Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study

Vallejo-Casas, J.A. (Juan Antonio)|||/items/663861ec-49dd-4b16-a21f-9d775d2ec84e; Sambo, M. (Marcel)|||/items/f2215404-a074-4696-9b4b-007eb5d92347; López-López, C. (Carlos)|||/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623; Duran-Poveda, M. (Manuel)|||/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3; Rodríguez-Villanueva, J. (Julio)|||/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8; Santos, R.J. (Rita Joana)|||/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5b; Llanos, M. (Marta)|||/items/0729f342-59cf-48f6-bc21-4583b5c56ab4; Navarro-González, E. (Elena)|||/items/2a5ab034-b984-4db0-ac29-01769e51deb4; Aller, J. (Javier)|||/items/ec34b448-a292-40db-b68a-b6b7fc61fa12; Pubul, V. (Virginia)|||/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939; Guadalix, S. (Sonsoles)|||/items/59ca9666-3549-43be-b944-428d56084e83; Crespo, G. (Guillermo)|||/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fd; González, C. (Cintia)|||/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2; Zafón, C. (Carles)|||/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47; Navarro-Martín, M. (Miguel)|||/items/ed497a9b-719a-4fe0-b55b-236687bb5e30; Santamaría-Sandi, J. (Javier)|||/items/527249b4-f47d-47c5-bd13-d511b652edfc; Segura, Á. (Ángel)|||/items/67810931-6248-45e9-b582-3ca8a66c880e; Gajate, P. (Pablo)|||/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3c; Gómez-Balaguer, M. (Marcelino)|||/items/db41edd7-1409-4046-b379-b421c7839085; Valdivia, J. (Javier)|||/items/358fe79c-372e-4629-9bc5-e25d618fa8b3; Puig-Domingo, M. (Manel)|||/items/f5586785-d135-4265-b112-e266c12674ad; Galofre-Ferrater, J.C. (Juan Carlos)|||/items/e7463ff9-97f4-4119-a307-fd978c0017fd; Castelo, B. (Beatriz)|||/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43; Villanueva, M.J. (María José)|||/items/338926bd-47cc-4a27-a30a-53c3a05e0538; Argüelles, I. (Iñaki)|||/items/e398fe20-18b4-48ba-9d80-359c4437c374; Orcajo-Rincón, L. (Lorenzo)|||/items/cc08276f-fa02-4a05-997f-3fcc00a578e6

Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study

Background: Up to 30% of differentiated thyroid cancer (DTC) will develop advanced-stage disease (aDTC) with reduced overall survival (OS). Objective: The aim of this study is to characterize initial diagnosis of aDTC, its therapeutic management, and prognosis in Spain and Portugal. Methods: A multi...

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Autores:	Vallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84e, Sambo, M. (Marcel)\|\|\|/items/f2215404-a074-4696-9b4b-007eb5d92347, López-López, C. (Carlos)\|\|\|/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623, Duran-Poveda, M. (Manuel)\|\|\|/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3, Rodríguez-Villanueva, J. (Julio)\|\|\|/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8, Santos, R.J. (Rita Joana)\|\|\|/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5b, Llanos, M. (Marta)\|\|\|/items/0729f342-59cf-48f6-bc21-4583b5c56ab4, Navarro-González, E. (Elena)\|\|\|/items/2a5ab034-b984-4db0-ac29-01769e51deb4, Aller, J. (Javier)\|\|\|/items/ec34b448-a292-40db-b68a-b6b7fc61fa12, Pubul, V. (Virginia)\|\|\|/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939, Guadalix, S. (Sonsoles)\|\|\|/items/59ca9666-3549-43be-b944-428d56084e83, Crespo, G. (Guillermo)\|\|\|/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fd, González, C. (Cintia)\|\|\|/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2, Zafón, C. (Carles)\|\|\|/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47, Navarro-Martín, M. (Miguel)\|\|\|/items/ed497a9b-719a-4fe0-b55b-236687bb5e30, Santamaría-Sandi, J. (Javier)\|\|\|/items/527249b4-f47d-47c5-bd13-d511b652edfc, Segura, Á. (Ángel)\|\|\|/items/67810931-6248-45e9-b582-3ca8a66c880e, Gajate, P. (Pablo)\|\|\|/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3c, Gómez-Balaguer, M. (Marcelino)\|\|\|/items/db41edd7-1409-4046-b379-b421c7839085, Valdivia, J. (Javier)\|\|\|/items/358fe79c-372e-4629-9bc5-e25d618fa8b3, Puig-Domingo, M. (Manel)\|\|\|/items/f5586785-d135-4265-b112-e266c12674ad, Galofre-Ferrater, J.C. (Juan Carlos)\|\|\|/items/e7463ff9-97f4-4119-a307-fd978c0017fd, Castelo, B. (Beatriz)\|\|\|/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43, Villanueva, M.J. (María José)\|\|\|/items/338926bd-47cc-4a27-a30a-53c3a05e0538, Argüelles, I. (Iñaki)\|\|\|/items/e398fe20-18b4-48ba-9d80-359c4437c374, Orcajo-Rincón, L. (Lorenzo)\|\|\|/items/cc08276f-fa02-4a05-997f-3fcc00a578e6
Formato:	artículo
Fecha de publicación:	2022
País:	España
Recursos:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/122399
Acesso em linha:	https://hdl.handle.net/10171/122399
Access Level:	acceso abierto
Palavra-chave:	Advanced differentiated thyroid cancer Epidemiological study Radioiodine-refractory differentiated thyroid cancer Relapsing differentiated thyroid cancer Relapsing prognostic factors Survival prognostic factors

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oai_identifier_str	oai:dadun.unav.edu:10171/122399
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
title	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
spellingShingle	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study Vallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84e Advanced differentiated thyroid cancer Epidemiological study Radioiodine-refractory differentiated thyroid cancer Relapsing differentiated thyroid cancer Relapsing prognostic factors Survival prognostic factors
title_short	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
title_full	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
title_fullStr	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
title_full_unstemmed	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
title_sort	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
dc.creator.none.fl_str_mv	Vallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84e Sambo, M. (Marcel)\|\|\|/items/f2215404-a074-4696-9b4b-007eb5d92347 López-López, C. (Carlos)\|\|\|/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623 Duran-Poveda, M. (Manuel)\|\|\|/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3 Rodríguez-Villanueva, J. (Julio)\|\|\|/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8 Santos, R.J. (Rita Joana)\|\|\|/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5b Llanos, M. (Marta)\|\|\|/items/0729f342-59cf-48f6-bc21-4583b5c56ab4 Navarro-González, E. (Elena)\|\|\|/items/2a5ab034-b984-4db0-ac29-01769e51deb4 Aller, J. (Javier)\|\|\|/items/ec34b448-a292-40db-b68a-b6b7fc61fa12 Pubul, V. (Virginia)\|\|\|/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939 Guadalix, S. (Sonsoles)\|\|\|/items/59ca9666-3549-43be-b944-428d56084e83 Crespo, G. (Guillermo)\|\|\|/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fd González, C. (Cintia)\|\|\|/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2 Zafón, C. (Carles)\|\|\|/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47 Navarro-Martín, M. (Miguel)\|\|\|/items/ed497a9b-719a-4fe0-b55b-236687bb5e30 Santamaría-Sandi, J. (Javier)\|\|\|/items/527249b4-f47d-47c5-bd13-d511b652edfc Segura, Á. (Ángel)\|\|\|/items/67810931-6248-45e9-b582-3ca8a66c880e Gajate, P. (Pablo)\|\|\|/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3c Gómez-Balaguer, M. (Marcelino)\|\|\|/items/db41edd7-1409-4046-b379-b421c7839085 Valdivia, J. (Javier)\|\|\|/items/358fe79c-372e-4629-9bc5-e25d618fa8b3 Puig-Domingo, M. (Manel)\|\|\|/items/f5586785-d135-4265-b112-e266c12674ad Galofre-Ferrater, J.C. (Juan Carlos)\|\|\|/items/e7463ff9-97f4-4119-a307-fd978c0017fd Castelo, B. (Beatriz)\|\|\|/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43 Villanueva, M.J. (María José)\|\|\|/items/338926bd-47cc-4a27-a30a-53c3a05e0538 Argüelles, I. (Iñaki)\|\|\|/items/e398fe20-18b4-48ba-9d80-359c4437c374 Orcajo-Rincón, L. (Lorenzo)\|\|\|/items/cc08276f-fa02-4a05-997f-3fcc00a578e6
author	Vallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84e
author_facet	Vallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84e Sambo, M. (Marcel)\|\|\|/items/f2215404-a074-4696-9b4b-007eb5d92347 López-López, C. (Carlos)\|\|\|/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623 Duran-Poveda, M. (Manuel)\|\|\|/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3 Rodríguez-Villanueva, J. (Julio)\|\|\|/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8 Santos, R.J. (Rita Joana)\|\|\|/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5b Llanos, M. (Marta)\|\|\|/items/0729f342-59cf-48f6-bc21-4583b5c56ab4 Navarro-González, E. (Elena)\|\|\|/items/2a5ab034-b984-4db0-ac29-01769e51deb4 Aller, J. (Javier)\|\|\|/items/ec34b448-a292-40db-b68a-b6b7fc61fa12 Pubul, V. (Virginia)\|\|\|/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939 Guadalix, S. (Sonsoles)\|\|\|/items/59ca9666-3549-43be-b944-428d56084e83 Crespo, G. (Guillermo)\|\|\|/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fd González, C. (Cintia)\|\|\|/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2 Zafón, C. (Carles)\|\|\|/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47 Navarro-Martín, M. (Miguel)\|\|\|/items/ed497a9b-719a-4fe0-b55b-236687bb5e30 Santamaría-Sandi, J. (Javier)\|\|\|/items/527249b4-f47d-47c5-bd13-d511b652edfc Segura, Á. (Ángel)\|\|\|/items/67810931-6248-45e9-b582-3ca8a66c880e Gajate, P. (Pablo)\|\|\|/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3c Gómez-Balaguer, M. (Marcelino)\|\|\|/items/db41edd7-1409-4046-b379-b421c7839085 Valdivia, J. (Javier)\|\|\|/items/358fe79c-372e-4629-9bc5-e25d618fa8b3 Puig-Domingo, M. (Manel)\|\|\|/items/f5586785-d135-4265-b112-e266c12674ad Galofre-Ferrater, J.C. (Juan Carlos)\|\|\|/items/e7463ff9-97f4-4119-a307-fd978c0017fd Castelo, B. (Beatriz)\|\|\|/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43 Villanueva, M.J. (María José)\|\|\|/items/338926bd-47cc-4a27-a30a-53c3a05e0538 Argüelles, I. (Iñaki)\|\|\|/items/e398fe20-18b4-48ba-9d80-359c4437c374 Orcajo-Rincón, L. (Lorenzo)\|\|\|/items/cc08276f-fa02-4a05-997f-3fcc00a578e6
author_role	author
author2	Sambo, M. (Marcel)\|\|\|/items/f2215404-a074-4696-9b4b-007eb5d92347 López-López, C. (Carlos)\|\|\|/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623 Duran-Poveda, M. (Manuel)\|\|\|/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3 Rodríguez-Villanueva, J. (Julio)\|\|\|/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8 Santos, R.J. (Rita Joana)\|\|\|/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5b Llanos, M. (Marta)\|\|\|/items/0729f342-59cf-48f6-bc21-4583b5c56ab4 Navarro-González, E. (Elena)\|\|\|/items/2a5ab034-b984-4db0-ac29-01769e51deb4 Aller, J. (Javier)\|\|\|/items/ec34b448-a292-40db-b68a-b6b7fc61fa12 Pubul, V. (Virginia)\|\|\|/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939 Guadalix, S. (Sonsoles)\|\|\|/items/59ca9666-3549-43be-b944-428d56084e83 Crespo, G. (Guillermo)\|\|\|/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fd González, C. (Cintia)\|\|\|/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2 Zafón, C. (Carles)\|\|\|/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47 Navarro-Martín, M. (Miguel)\|\|\|/items/ed497a9b-719a-4fe0-b55b-236687bb5e30 Santamaría-Sandi, J. (Javier)\|\|\|/items/527249b4-f47d-47c5-bd13-d511b652edfc Segura, Á. (Ángel)\|\|\|/items/67810931-6248-45e9-b582-3ca8a66c880e Gajate, P. (Pablo)\|\|\|/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3c Gómez-Balaguer, M. (Marcelino)\|\|\|/items/db41edd7-1409-4046-b379-b421c7839085 Valdivia, J. (Javier)\|\|\|/items/358fe79c-372e-4629-9bc5-e25d618fa8b3 Puig-Domingo, M. (Manel)\|\|\|/items/f5586785-d135-4265-b112-e266c12674ad Galofre-Ferrater, J.C. (Juan Carlos)\|\|\|/items/e7463ff9-97f4-4119-a307-fd978c0017fd Castelo, B. (Beatriz)\|\|\|/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43 Villanueva, M.J. (María José)\|\|\|/items/338926bd-47cc-4a27-a30a-53c3a05e0538 Argüelles, I. (Iñaki)\|\|\|/items/e398fe20-18b4-48ba-9d80-359c4437c374 Orcajo-Rincón, L. (Lorenzo)\|\|\|/items/cc08276f-fa02-4a05-997f-3fcc00a578e6
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Advanced differentiated thyroid cancer Epidemiological study Radioiodine-refractory differentiated thyroid cancer Relapsing differentiated thyroid cancer Relapsing prognostic factors Survival prognostic factors
topic	Advanced differentiated thyroid cancer Epidemiological study Radioiodine-refractory differentiated thyroid cancer Relapsing differentiated thyroid cancer Relapsing prognostic factors Survival prognostic factors
description	Background: Up to 30% of differentiated thyroid cancer (DTC) will develop advanced-stage disease (aDTC) with reduced overall survival (OS). Objective: The aim of this study is to characterize initial diagnosis of aDTC, its therapeutic management, and prognosis in Spain and Portugal. Methods: A multicentre, longitudinal, retrospective study of adult patients diagnosed with aDTC in the Iberian Peninsula was conducted between January 2007 and December 2012. Analyses of baseline characteristics and results of initial treatments, relapse- or progression-free survival ((RP)FS) from first DTC diagnosis, OS, and prognostic factors impacting the evolution of advanced disease were evaluated. Results: Two hundred and thirteen patients (median age: 63 years; 57% female) were eligible from 23 hospitals. Advanced disease presented at first diagnosis (de novo aDTC) included 54% of patients, while 46% had relapsed from early disease (recurrent/progressive eDTC). At initial stage, most patients received surgery (98%) and/or radioiodine (RAI) (89%), with no differences seen between median OS (95% CI) (10.4 (7.3-15.3) years) and median disease-specific-survival (95% CI) (11.1 (8.7-16.2) years; log-rank test P = 0.4737). Age at diagnosis being <55 years was associated with a lower risk of death (Wald chi-square (Wc-s) P < 0.0001), while a poor response to RAI to a higher risk of death ((Wc-s) P < 0.05). In the eDTC cohort, median (RP)FS (95% CI) was of 1.7 (1.0-2.0) years after RAI, with R0/R1 surgeries being the only common significant favourable factor for longer (RP)FS and time to aDTC ((Wc-s) P < 0.05). Conclusion: Identification of early treatment-dependent prognostic factors for an unfavourable course of advanced disease is possible. An intensified therapeutic attitude may reverse this trend and should be considered in poor-performing patients. Prospective studies are required to confirm these findings.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122399
url	https://hdl.handle.net/10171/122399
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Bioscientifica Ltd.
publisher.none.fl_str_mv	Bioscientifica Ltd.
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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spelling	Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT studyVallejo-Casas, J.A. (Juan Antonio)\|\|\|/items/663861ec-49dd-4b16-a21f-9d775d2ec84eSambo, M. (Marcel)\|\|\|/items/f2215404-a074-4696-9b4b-007eb5d92347López-López, C. (Carlos)\|\|\|/items/44b05f22-f7ad-4f5a-9d68-10fac9ccb623Duran-Poveda, M. (Manuel)\|\|\|/items/2958c567-ecb1-4d0e-bb4b-524e7753c8f3Rodríguez-Villanueva, J. (Julio)\|\|\|/items/1c9eeaac-bfac-471a-b03b-c75401a1b4f8Santos, R.J. (Rita Joana)\|\|\|/items/698a67e6-d2ae-4a1f-98fa-016f2678ca5bLlanos, M. (Marta)\|\|\|/items/0729f342-59cf-48f6-bc21-4583b5c56ab4Navarro-González, E. (Elena)\|\|\|/items/2a5ab034-b984-4db0-ac29-01769e51deb4Aller, J. (Javier)\|\|\|/items/ec34b448-a292-40db-b68a-b6b7fc61fa12Pubul, V. (Virginia)\|\|\|/items/a2690265-bed0-4ca8-8a7d-ad4b1587e939Guadalix, S. (Sonsoles)\|\|\|/items/59ca9666-3549-43be-b944-428d56084e83Crespo, G. (Guillermo)\|\|\|/items/0a956c2d-2ab1-46ca-bd33-c7a904a8c5fdGonzález, C. (Cintia)\|\|\|/items/a504da25-d8e2-45c3-b2a9-54d5e9d5cfc2Zafón, C. (Carles)\|\|\|/items/25a3e6e5-617d-4937-b3ce-7fed784dbb47Navarro-Martín, M. (Miguel)\|\|\|/items/ed497a9b-719a-4fe0-b55b-236687bb5e30Santamaría-Sandi, J. (Javier)\|\|\|/items/527249b4-f47d-47c5-bd13-d511b652edfcSegura, Á. (Ángel)\|\|\|/items/67810931-6248-45e9-b582-3ca8a66c880eGajate, P. (Pablo)\|\|\|/items/f452bc8c-3bb6-46ec-b249-41f4b596ee3cGómez-Balaguer, M. (Marcelino)\|\|\|/items/db41edd7-1409-4046-b379-b421c7839085Valdivia, J. (Javier)\|\|\|/items/358fe79c-372e-4629-9bc5-e25d618fa8b3Puig-Domingo, M. (Manel)\|\|\|/items/f5586785-d135-4265-b112-e266c12674adGalofre-Ferrater, J.C. (Juan Carlos)\|\|\|/items/e7463ff9-97f4-4119-a307-fd978c0017fdCastelo, B. (Beatriz)\|\|\|/items/7ac3977c-6dd5-463e-bb5f-a7f0cf681c43Villanueva, M.J. (María José)\|\|\|/items/338926bd-47cc-4a27-a30a-53c3a05e0538Argüelles, I. (Iñaki)\|\|\|/items/e398fe20-18b4-48ba-9d80-359c4437c374Orcajo-Rincón, L. (Lorenzo)\|\|\|/items/cc08276f-fa02-4a05-997f-3fcc00a578e6Advanced differentiated thyroid cancerEpidemiological studyRadioiodine-refractory differentiated thyroid cancerRelapsing differentiated thyroid cancerRelapsing prognostic factorsSurvival prognostic factorsBackground: Up to 30% of differentiated thyroid cancer (DTC) will develop advanced-stage disease (aDTC) with reduced overall survival (OS). Objective: The aim of this study is to characterize initial diagnosis of aDTC, its therapeutic management, and prognosis in Spain and Portugal. Methods: A multicentre, longitudinal, retrospective study of adult patients diagnosed with aDTC in the Iberian Peninsula was conducted between January 2007 and December 2012. Analyses of baseline characteristics and results of initial treatments, relapse- or progression-free survival ((RP)FS) from first DTC diagnosis, OS, and prognostic factors impacting the evolution of advanced disease were evaluated. Results: Two hundred and thirteen patients (median age: 63 years; 57% female) were eligible from 23 hospitals. Advanced disease presented at first diagnosis (de novo aDTC) included 54% of patients, while 46% had relapsed from early disease (recurrent/progressive eDTC). At initial stage, most patients received surgery (98%) and/or radioiodine (RAI) (89%), with no differences seen between median OS (95% CI) (10.4 (7.3-15.3) years) and median disease-specific-survival (95% CI) (11.1 (8.7-16.2) years; log-rank test P = 0.4737). Age at diagnosis being <55 years was associated with a lower risk of death (Wald chi-square (Wc-s) P < 0.0001), while a poor response to RAI to a higher risk of death ((Wc-s) P < 0.05). In the eDTC cohort, median (RP)FS (95% CI) was of 1.7 (1.0-2.0) years after RAI, with R0/R1 surgeries being the only common significant favourable factor for longer (RP)FS and time to aDTC ((Wc-s) P < 0.05). Conclusion: Identification of early treatment-dependent prognostic factors for an unfavourable course of advanced disease is possible. An intensified therapeutic attitude may reverse this trend and should be considered in poor-performing patients. Prospective studies are required to confirm these findings.Bioscientifica Ltd.Dadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122399reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1223992026-06-21T12:47:57Z
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Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study

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