Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam

We report an outbreak of KPC-producing Pseudomonas aeruginosa in Spain, involving four patients and an environmental isolate recovered from a hospital sink. All isolates belonged to clone ST253 and exhibited difficult-to-treat resistance, including resistance to imipenem/relebactam and meropenem/vab...

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Bibliographic Details
Authors: Pérez-Rodríguez, Gloria, Aja-Macaya, Pablo, González-Pinto, Lucía, Taltavull, Biel, Tarriño-León, María, Gallardo-García, María del Mar, Blanco-Martín, Tania, Rodríguez-Pallares, Salud, Sánchez-Peña, Lucía, Moscoso, Miriam, Beceiro, Alejandro, Oliver, Antonio, Bou, Germán, Arca-Suárez, Jorge
Format: article
Publication Date:2026
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:dnet:docusalut___::8a27e4da9cd6e91bc52bab090a57745d
Online Access:https://hdl.handle.net/20.500.13003/27139
Access Level:Open access
Keyword:KPC
Pseudomonas aeruginosa
carbapenem
carbapenemase
imipenem/relebactam
meropenem/vaborbactam
mutational mechanisms
β-lactam resistance
β-lactamase
β-lactamase inhibitor
Description
Summary:We report an outbreak of KPC-producing Pseudomonas aeruginosa in Spain, involving four patients and an environmental isolate recovered from a hospital sink. All isolates belonged to clone ST253 and exhibited difficult-to-treat resistance, including resistance to imipenem/relebactam and meropenem/vaborbactam. Genomic analysis confirmed a plasmid-encoded bla KPC-2 and OprD deficiency. Functional assays demonstrated synergy between KPC-2 production and porin loss on resistance to carbapenem/β-lactamase inhibitors. The findings highlight the clinical threat posed by KPC-producing P. aeruginosa .

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