Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor
A label-free interferometric transducer showing a theoretical detection limit for homogeneous sensing of 5 × 10⁻⁸ RIU, being equivalent to a protein mass coverage resolution of 2.8 fg mm⁻², is used to develop a high sensitive biosensor for protein detection. The extreme sensitivity of this transduce...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:195672 |
| Acceso en línea: | https://ddd.uab.cat/record/195672 https://dx.doi.org/urn:doi:10.1002/jbio.201600154 |
| Access Level: | acceso abierto |
| Palabra clave: | BiMW interferometer Silicon nanowaveguides Label-free biosensing Hgh detection Pg/ml detection range |
| Sumario: | A label-free interferometric transducer showing a theoretical detection limit for homogeneous sensing of 5 × 10⁻⁸ RIU, being equivalent to a protein mass coverage resolution of 2.8 fg mm⁻², is used to develop a high sensitive biosensor for protein detection. The extreme sensitivity of this transducer combined with a selective bioreceptor layer enables the direct evaluation of the human growth hormone (hGH) in undiluted urine matrix in the 10 pg mL⁻¹ range. (Figure presented.). |
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