Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
Purpose A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment...
| Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2018 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/65871 |
| Online Access: | https://hdl.handle.net/10171/65871 |
| Access Level: | Open access |
| Keyword: | FDG-PET Primary progressive aphasia PPA Neurodegenerative Semantic Logopenic Agrammatic Dementia |
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Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasiaBouwman, F. (Femke)|||/items/9d0a94af-dd86-4441-80ac-fa599a87bd88Orini, S. (Stefania)|||/items/66ab2a2b-6379-4096-b2be-cce227a0c90aGandolfo, F. (Federica)|||/items/0278f7e0-fb9c-4ff2-bbbc-060cbff029b7Altomare, D. (Daniele)|||/items/fec9e5e8-6437-4fc5-a71b-29b544b54c78Festari, C. (Cristina)|||/items/1560adcc-2199-42d4-a748-317862cc4260Agosta, F. (Federica)|||/items/6f2f430b-eba8-41e3-9942-67cbe06b03eeDrzezga, A. (Alexander)|||/items/a72faedb-61ae-4e01-90fa-0895e8df20daNestor, P. (Peter)|||/items/c7fc0d7d-990e-4862-b80c-af214d8763a1Nobili, F. (Flavio)|||/items/d76e964c-ceed-4618-b930-181adc632633Walker, Z. (Zuzana)|||/items/edc5f5df-6c18-4772-86f8-ed0c06945e3dMorbelli, S. (Silvia)|||/items/2e675f85-ba83-455c-8269-b90e1ee382d4Boccardi, M. (Marina)|||/items/bd4c6f64-dbed-47c1-a5f6-2f953683e348Arbizu, J. (Javier)|||/items/41665d76-74c1-4652-acb9-a98cba4ddd0bFDG-PETPrimary progressive aphasiaPPANeurodegenerativeSemanticLogopenicAgrammaticDementiaPurpose A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA). Methods Seven panelists were appointed by the EANM and EAN and a literature search was performed by using harmonized PICO (Population, Intervention, Comparison, Outcome) question keywords. The studies were screened for eligibility, and data extracted to assess their methodological quality. Critical outcomes were accuracy indices in differentiating different PPA clinical forms. Subsequently Delphi rounds were held with the extracted data and quality assessment to reach a consensus based on both literature and expert opinion. Results Critical outcomes for this PICO were available in four of the examined papers. The level of formal evidence supporting clinical utility of FDG-PET in differentiating among PPA variants was considered as poor. However, the consensual recommendation was defined on Delphi round I, with six out of seven panelists supporting clinical use. Conclusions Quantitative evidence demonstrating utility or lack thereof is still missing. Panelists decided consistently to provide interim support for clinical use based on the fact that a typical atrophy or metabolic pattern is needed for PPA according to the diagnostic criteria, and the synaptic failure detected by FDG-PET is an earlier phenomenon than atrophy. Also, a normal FDGPET points to a non-neurodegenerative cause.SpringerDadun. Depósito Académico Digital Universidad de Navarra20232023-04-0520182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/65871reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/658712026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| title |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| spellingShingle |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia Bouwman, F. (Femke)|||/items/9d0a94af-dd86-4441-80ac-fa599a87bd88 FDG-PET Primary progressive aphasia PPA Neurodegenerative Semantic Logopenic Agrammatic Dementia |
| title_short |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| title_full |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| title_fullStr |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| title_full_unstemmed |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| title_sort |
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia |
| dc.creator.none.fl_str_mv |
Bouwman, F. (Femke)|||/items/9d0a94af-dd86-4441-80ac-fa599a87bd88 Orini, S. (Stefania)|||/items/66ab2a2b-6379-4096-b2be-cce227a0c90a Gandolfo, F. (Federica)|||/items/0278f7e0-fb9c-4ff2-bbbc-060cbff029b7 Altomare, D. (Daniele)|||/items/fec9e5e8-6437-4fc5-a71b-29b544b54c78 Festari, C. (Cristina)|||/items/1560adcc-2199-42d4-a748-317862cc4260 Agosta, F. (Federica)|||/items/6f2f430b-eba8-41e3-9942-67cbe06b03ee Drzezga, A. (Alexander)|||/items/a72faedb-61ae-4e01-90fa-0895e8df20da Nestor, P. (Peter)|||/items/c7fc0d7d-990e-4862-b80c-af214d8763a1 Nobili, F. (Flavio)|||/items/d76e964c-ceed-4618-b930-181adc632633 Walker, Z. (Zuzana)|||/items/edc5f5df-6c18-4772-86f8-ed0c06945e3d Morbelli, S. (Silvia)|||/items/2e675f85-ba83-455c-8269-b90e1ee382d4 Boccardi, M. (Marina)|||/items/bd4c6f64-dbed-47c1-a5f6-2f953683e348 Arbizu, J. (Javier)|||/items/41665d76-74c1-4652-acb9-a98cba4ddd0b |
| author |
Bouwman, F. (Femke)|||/items/9d0a94af-dd86-4441-80ac-fa599a87bd88 |
| author_facet |
Bouwman, F. (Femke)|||/items/9d0a94af-dd86-4441-80ac-fa599a87bd88 Orini, S. (Stefania)|||/items/66ab2a2b-6379-4096-b2be-cce227a0c90a Gandolfo, F. (Federica)|||/items/0278f7e0-fb9c-4ff2-bbbc-060cbff029b7 Altomare, D. (Daniele)|||/items/fec9e5e8-6437-4fc5-a71b-29b544b54c78 Festari, C. (Cristina)|||/items/1560adcc-2199-42d4-a748-317862cc4260 Agosta, F. (Federica)|||/items/6f2f430b-eba8-41e3-9942-67cbe06b03ee Drzezga, A. (Alexander)|||/items/a72faedb-61ae-4e01-90fa-0895e8df20da Nestor, P. (Peter)|||/items/c7fc0d7d-990e-4862-b80c-af214d8763a1 Nobili, F. (Flavio)|||/items/d76e964c-ceed-4618-b930-181adc632633 Walker, Z. (Zuzana)|||/items/edc5f5df-6c18-4772-86f8-ed0c06945e3d Morbelli, S. (Silvia)|||/items/2e675f85-ba83-455c-8269-b90e1ee382d4 Boccardi, M. (Marina)|||/items/bd4c6f64-dbed-47c1-a5f6-2f953683e348 Arbizu, J. (Javier)|||/items/41665d76-74c1-4652-acb9-a98cba4ddd0b |
| author_role |
author |
| author2 |
Orini, S. (Stefania)|||/items/66ab2a2b-6379-4096-b2be-cce227a0c90a Gandolfo, F. (Federica)|||/items/0278f7e0-fb9c-4ff2-bbbc-060cbff029b7 Altomare, D. (Daniele)|||/items/fec9e5e8-6437-4fc5-a71b-29b544b54c78 Festari, C. (Cristina)|||/items/1560adcc-2199-42d4-a748-317862cc4260 Agosta, F. (Federica)|||/items/6f2f430b-eba8-41e3-9942-67cbe06b03ee Drzezga, A. (Alexander)|||/items/a72faedb-61ae-4e01-90fa-0895e8df20da Nestor, P. (Peter)|||/items/c7fc0d7d-990e-4862-b80c-af214d8763a1 Nobili, F. (Flavio)|||/items/d76e964c-ceed-4618-b930-181adc632633 Walker, Z. (Zuzana)|||/items/edc5f5df-6c18-4772-86f8-ed0c06945e3d Morbelli, S. (Silvia)|||/items/2e675f85-ba83-455c-8269-b90e1ee382d4 Boccardi, M. (Marina)|||/items/bd4c6f64-dbed-47c1-a5f6-2f953683e348 Arbizu, J. (Javier)|||/items/41665d76-74c1-4652-acb9-a98cba4ddd0b |
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author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
FDG-PET Primary progressive aphasia PPA Neurodegenerative Semantic Logopenic Agrammatic Dementia |
| topic |
FDG-PET Primary progressive aphasia PPA Neurodegenerative Semantic Logopenic Agrammatic Dementia |
| description |
Purpose A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA). Methods Seven panelists were appointed by the EANM and EAN and a literature search was performed by using harmonized PICO (Population, Intervention, Comparison, Outcome) question keywords. The studies were screened for eligibility, and data extracted to assess their methodological quality. Critical outcomes were accuracy indices in differentiating different PPA clinical forms. Subsequently Delphi rounds were held with the extracted data and quality assessment to reach a consensus based on both literature and expert opinion. Results Critical outcomes for this PICO were available in four of the examined papers. The level of formal evidence supporting clinical utility of FDG-PET in differentiating among PPA variants was considered as poor. However, the consensual recommendation was defined on Delphi round I, with six out of seven panelists supporting clinical use. Conclusions Quantitative evidence demonstrating utility or lack thereof is still missing. Panelists decided consistently to provide interim support for clinical use based on the fact that a typical atrophy or metabolic pattern is needed for PPA according to the diagnostic criteria, and the synaptic failure detected by FDG-PET is an earlier phenomenon than atrophy. Also, a normal FDGPET points to a non-neurodegenerative cause. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01 2018 2018-01-01 2023 2023-04-05 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/65871 |
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https://hdl.handle.net/10171/65871 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Springer |
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Springer |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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