Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents

Objective: Exposure to extreme temperatures has been linked to acute mental health events in young populations, but the underlying neural mechanisms are not well understood. Resting-state functional magnetic resonance imaging allows for the assessment of connectivity patterns in brain functional net...

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Autores: Granés, Laura, Kusters, Michelle S.W., Ballester, Joan, Essers, Esmée, Petricola, Sami, López Vicente, Mònica, Soriano Mas, Carles, Guxens, Mònica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226922
Acceso en línea:https://hdl.handle.net/2445/226922
Access Level:acceso abierto
Palabra clave:Escorça frontal
Temperatures baixes (Investigació)
Neurofisiologia
Prefrontal cortex
Low temperature research
Neurophysiology
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spelling Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in PreadolescentsGranés, LauraKusters, Michelle S.W.Ballester, JoanEssers, EsméePetricola, SamiLópez Vicente, Mònica Soriano Mas, Carles Guxens, MònicaEscorça frontalTemperatures baixes (Investigació)NeurofisiologiaPrefrontal cortexLow temperature researchNeurophysiologyObjective: Exposure to extreme temperatures has been linked to acute mental health events in young populations, but the underlying neural mechanisms are not well understood. Resting-state functional magnetic resonance imaging allows for the assessment of connectivity patterns in brain functional networks, which have been associated with mental health disorders. This study investigated the short-term effects of ambient temperature on functional connectivity of brain resting-state networks in preadolescents. Method: The study was embedded in the Generation R Study, Rotterdam, the Netherlands. Daily mean temperature estimates at the residential addresses of participants were obtained from a high-resolution urban climate model (UrbClim). Resting-state functional connectivity data were assessed with brain magnetic resonance images of 2,229 children ages 9 to 12 years. Distributed lag nonlinear models were fitted to assess the cumulative effects of temperature during the week before the brain scan on within- and between-network connectivity of 15 resting-state networks. Results: Higher ambient temperature during the week before the imaging assessment was associated with lower functional connectivity within the medial parietal, salience, and hippocampus networks. The effect was highest the day before the brain scan and progressively decayed in the preceding days. Lower temperatures were not related to functional connectivity. Conclusion: Exposure to high ambient temperatures over a 7-day period was associated with lower within-network connectivity in preadolescents, suggesting impacts of heat on brain function. These findings raise new research questions on whether decreases in functional connectivity within the salience network may partially explain the association between high temperatures and suicide rates previously reported in the literature. Plain language summary: Exposure to extreme temperatures has been linked to acute mental health events in young populations, but the underlying neural mechanisms are not well understood. Utilizing data from 2,229 children aged 9 to 12 years who participated in the Generation R Study, Rotterdam (n = 2,229 children aged 9-12 years), the authors examined the relationships between brain scan results and temperature exposure at children's residential address the week prior to the brain scan. Children exposed to higher ambient temperatures over the week prior to the brain scan had lower functional connectivity in some brain regions, whereas lower temperatures were not associated with changes in connectivity. These findings suggest that warmer ambient temperatures may affect brain function in preadolescents.Elsevier BV2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/226922Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.jaac.2024.11.023Journal of the American Academy of Child & Adolescent Psychiatry, 2025, vol. 64, num. 11, 1317-1328https://doi.org/10.1016/j.jaac.2024.11.023cc-by (c) American Academy of Child and Adolescent Psychiatry, 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2269222026-05-27T06:46:51Z
dc.title.none.fl_str_mv Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
title Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
spellingShingle Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
Granés, Laura
Escorça frontal
Temperatures baixes (Investigació)
Neurofisiologia
Prefrontal cortex
Low temperature research
Neurophysiology
title_short Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
title_full Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
title_fullStr Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
title_full_unstemmed Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
title_sort Exposure to Ambient Temperature and Functional Connectivity of Brain Resting-State Networks in Preadolescents
dc.creator.none.fl_str_mv Granés, Laura
Kusters, Michelle S.W.
Ballester, Joan
Essers, Esmée
Petricola, Sami
López Vicente, Mònica
Soriano Mas, Carles
Guxens, Mònica
author Granés, Laura
author_facet Granés, Laura
Kusters, Michelle S.W.
Ballester, Joan
Essers, Esmée
Petricola, Sami
López Vicente, Mònica
Soriano Mas, Carles
Guxens, Mònica
author_role author
author2 Kusters, Michelle S.W.
Ballester, Joan
Essers, Esmée
Petricola, Sami
López Vicente, Mònica
Soriano Mas, Carles
Guxens, Mònica
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Escorça frontal
Temperatures baixes (Investigació)
Neurofisiologia
Prefrontal cortex
Low temperature research
Neurophysiology
topic Escorça frontal
Temperatures baixes (Investigació)
Neurofisiologia
Prefrontal cortex
Low temperature research
Neurophysiology
description Objective: Exposure to extreme temperatures has been linked to acute mental health events in young populations, but the underlying neural mechanisms are not well understood. Resting-state functional magnetic resonance imaging allows for the assessment of connectivity patterns in brain functional networks, which have been associated with mental health disorders. This study investigated the short-term effects of ambient temperature on functional connectivity of brain resting-state networks in preadolescents. Method: The study was embedded in the Generation R Study, Rotterdam, the Netherlands. Daily mean temperature estimates at the residential addresses of participants were obtained from a high-resolution urban climate model (UrbClim). Resting-state functional connectivity data were assessed with brain magnetic resonance images of 2,229 children ages 9 to 12 years. Distributed lag nonlinear models were fitted to assess the cumulative effects of temperature during the week before the brain scan on within- and between-network connectivity of 15 resting-state networks. Results: Higher ambient temperature during the week before the imaging assessment was associated with lower functional connectivity within the medial parietal, salience, and hippocampus networks. The effect was highest the day before the brain scan and progressively decayed in the preceding days. Lower temperatures were not related to functional connectivity. Conclusion: Exposure to high ambient temperatures over a 7-day period was associated with lower within-network connectivity in preadolescents, suggesting impacts of heat on brain function. These findings raise new research questions on whether decreases in functional connectivity within the salience network may partially explain the association between high temperatures and suicide rates previously reported in the literature. Plain language summary: Exposure to extreme temperatures has been linked to acute mental health events in young populations, but the underlying neural mechanisms are not well understood. Utilizing data from 2,229 children aged 9 to 12 years who participated in the Generation R Study, Rotterdam (n = 2,229 children aged 9-12 years), the authors examined the relationships between brain scan results and temperature exposure at children's residential address the week prior to the brain scan. Children exposed to higher ambient temperatures over the week prior to the brain scan had lower functional connectivity in some brain regions, whereas lower temperatures were not associated with changes in connectivity. These findings suggest that warmer ambient temperatures may affect brain function in preadolescents.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226922
url https://hdl.handle.net/2445/226922
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.jaac.2024.11.023
Journal of the American Academy of Child & Adolescent Psychiatry, 2025, vol. 64, num. 11, 1317-1328
https://doi.org/10.1016/j.jaac.2024.11.023
dc.rights.none.fl_str_mv cc-by (c) American Academy of Child and Adolescent Psychiatry, 2025
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) American Academy of Child and Adolescent Psychiatry, 2025
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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