AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease
CD5L, a soluble protein belonging to the scavenger receptor cysteine-rich superfamily, is expressed mostly by macrophages in both lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by liver X receptors, members of the nuclear receptor family that play major...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/222614 |
| Acceso en línea: | https://hdl.handle.net/2445/222614 |
| Access Level: | acceso abierto |
| Palabra clave: | Resposta immunitària Macròfags Aterosclerosi Cirrosi hepàtica Immune response Macrophages Atherosclerosis Hepatic cirrhosis |
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AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory diseaseSanjurjo, LucíaAran, GemmaRoher, NereaValledor Fernandez, AnnabelSarrias Fornés, Maria RosaResposta immunitàriaMacròfagsAterosclerosiCirrosi hepàticaImmune responseMacrophagesAtherosclerosisHepatic cirrhosisCD5L, a soluble protein belonging to the scavenger receptor cysteine-rich superfamily, is expressed mostly by macrophages in both lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by liver X receptors, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a pattern recognition receptor of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as tuberculosis and liver cirrhosis. Oxford University Press2025202520152025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion12 p.application/pdfhttps://hdl.handle.net/2445/222614Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1189/jlb.3RU0215-074RJournal of Leukocyte Biology, 2015, vol. 98, num.2, p. 173-184https://doi.org/10.1189/jlb.3RU0215-074R© 2015 Society for Leukocyte Biologyinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/2226142026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| title |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| spellingShingle |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease Sanjurjo, Lucía Resposta immunitària Macròfags Aterosclerosi Cirrosi hepàtica Immune response Macrophages Atherosclerosis Hepatic cirrhosis |
| title_short |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| title_full |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| title_fullStr |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| title_full_unstemmed |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| title_sort |
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease |
| dc.creator.none.fl_str_mv |
Sanjurjo, Lucía Aran, Gemma Roher, Nerea Valledor Fernandez, Annabel Sarrias Fornés, Maria Rosa |
| author |
Sanjurjo, Lucía |
| author_facet |
Sanjurjo, Lucía Aran, Gemma Roher, Nerea Valledor Fernandez, Annabel Sarrias Fornés, Maria Rosa |
| author_role |
author |
| author2 |
Aran, Gemma Roher, Nerea Valledor Fernandez, Annabel Sarrias Fornés, Maria Rosa |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Resposta immunitària Macròfags Aterosclerosi Cirrosi hepàtica Immune response Macrophages Atherosclerosis Hepatic cirrhosis |
| topic |
Resposta immunitària Macròfags Aterosclerosi Cirrosi hepàtica Immune response Macrophages Atherosclerosis Hepatic cirrhosis |
| description |
CD5L, a soluble protein belonging to the scavenger receptor cysteine-rich superfamily, is expressed mostly by macrophages in both lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by liver X receptors, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a pattern recognition receptor of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as tuberculosis and liver cirrhosis. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/222614 |
| url |
https://hdl.handle.net/2445/222614 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1189/jlb.3RU0215-074R Journal of Leukocyte Biology, 2015, vol. 98, num.2, p. 173-184 https://doi.org/10.1189/jlb.3RU0215-074R |
| dc.rights.none.fl_str_mv |
© 2015 Society for Leukocyte Biology info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
© 2015 Society for Leukocyte Biology |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
12 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
| publisher.none.fl_str_mv |
Oxford University Press |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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|
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1869418944533626880 |
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15.812455 |