsule The profile of ten monoaminergic neurochemicals in the main three brain areas of adult zebrafish has been reported for the first time in this manuscript.
publishDate 2020
dc.date.none.fl_str_mv 2020
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/4801
https://doi.org/10.1016/j.scitotenv.2020.141205
url http://hdl.handle.net/20.500.14342/4801
https://doi.org/10.1016/j.scitotenv.2020.141205
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Science of The Total Environment. 2020;745:141205
info:eu-repo/grantAgreement/MICINN/PN I+D/CTM2017-83242-R
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 902
info:eu-repo/grantAgreement/URL/Projectes recerca PDI/2019-URL-Proj-013
dc.rights.none.fl_str_mv © Elsevier
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 25 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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