Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020

Introduction: To assess time trends in incidence, clinical characteristics, complications, and hospital outcomes among patients with type 1 diabetes (T1D), with type 2 diabetes (T2D), and patients without diabetes who underwent kidney transplant (KT); to identify variables associated with in-hospita...

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Autores: López De Andrés, Ana Isabel, Jiménez García, Rodrigo, López Herranz, Marta, Zamorano León, José Javier, Carabantes Alarcón, David, Hernández Barrera, Valentín, Miguel Díez, Javier De, Carricondo Orejana, Francisco Javier, Romero Gómez, Bárbara, Cuadrado Corrales, María Natividad
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/115139
Acceso en línea:https://hdl.handle.net/20.500.14352/115139
Access Level:acceso abierto
Palabra clave:578.834:616.98
616.98:578.834
COVID-19
Incidence
Kidney Transplantation
Type 2 Diabetes
Ciencias Biomédicas
Salud pública (Medicina)
32 Ciencias Médicas
3212 Salud Publica
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020López De Andrés, Ana IsabelJiménez García, RodrigoLópez Herranz, MartaZamorano León, José JavierCarabantes Alarcón, DavidHernández Barrera, ValentínMiguel Díez, Javier DeCarricondo Orejana, Francisco JavierRomero Gómez, BárbaraCuadrado Corrales, María Natividad578.834:616.98616.98:578.834COVID-19IncidenceKidney TransplantationType 2 DiabetesCiencias BiomédicasSalud pública (Medicina)32 Ciencias Médicas3212 Salud PublicaIntroduction: To assess time trends in incidence, clinical characteristics, complications, and hospital outcomes among patients with type 1 diabetes (T1D), with type 2 diabetes (T2D), and patients without diabetes who underwent kidney transplant (KT); to identify variables associated with in-hospital mortality (IHM); and to determine the impact of the COVID-19 pandemic. Research design and methods: We used a nationwide discharge database to select KT recipients admitted to Spanish hospitals from 2016 to 2020. We stratified patients according to diabetes status. We used multivariable logistic regression to identify the variables associated with IHM. Results: A total of 14 594 KTs were performed in Spain (T2D, 22.28%; T1D, 3.72%). The number of KTs rose between 2016 and 2019 and and decreased from 2019 to 2020 in all groups. In patients with T2D, the frequency of KT complications increased from 21.08% in 2016 to 34.17% in 2020 (p<0.001). Patients with T2D had significantly more comorbidity than patients with T1D and patients without diabetes (p<0.001). Patients with T1D experienced KT rejection significantly more frequently (8.09%) than patients with T2D (5.57%).COVID-19 was recorded in 26 out of the 2444 KTs performed in 2020, being found in 6 of the 39 patients deceased that year (15.38%) and in 0.83% of the survivors.The variables associated with IHM were comorbidity and complications of KT. The presence of T1D was associated with IHM (OR 2.6; 95% CI 1.36 to 5.16) when patients without diabetes were the reference category. However, T2D was not associated with a higher IHM (OR 0.86; 95% CI 0.61 to 1.2). Conclusions: The COVID-19 pandemic led to a decrease in the number of transplants. Patients with T1D have more rejection of the transplanted organ than patients with T2D. Fewer women with T2D undergo KT. The presence of T1D is a risk factor for IHM.BMJ Publishing GroupUniversidad Complutense de Madrid20242024-04-0320242024-04-03journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/115139reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1151392026-06-02T12:44:21Z
dc.title.none.fl_str_mv Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
title Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
spellingShingle Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
López De Andrés, Ana Isabel
578.834:616.98
616.98:578.834
COVID-19
Incidence
Kidney Transplantation
Type 2 Diabetes
Ciencias Biomédicas
Salud pública (Medicina)
32 Ciencias Médicas
3212 Salud Publica
title_short Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
title_full Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
title_fullStr Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
title_full_unstemmed Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
title_sort Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
dc.creator.none.fl_str_mv López De Andrés, Ana Isabel
Jiménez García, Rodrigo
López Herranz, Marta
Zamorano León, José Javier
Carabantes Alarcón, David
Hernández Barrera, Valentín
Miguel Díez, Javier De
Carricondo Orejana, Francisco Javier
Romero Gómez, Bárbara
Cuadrado Corrales, María Natividad
author López De Andrés, Ana Isabel
author_facet López De Andrés, Ana Isabel
Jiménez García, Rodrigo
López Herranz, Marta
Zamorano León, José Javier
Carabantes Alarcón, David
Hernández Barrera, Valentín
Miguel Díez, Javier De
Carricondo Orejana, Francisco Javier
Romero Gómez, Bárbara
Cuadrado Corrales, María Natividad
author_role author
author2 Jiménez García, Rodrigo
López Herranz, Marta
Zamorano León, José Javier
Carabantes Alarcón, David
Hernández Barrera, Valentín
Miguel Díez, Javier De
Carricondo Orejana, Francisco Javier
Romero Gómez, Bárbara
Cuadrado Corrales, María Natividad
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 578.834:616.98
616.98:578.834
COVID-19
Incidence
Kidney Transplantation
Type 2 Diabetes
Ciencias Biomédicas
Salud pública (Medicina)
32 Ciencias Médicas
3212 Salud Publica
topic 578.834:616.98
616.98:578.834
COVID-19
Incidence
Kidney Transplantation
Type 2 Diabetes
Ciencias Biomédicas
Salud pública (Medicina)
32 Ciencias Médicas
3212 Salud Publica
description Introduction: To assess time trends in incidence, clinical characteristics, complications, and hospital outcomes among patients with type 1 diabetes (T1D), with type 2 diabetes (T2D), and patients without diabetes who underwent kidney transplant (KT); to identify variables associated with in-hospital mortality (IHM); and to determine the impact of the COVID-19 pandemic. Research design and methods: We used a nationwide discharge database to select KT recipients admitted to Spanish hospitals from 2016 to 2020. We stratified patients according to diabetes status. We used multivariable logistic regression to identify the variables associated with IHM. Results: A total of 14 594 KTs were performed in Spain (T2D, 22.28%; T1D, 3.72%). The number of KTs rose between 2016 and 2019 and and decreased from 2019 to 2020 in all groups. In patients with T2D, the frequency of KT complications increased from 21.08% in 2016 to 34.17% in 2020 (p<0.001). Patients with T2D had significantly more comorbidity than patients with T1D and patients without diabetes (p<0.001). Patients with T1D experienced KT rejection significantly more frequently (8.09%) than patients with T2D (5.57%).COVID-19 was recorded in 26 out of the 2444 KTs performed in 2020, being found in 6 of the 39 patients deceased that year (15.38%) and in 0.83% of the survivors.The variables associated with IHM were comorbidity and complications of KT. The presence of T1D was associated with IHM (OR 2.6; 95% CI 1.36 to 5.16) when patients without diabetes were the reference category. However, T2D was not associated with a higher IHM (OR 0.86; 95% CI 0.61 to 1.2). Conclusions: The COVID-19 pandemic led to a decrease in the number of transplants. Patients with T1D have more rejection of the transplanted organ than patients with T2D. Fewer women with T2D undergo KT. The presence of T1D is a risk factor for IHM.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-04-03
2024
2024-04-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/115139
url https://hdl.handle.net/20.500.14352/115139
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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