Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis

[EN] Plants coordinate their growth and development with the environment through integration of circadian clock and photosensory pathways. In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHR...

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Autores: Martín, G., Rovira, A., Veciana, N., Soy, J., Toledo, G., Gommers, C., Boix, M., Henriques, R., Minguet, E.G., Halliday, K., Leivar, P., Monte, E., ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/146886
Acceso en línea:https://riunet.upv.es/handle/10251/146886
Access Level:acceso abierto
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
title Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
spellingShingle Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
Martín, G.
title_short Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
title_full Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
title_fullStr Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
title_full_unstemmed Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
title_sort Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in Arabidopsis
dc.creator.none.fl_str_mv Martín, G.
Rovira, A.
Veciana, N.
Soy, J.
Toledo, G.
Gommers, C.
Boix, M.
Henriques, R.
Minguet, E.G.
Halliday, K.
Leivar, P.
Monte, E.
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
author Martín, G.
author_facet Martín, G.
Rovira, A.
Veciana, N.
Soy, J.
Toledo, G.
Gommers, C.
Boix, M.
Henriques, R.
Minguet, E.G.
Halliday, K.
Leivar, P.
Monte, E.
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
author_role author
author2 Rovira, A.
Veciana, N.
Soy, J.
Toledo, G.
Gommers, C.
Boix, M.
Henriques, R.
Minguet, E.G.
Halliday, K.
Leivar, P.
Monte, E.
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto Universitario Mixto de Biología Molecular y Celular de Plantas
Royal Society, Reino Unido
Generalitat de Catalunya
Ministerio de Economía y Competitividad
Ministerio de Ciencia e Innovación
Repositorio Institucional de la Universitat Politècnica de València Riunet
description [EN] Plants coordinate their growth and development with the environment through integration of circadian clock and photosensory pathways. In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHROME-INTERACTING FACTORS (PIFs) directly inducing expression of growth-related genes [1-6]. PIFs accumulate progressively during the night and are targeted for degradation by active phytochromes in the light, when growth is reduced. Although PIF proteins are also detected during the day hours [7-10], their growth-promoting activity is inhibited through unknown mechanisms. Recently, the core clock components and transcriptional repressors PSEUDO-RESPONSE REGULATORS PRR9/7/5 [11, 12], negative regulators of hypocotyl elongation [13, 14], were described to associate to G boxes [15], the DNA motifs recognized by the PIFs [16, 17], suggesting that PRR and PIF function might converge antagonistically to regulate growth. Here we report that PRR9/7/5 and PIFs physically interact and bind to the same promoter region of pre-dawn-phased, growth-related genes, and we identify the transcription factor CDF5 [18, 19] as target of this interplay. In SD, CDF5 expression is sequentially repressed from morning to dusk by PRRs and induced pre-dawn by PIFs. Consequently, CDF5 accumulates specifically at dawn, when it induces cell elongation. Our findings provide a framework for recent TIMING OF CAB EXPRESSION 1 (TOC1/PRR1) data [5, 20] and reveal that the long described circadian morning-to-midnight waves of the PRR transcriptional repressors (PRR9, PRR7, PRR5, and TOC1) [21] jointly gate PIF activity to dawn to prevent overgrowth through sequential regulation of common PIF-PRR target genes such as CDF5.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/146886
url https://riunet.upv.es/handle/10251/146886
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 FP7 256420 Identification and characterization of novel plant growth regulators acting downstream of the phytochrome-interacting bHLH transcription factors in the dark
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 SEV-2015-0533 AGR-CONSORCI CSIC-IRTA-UAB CENTRE DE RECERCA EN AGRIGENOMICA (CRAG)
European Commission https://doi.org/10.13039/501100000780 FP7 334052 Integrating cell growth and cell division with light signals and circadian clock function – the role of Arabidopsis S6 kinase in the regulation of the diurnal pattern of growth
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2012-31672 REGULACION DEL CRECIMIENTO Y DESARROLLO VEGETAL EN OSCURIDAD MEDIADA POR EL FACTOR DE TRANSCRIPCION PIF3 (PHYTOCHROME-INTERACTING FACTOR 3)
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2015-68460-P COMUNICACION INTERORGANELO EN LA REGULACION POR LUZ DEL DESARROLLO DE LAS PLANTAS
Generalitat de Catalunya Generalitat de Catalunya 2014 SGR 1406
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2015-70812-ERC Y SIN EMBARGO OSCILAN: ANALISIS FUNCIONAL DE LOS ARNS LARGOS NO-CODIFICANTES REGULADOS POR EL RELOJ CIRCADIANO
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 RYC-2011-09220 RYC-2011-09220
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2014-57200-JIN MEJORA DE LA PRODUCTIVIDAD DE LOS CULTIVOS AGRICOLAS EN CONDICIONES DE ESTRES POR ALTAS TEMPERATURAS
Royal Society Royal Society RG2016R1
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2013-43184-P PAPEL DE LA PREFOLDINA EN EL NUCLEO DEPENDIENTE DE DELLAS EN ARABIDOPSIS.
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - Sin obra derivada (by-nd)
http://creativecommons.org/licenses/by-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - Sin obra derivada (by-nd)
http://creativecommons.org/licenses/by-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Circadian waves of transcriptional repression shape PIF-regulated photoperiod-responsive growth in ArabidopsisMartín, G.Rovira, A.Veciana, N.Soy, J.Toledo, G.Gommers, C.Boix, M.Henriques, R.Minguet, E.G.Halliday, K.Leivar, P.Monte, E.ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713[EN] Plants coordinate their growth and development with the environment through integration of circadian clock and photosensory pathways. In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHROME-INTERACTING FACTORS (PIFs) directly inducing expression of growth-related genes [1-6]. PIFs accumulate progressively during the night and are targeted for degradation by active phytochromes in the light, when growth is reduced. Although PIF proteins are also detected during the day hours [7-10], their growth-promoting activity is inhibited through unknown mechanisms. Recently, the core clock components and transcriptional repressors PSEUDO-RESPONSE REGULATORS PRR9/7/5 [11, 12], negative regulators of hypocotyl elongation [13, 14], were described to associate to G boxes [15], the DNA motifs recognized by the PIFs [16, 17], suggesting that PRR and PIF function might converge antagonistically to regulate growth. Here we report that PRR9/7/5 and PIFs physically interact and bind to the same promoter region of pre-dawn-phased, growth-related genes, and we identify the transcription factor CDF5 [18, 19] as target of this interplay. In SD, CDF5 expression is sequentially repressed from morning to dusk by PRRs and induced pre-dawn by PIFs. Consequently, CDF5 accumulates specifically at dawn, when it induces cell elongation. Our findings provide a framework for recent TIMING OF CAB EXPRESSION 1 (TOC1/PRR1) data [5, 20] and reveal that the long described circadian morning-to-midnight waves of the PRR transcriptional repressors (PRR9, PRR7, PRR5, and TOC1) [21] jointly gate PIF activity to dawn to prevent overgrowth through sequential regulation of common PIF-PRR target genes such as CDF5.We thank D. Somers, S. Prat, G. Coupland, and R. McClung for sharing seed and plasmid resources. We thank G. Steele for generating double and triple prr mutants and the prrpif mutant combinations. The work in this manuscript was supported by grants from the Spanish "Ministerio de Economia y Competitividad'' (MINECO) (BIO2012-31672 and BIO2015-68460-P) and the Generalitat de Catalunya (2014-SGR-1406) to E.M.; by Marie Curie IRG grant PIRG06-GA-2009-256420 to P.L.; by the European Commission (PCIG2012-GA-2012-334052) and MINECO (BIO2015-70812-ERC and RYC-2011-09220) to R.H.; by Royal Society grant RG2016R1 to G.T.-O.; by MINECO BIO2013-43184-P to D. A.; and by MINECO AGL2014-57200-JIN to E.G.M. We acknowledge financial support by the CERCA programme/Generalitat de Catalunya and from MINECO through the "Severo Ochoa Programme for Centers of Excellence in R&D'' 2016-2019 (SEV-2015-0533).ElsevierInstituto Universitario Mixto de Biología Molecular y Celular de PlantasRoyal Society, Reino UnidoGeneralitat de CatalunyaMinisterio de Economía y CompetitividadMinisterio de Ciencia e InnovaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20182018-01-22journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/146886reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 FP7 256420 Identification and characterization of novel plant growth regulators acting downstream of the phytochrome-interacting bHLH transcription factors in the darkMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 SEV-2015-0533 AGR-CONSORCI CSIC-IRTA-UAB CENTRE DE RECERCA EN AGRIGENOMICA (CRAG)European Commission https://doi.org/10.13039/501100000780 FP7 334052 Integrating cell growth and cell division with light signals and circadian clock function – the role of Arabidopsis S6 kinase in the regulation of the diurnal pattern of growthMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2012-31672 REGULACION DEL CRECIMIENTO Y DESARROLLO VEGETAL EN OSCURIDAD MEDIADA POR EL FACTOR DE TRANSCRIPCION PIF3 (PHYTOCHROME-INTERACTING FACTOR 3)Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2015-68460-P COMUNICACION INTERORGANELO EN LA REGULACION POR LUZ DEL DESARROLLO DE LAS PLANTASGeneralitat de Catalunya Generalitat de Catalunya 2014 SGR 1406Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2015-70812-ERC Y SIN EMBARGO OSCILAN: ANALISIS FUNCIONAL DE LOS ARNS LARGOS NO-CODIFICANTES REGULADOS POR EL RELOJ CIRCADIANOMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 RYC-2011-09220 RYC-2011-09220Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2014-57200-JIN MEJORA DE LA PRODUCTIVIDAD DE LOS CULTIVOS AGRICOLAS EN CONDICIONES DE ESTRES POR ALTAS TEMPERATURASRoyal Society Royal Society RG2016R1Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2013-43184-P PAPEL DE LA PREFOLDINA EN EL NUCLEO DEPENDIENTE DE DELLAS EN ARABIDOPSIS.open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - Sin obra derivada (by-nd) http://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1468862026-06-13T07:49:27Z
score 15,300719

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