The role of herpes simplex virus type 1 infection in demyelination of the central nervous system

Herpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The vi...

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Detalles Bibliográficos
Autores: Andreu, Sabina, Bello-Morales Arroyo, Ángeles Raquel, López Guerrero, José Antonio
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708875
Acceso en línea:http://hdl.handle.net/10486/708875
https://dx.doi.org/10.3390/ijms21145026
Access Level:acceso abierto
Palabra clave:Central nervous system
Demyelination
Endogenous retroviruses
HSV-1
Molecular mimicry
Oligodendrocytes
Peripheral nervous system
Biología y Biomedicina / Biología
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spelling The role of herpes simplex virus type 1 infection in demyelination of the central nervous systemAndreu, SabinaBello-Morales Arroyo, Ángeles RaquelLópez Guerrero, José AntonioCentral nervous systemDemyelinationEndogenous retrovirusesHSV-1Molecular mimicryOligodendrocytesPeripheral nervous systemBiología y Biomedicina / BiologíaHerpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The virus can reactivate from the latent state, traveling anterogradely along the axon and replicating in the local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from the TG to the brainstem, from where it may disseminate to higher areas of the central nervous system (CNS). It is not completely understood how HSV-1 reaches the CNS, although the most accepted idea is retrograde transport through the trigeminal or olfactory tracts. Once in the CNS, HSV-1 may induce demyelination, either as a direct trigger or as a risk factor, modulating processes such as remyelination, regulation of endogenous retroviruses, or molecular mimicry. In this review, we describe the current knowledge about the involvement of HSV-1 in demyelination, describing the pathways used by this herpesvirus to spread throughout the CNS and discussing the data that suggest its implication in demyelinating processesFinancial support for the study was provided by Fundación Severo Ochoa-Aeromédica Canaria. The funders had no role in the decision to publish or preparation of the manuscriptMultidisciplinary Digital Publishing InstituteDepartamento de Biología MolecularFacultad de Ciencias20202020-07-16research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708875https://dx.doi.org/10.3390/ijms21145026reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7088752026-06-23T12:46:27Z
dc.title.none.fl_str_mv The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
title The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
spellingShingle The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
Andreu, Sabina
Central nervous system
Demyelination
Endogenous retroviruses
HSV-1
Molecular mimicry
Oligodendrocytes
Peripheral nervous system
Biología y Biomedicina / Biología
title_short The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
title_full The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
title_fullStr The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
title_full_unstemmed The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
title_sort The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
dc.creator.none.fl_str_mv Andreu, Sabina
Bello-Morales Arroyo, Ángeles Raquel
López Guerrero, José Antonio
author Andreu, Sabina
author_facet Andreu, Sabina
Bello-Morales Arroyo, Ángeles Raquel
López Guerrero, José Antonio
author_role author
author2 Bello-Morales Arroyo, Ángeles Raquel
López Guerrero, José Antonio
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Central nervous system
Demyelination
Endogenous retroviruses
HSV-1
Molecular mimicry
Oligodendrocytes
Peripheral nervous system
Biología y Biomedicina / Biología
topic Central nervous system
Demyelination
Endogenous retroviruses
HSV-1
Molecular mimicry
Oligodendrocytes
Peripheral nervous system
Biología y Biomedicina / Biología
description Herpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The virus can reactivate from the latent state, traveling anterogradely along the axon and replicating in the local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from the TG to the brainstem, from where it may disseminate to higher areas of the central nervous system (CNS). It is not completely understood how HSV-1 reaches the CNS, although the most accepted idea is retrograde transport through the trigeminal or olfactory tracts. Once in the CNS, HSV-1 may induce demyelination, either as a direct trigger or as a risk factor, modulating processes such as remyelination, regulation of endogenous retroviruses, or molecular mimicry. In this review, we describe the current knowledge about the involvement of HSV-1 in demyelination, describing the pathways used by this herpesvirus to spread throughout the CNS and discussing the data that suggest its implication in demyelinating processes
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-07-16
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708875
https://dx.doi.org/10.3390/ijms21145026
url http://hdl.handle.net/10486/708875
https://dx.doi.org/10.3390/ijms21145026
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
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