Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study

The present work aimed at studying the in vitro digestion fate of κ-carrageenan (KC) or agar (AG) emulsion gels (EG), and KC oil-filled aerogels (OAG) in terms of their structural changes, lipolysis kinetics and curcumin bioaccessibility. On the one hand, both EG and aerogels showed large (70-200 µm...

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Detalles Bibliográficos
Autores: Velderrain-Rodríguez, Gustavo, Fontes Candia, Cynthia, López-Rubio, Amparo, Martínez Sanz, Marta, Martín-Belloso, Olga, Salvia Trujillo, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/311304
Acceso en línea:http://hdl.handle.net/10261/311304
https://api.elsevier.com/content/abstract/scopus_id/85159415928
Access Level:acceso abierto
Palabra clave:Aerogels
Bioaccessibility
Curcumin
Emulsion gels
Lipid digestibility
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spelling Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion studyVelderrain-Rodríguez, GustavoFontes Candia, CynthiaLópez-Rubio, AmparoMartínez Sanz, MartaMartín-Belloso, OlgaSalvia Trujillo, LauraAerogelsBioaccessibilityCurcuminEmulsion gelsLipid digestibilityThe present work aimed at studying the in vitro digestion fate of κ-carrageenan (KC) or agar (AG) emulsion gels (EG), and KC oil-filled aerogels (OAG) in terms of their structural changes, lipolysis kinetics and curcumin bioaccessibility. On the one hand, both EG and aerogels showed large (70-200 µm) and heterogeneous particles after gastric conditions, indicating the release of bulk oil and gelled material. Nonetheless, this material release in the stomach phase was lower in the case of EG-AG and OAG-KC compared to EG-KC. After small intestinal conditions, EG and oil-filled aerogels presented a wide range of particle sizes probably due to the presence of undigested lipid material, gelled structures, as well as lipid digestion products. For the most part, adding curcumin to the structures' lipid phase did not cause of the structural modifications that occurred at the different in vitro digestion phases. On the other hand, the lipolysis kinetics was different depending on the type of structure. Amongst emulsion-gels, those formulated with κ-carrageenan presented a slower and lower lipolysis kinetics compared to those formulated with agar, which could be attributed to their higher initial hardness. Overall, the addition of curcumin in the lipid phase decreased the lipolysis in all the structures, which evidenced its interference in the lipid digestion process. The curcumin bioaccessibility reached high values (≈ 100 %) for all the studied structures, presenting a high solubility in intestinal fluids. This work unravels the implications of microstructural changes of emulsion-gels and oil-filled aerogels during digestion and their impact on their digestibility and subsequent functionality.This study was funded by the Ministry of Science, Innovation and Universities throughout the projects RTI2018–094268-B-C21 (University of Lleida) and RTI2018–094268-B-C22 (Agencia Estatal Consejo Superior de Investigaciones Cientificas (CSIC)).Peer reviewedElsevierAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas (España)Universidad de Lleida0000-0003-2981-25310000-0001-6469-94020000-0001-7168-52870000-0002-7027-69720000-0001-8662-4989Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/311304https://api.elsevier.com/content/abstract/scopus_id/85159415928reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094268-B-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094268-B-C22The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.colsurfb.2023.113349https://doi.org/10.1016/j.colsurfb.2023.113349Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3113042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
title Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
spellingShingle Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
Velderrain-Rodríguez, Gustavo
Aerogels
Bioaccessibility
Curcumin
Emulsion gels
Lipid digestibility
title_short Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
title_full Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
title_fullStr Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
title_full_unstemmed Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
title_sort Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study
dc.creator.none.fl_str_mv Velderrain-Rodríguez, Gustavo
Fontes Candia, Cynthia
López-Rubio, Amparo
Martínez Sanz, Marta
Martín-Belloso, Olga
Salvia Trujillo, Laura
author Velderrain-Rodríguez, Gustavo
author_facet Velderrain-Rodríguez, Gustavo
Fontes Candia, Cynthia
López-Rubio, Amparo
Martínez Sanz, Marta
Martín-Belloso, Olga
Salvia Trujillo, Laura
author_role author
author2 Fontes Candia, Cynthia
López-Rubio, Amparo
Martínez Sanz, Marta
Martín-Belloso, Olga
Salvia Trujillo, Laura
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas (España)
Universidad de Lleida
0000-0003-2981-2531
0000-0001-6469-9402
0000-0001-7168-5287
0000-0002-7027-6972
0000-0001-8662-4989
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aerogels
Bioaccessibility
Curcumin
Emulsion gels
Lipid digestibility
topic Aerogels
Bioaccessibility
Curcumin
Emulsion gels
Lipid digestibility
description The present work aimed at studying the in vitro digestion fate of κ-carrageenan (KC) or agar (AG) emulsion gels (EG), and KC oil-filled aerogels (OAG) in terms of their structural changes, lipolysis kinetics and curcumin bioaccessibility. On the one hand, both EG and aerogels showed large (70-200 µm) and heterogeneous particles after gastric conditions, indicating the release of bulk oil and gelled material. Nonetheless, this material release in the stomach phase was lower in the case of EG-AG and OAG-KC compared to EG-KC. After small intestinal conditions, EG and oil-filled aerogels presented a wide range of particle sizes probably due to the presence of undigested lipid material, gelled structures, as well as lipid digestion products. For the most part, adding curcumin to the structures' lipid phase did not cause of the structural modifications that occurred at the different in vitro digestion phases. On the other hand, the lipolysis kinetics was different depending on the type of structure. Amongst emulsion-gels, those formulated with κ-carrageenan presented a slower and lower lipolysis kinetics compared to those formulated with agar, which could be attributed to their higher initial hardness. Overall, the addition of curcumin in the lipid phase decreased the lipolysis in all the structures, which evidenced its interference in the lipid digestion process. The curcumin bioaccessibility reached high values (≈ 100 %) for all the studied structures, presenting a high solubility in intestinal fluids. This work unravels the implications of microstructural changes of emulsion-gels and oil-filled aerogels during digestion and their impact on their digestibility and subsequent functionality.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/311304
https://api.elsevier.com/content/abstract/scopus_id/85159415928
url http://hdl.handle.net/10261/311304
https://api.elsevier.com/content/abstract/scopus_id/85159415928
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094268-B-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094268-B-C22
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.colsurfb.2023.113349
https://doi.org/10.1016/j.colsurfb.2023.113349
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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