Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis

Rinitis al·lèrgica; Infants i adolescents; Tirosina microcristal·lina

Detalles Bibliográficos
Autores: Almeida-Sánchez, Zulay M., García-Núñez, Ignacio, Laín, Sofia, Martínez-Tadeo, Juan A., Martos, Maria D., Sala Cunill, Anna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7318
Acceso en línea:https://hdl.handle.net/11351/7318
http://hdl.handle.net/11351/7318
Access Level:acceso abierto
Palabra clave:Àcars
Immunosupressió
Rinitis - Tractament
DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic
Other subheadings::Other subheadings::/therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, Immunologic
ORGANISMS::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites
ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica
Otros calificadores::Otros calificadores::/terapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunosupresión::desensibilización inmunológica
ORGANISMOS::Eukaryota::animales::invertebrados::artrópodos::Arachnida::ácaros y garrapatas::ácaros
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
title Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
spellingShingle Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
Almeida-Sánchez, Zulay M.
Àcars
Immunosupressió
Rinitis - Tractament
DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic
Other subheadings::Other subheadings::/therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, Immunologic
ORGANISMS::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites
ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica
Otros calificadores::Otros calificadores::/terapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunosupresión::desensibilización inmunológica
ORGANISMOS::Eukaryota::animales::invertebrados::artrópodos::Arachnida::ácaros y garrapatas::ácaros
title_short Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
title_full Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
title_fullStr Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
title_full_unstemmed Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
title_sort Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis
dc.creator.none.fl_str_mv Almeida-Sánchez, Zulay M.
García-Núñez, Ignacio
Laín, Sofia
Martínez-Tadeo, Juan A.
Martos, Maria D.
Sala Cunill, Anna
author Almeida-Sánchez, Zulay M.
author_facet Almeida-Sánchez, Zulay M.
García-Núñez, Ignacio
Laín, Sofia
Martínez-Tadeo, Juan A.
Martos, Maria D.
Sala Cunill, Anna
author_role author
author2 García-Núñez, Ignacio
Laín, Sofia
Martínez-Tadeo, Juan A.
Martos, Maria D.
Sala Cunill, Anna
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Sala-Cunill A] Secció d’Al·lèrgia, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Almeida-Sánchez ZM] Hospital General de la Palma, La Palma, Spain. [García-Núñez I] Pneumokal Research Institute, S.L. Estepona, Málaga, Spain. Allergology and Pneumology Department, Hospital Quirónsalud Campo de Gibraltar, Cádiz, Spain. [Laín S] Hospital General de Catalunya, Sant Cugat del Vallès, Spain. [Martínez-Tadeo JA] Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. [Martos MD] Hospital de Torrevieja, Alicante, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Àcars
Immunosupressió
Rinitis - Tractament
DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic
Other subheadings::Other subheadings::/therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, Immunologic
ORGANISMS::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites
ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica
Otros calificadores::Otros calificadores::/terapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunosupresión::desensibilización inmunológica
ORGANISMOS::Eukaryota::animales::invertebrados::artrópodos::Arachnida::ácaros y garrapatas::ácaros
topic Àcars
Immunosupressió
Rinitis - Tractament
DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic
Other subheadings::Other subheadings::/therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, Immunologic
ORGANISMS::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites
ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica
Otros calificadores::Otros calificadores::/terapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunosupresión::desensibilización inmunológica
ORGANISMOS::Eukaryota::animales::invertebrados::artrópodos::Arachnida::ácaros y garrapatas::ácaros
description Rinitis al·lèrgica; Infants i adolescents; Tirosina microcristal·lina
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7318
http://hdl.handle.net/11351/7318
url https://hdl.handle.net/11351/7318
http://hdl.handle.net/11351/7318
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Allergologia et immunopathologia;49(4)
https://doi.org/10.15586/aei.v49i4.195
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CODON Publications
publisher.none.fl_str_mv CODON Publications
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418868718436352
spelling Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic RhinitisAlmeida-Sánchez, Zulay M.García-Núñez, IgnacioLaín, SofiaMartínez-Tadeo, Juan A.Martos, Maria D.Sala Cunill, AnnaÀcarsImmunosupressióRinitis - TractamentDISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, AllergicOther subheadings::Other subheadings::/therapyANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, ImmunologicORGANISMS::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::MitesENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgicaOtros calificadores::Otros calificadores::/terapiaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunosupresión::desensibilización inmunológicaORGANISMOS::Eukaryota::animales::invertebrados::artrópodos::Arachnida::ácaros y garrapatas::ácarosRinitis al·lèrgica; Infants i adolescents; Tirosina microcristal·linaRinitis alérgica; Niños y adolescentes; Tirosina microcristalinaAllerghic rhinitis; Children and adolescents; Microcrystalline tyrosineEvidence regarding allergen immunotherapy (AIT) in pediatric population is scarce. We have assessed safety and effectiveness of subcutaneous AIT with a microcrystalline tyrosine (MCT)-associated mite allergoid, Acarovac Plus®, in children and adolescents with allergic rhinitis (AR), with and without asthma, in the real-world setting. This was a retrospective, multicenter study including children and adolescents aged 5 years to 17 years with AR, with and without asthma, and sensitized to mites, receiving AIT with Acarovac Plus® during ≥6 months. Primary and secondary objectives were safety and effectiveness, respectively. Effectiveness variables were assessed during 12 months before and after AIT and included unscheduled visits to the healthcare center and emergency room admissions, rhinitis and asthma symptoms according to ARIA and GEMA classifications, respectively, medication use, and patients’ and physicians’ disease perception graded on a visual analog scale (VAS). All 79 patients included had a mean (SD) age of 12.7 (3.3) years. Two patients experienced systemic adverse reactions (none severe). Unscheduled visits to the healthcare center and emergency room admissions decreased (mean (SD) 3.02 [2.48] and 0.63 [1.35] vs. 1.08 [1.38] and 0.09 [0.38], before and after treatment, p < 0.001 and p = 0.001, respectively). After AIT, rhinitis and asthma classification changed (p < 0.0001 for all classifications), showing improvements in symptoms and a significant decrease in rhinitis and use of medication for asthma and VAS scores grading patients’ and physicians’ disease perception (p < 0.001). In conclusion, these results show that AIT with an MCT-associated mite allergoid appears safe and effective in children and adolescents with AR treated in the real-world setting.This study was supported by Allergy Therapeutics Ibérica.CODON PublicationsInstitut Català de la Salut[Sala-Cunill A] Secció d’Al·lèrgia, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Almeida-Sánchez ZM] Hospital General de la Palma, La Palma, Spain. [García-Núñez I] Pneumokal Research Institute, S.L. Estepona, Málaga, Spain. Allergology and Pneumology Department, Hospital Quirónsalud Campo de Gibraltar, Cádiz, Spain. [Laín S] Hospital General de Catalunya, Sant Cugat del Vallès, Spain. [Martínez-Tadeo JA] Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. [Martos MD] Hospital de Torrevieja, Alicante, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7318http://hdl.handle.net/11351/7318Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAllergologia et immunopathologia;49(4)https://doi.org/10.15586/aei.v49i4.195Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/73182026-05-29T05:05:01Z
score 15.812429

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