Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors

Therapeutic perspectives of bone tumors such as osteosarcom are main restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancers qualene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was sy...

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Autores: Rodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370bae, Sebastian, V. (Víctor)|||/items/42de1b00-b9b3-4844-830d-2c795578a861, Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40, Couvreur, P. (Patrick)|||/items/8aad59a7-2394-4ef2-82a5-6c0dd875330e, Desmaële, D. (Didier)|||/items/27ce00ba-c1be-472f-adf6-3c9c90105534
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/63341
Acesso em linha:https://hdl.handle.net/10171/63341
Access Level:acceso abierto
Palavra-chave:Osteosarcome
Antitumor agents
Nanoparticles
Hydroxyapatite
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spelling Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumorsRodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370baeSebastian, V. (Víctor)|||/items/42de1b00-b9b3-4844-830d-2c795578a861Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40Couvreur, P. (Patrick)|||/items/8aad59a7-2394-4ef2-82a5-6c0dd875330eDesmaële, D. (Didier)|||/items/27ce00ba-c1be-472f-adf6-3c9c90105534OsteosarcomeAntitumor agentsNanoparticlesHydroxyapatiteTherapeutic perspectives of bone tumors such as osteosarcom are main restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancers qualene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bi-sphosphonatemoiety to the squalenechain. This amphiphilic compound was inserted onto squalenoyl-gemcitabinenano-particles using the nanoprecipitation method. The co-assemblyled to nanoconstructsof 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite,a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pedia tricoste osarcomacells. Furtherin vivo studies will shed lighton the potential of these nano medicines for the treatment of bones arcomas.WileyDadun. Depósito Académico Digital Universidad de Navarra20222022-04-0520212021-12-1420212021-12-14journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63341reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/633412026-06-21T12:47:57Z
dc.title.none.fl_str_mv Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
title Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
spellingShingle Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
Rodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370bae
Osteosarcome
Antitumor agents
Nanoparticles
Hydroxyapatite
title_short Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
title_full Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
title_fullStr Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
title_full_unstemmed Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
title_sort Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors
dc.creator.none.fl_str_mv Rodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370bae
Sebastian, V. (Víctor)|||/items/42de1b00-b9b3-4844-830d-2c795578a861
Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40
Couvreur, P. (Patrick)|||/items/8aad59a7-2394-4ef2-82a5-6c0dd875330e
Desmaële, D. (Didier)|||/items/27ce00ba-c1be-472f-adf6-3c9c90105534
author Rodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370bae
author_facet Rodriguez-Nogales, C. (Carlos)|||/items/b659e92f-09dc-43d9-9577-26624a370bae
Sebastian, V. (Víctor)|||/items/42de1b00-b9b3-4844-830d-2c795578a861
Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40
Couvreur, P. (Patrick)|||/items/8aad59a7-2394-4ef2-82a5-6c0dd875330e
Desmaële, D. (Didier)|||/items/27ce00ba-c1be-472f-adf6-3c9c90105534
author_role author
author2 Sebastian, V. (Víctor)|||/items/42de1b00-b9b3-4844-830d-2c795578a861
Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40
Couvreur, P. (Patrick)|||/items/8aad59a7-2394-4ef2-82a5-6c0dd875330e
Desmaële, D. (Didier)|||/items/27ce00ba-c1be-472f-adf6-3c9c90105534
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Osteosarcome
Antitumor agents
Nanoparticles
Hydroxyapatite
topic Osteosarcome
Antitumor agents
Nanoparticles
Hydroxyapatite
description Therapeutic perspectives of bone tumors such as osteosarcom are main restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancers qualene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bi-sphosphonatemoiety to the squalenechain. This amphiphilic compound was inserted onto squalenoyl-gemcitabinenano-particles using the nanoprecipitation method. The co-assemblyled to nanoconstructsof 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite,a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pedia tricoste osarcomacells. Furtherin vivo studies will shed lighton the potential of these nano medicines for the treatment of bones arcomas.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-14
2021
2021-12-14
2022
2022-04-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/63341
url https://hdl.handle.net/10171/63341
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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