MHC class I diversity in chimpanzees and bonobos

Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evol...

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Autores: Maibach, Vincent, Hans, Jörg B., Hvilsom, Christina, Marquès i Bonet, Tomàs, 1975-, Vigilant, Linda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/33346
Acceso en línea:http://hdl.handle.net/10230/33346
http://dx.doi.org/10.1007/s00251-017-0990-x
Access Level:acceso abierto
Palabra clave:Pan troglodytes
Pan paniscus
PacBio
Great apes
Next-generation sequencing
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spelling MHC class I diversity in chimpanzees and bonobosMaibach, VincentHans, Jörg B.Hvilsom, ChristinaMarquès i Bonet, Tomàs, 1975-Vigilant, LindaPan troglodytesPan paniscusPacBioGreat apesNext-generation sequencingMajor histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evolutionary relatives of humans and last shared a common ancestor some 1 mya. However, little is known concerning MHC class I diversity in bonobos or in central chimpanzees, the most numerous and genetically diverse chimpanzee subspecies. Here, we used a long-read sequencing technology (PacBio) to sequence the classical MHC class I genes A, B, C, and A-like in 20 and 30 wild-born bonobos and chimpanzees, respectively, with a main focus on central chimpanzees to assess and compare diversity in those two species. We describe in total 21 and 42 novel coding region sequences for the two species, respectively. In addition, we found evidence for a reduced MHC class I diversity in bonobos as compared to central chimpanzees as well as to western chimpanzees and humans. The reduced bonobo MHC class I diversity may be the result of a selective process in their evolutionary past since their split from chimpanzees.Springer201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33346http://dx.doi.org/10.1007/s00251-017-0990-xreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésImmunogenetics. 2017;69(10):661-76© The Author(s) 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/333462026-05-29T05:05:01Z
dc.title.none.fl_str_mv MHC class I diversity in chimpanzees and bonobos
title MHC class I diversity in chimpanzees and bonobos
spellingShingle MHC class I diversity in chimpanzees and bonobos
Maibach, Vincent
Pan troglodytes
Pan paniscus
PacBio
Great apes
Next-generation sequencing
title_short MHC class I diversity in chimpanzees and bonobos
title_full MHC class I diversity in chimpanzees and bonobos
title_fullStr MHC class I diversity in chimpanzees and bonobos
title_full_unstemmed MHC class I diversity in chimpanzees and bonobos
title_sort MHC class I diversity in chimpanzees and bonobos
dc.creator.none.fl_str_mv Maibach, Vincent
Hans, Jörg B.
Hvilsom, Christina
Marquès i Bonet, Tomàs, 1975-
Vigilant, Linda
author Maibach, Vincent
author_facet Maibach, Vincent
Hans, Jörg B.
Hvilsom, Christina
Marquès i Bonet, Tomàs, 1975-
Vigilant, Linda
author_role author
author2 Hans, Jörg B.
Hvilsom, Christina
Marquès i Bonet, Tomàs, 1975-
Vigilant, Linda
author2_role author
author
author
author
dc.subject.none.fl_str_mv Pan troglodytes
Pan paniscus
PacBio
Great apes
Next-generation sequencing
topic Pan troglodytes
Pan paniscus
PacBio
Great apes
Next-generation sequencing
description Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evolutionary relatives of humans and last shared a common ancestor some 1 mya. However, little is known concerning MHC class I diversity in bonobos or in central chimpanzees, the most numerous and genetically diverse chimpanzee subspecies. Here, we used a long-read sequencing technology (PacBio) to sequence the classical MHC class I genes A, B, C, and A-like in 20 and 30 wild-born bonobos and chimpanzees, respectively, with a main focus on central chimpanzees to assess and compare diversity in those two species. We describe in total 21 and 42 novel coding region sequences for the two species, respectively. In addition, we found evidence for a reduced MHC class I diversity in bonobos as compared to central chimpanzees as well as to western chimpanzees and humans. The reduced bonobo MHC class I diversity may be the result of a selective process in their evolutionary past since their split from chimpanzees.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33346
http://dx.doi.org/10.1007/s00251-017-0990-x
url http://hdl.handle.net/10230/33346
http://dx.doi.org/10.1007/s00251-017-0990-x
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Immunogenetics. 2017;69(10):661-76
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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