Enzyme-powered hollow mesoporous Janus nanomotors

The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-pr...

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Autores: Ma, Xing, Jannasch, Anita, Albrecth, Urban-Raphael, Hahn, Kersten, Miguel López, Albert, Schäffer, Erik, Sánchez Ordóñez, Samuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/123491
Acceso en línea:https://hdl.handle.net/2445/123491
Access Level:acceso abierto
Palabra clave:Sílice
Nanopartícules
Enzims
Silica
Nanoparticles
Enzymes
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spelling Enzyme-powered hollow mesoporous Janus nanomotorsMa, XingJannasch, AnitaAlbrecth, Urban-RaphaelHahn, KerstenMiguel López, AlbertSchäffer, ErikSánchez Ordóñez, SamuelSíliceNanopartículesEnzimsSilicaNanoparticlesEnzymesThe development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.American Chemical Society201820182015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/123491Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1021/acs.nanolett.5b03100Nano Letters, 2015, vol. 15, num. 10, p. 7043-7050http://dx.doi.org/10.1021/acs.nanolett.5b03100info:eu-repo/grantAgreement/EC/FP7/311529(c) American Chemical Society, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1234912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Enzyme-powered hollow mesoporous Janus nanomotors
title Enzyme-powered hollow mesoporous Janus nanomotors
spellingShingle Enzyme-powered hollow mesoporous Janus nanomotors
Ma, Xing
Sílice
Nanopartícules
Enzims
Silica
Nanoparticles
Enzymes
title_short Enzyme-powered hollow mesoporous Janus nanomotors
title_full Enzyme-powered hollow mesoporous Janus nanomotors
title_fullStr Enzyme-powered hollow mesoporous Janus nanomotors
title_full_unstemmed Enzyme-powered hollow mesoporous Janus nanomotors
title_sort Enzyme-powered hollow mesoporous Janus nanomotors
dc.creator.none.fl_str_mv Ma, Xing
Jannasch, Anita
Albrecth, Urban-Raphael
Hahn, Kersten
Miguel López, Albert
Schäffer, Erik
Sánchez Ordóñez, Samuel
author Ma, Xing
author_facet Ma, Xing
Jannasch, Anita
Albrecth, Urban-Raphael
Hahn, Kersten
Miguel López, Albert
Schäffer, Erik
Sánchez Ordóñez, Samuel
author_role author
author2 Jannasch, Anita
Albrecth, Urban-Raphael
Hahn, Kersten
Miguel López, Albert
Schäffer, Erik
Sánchez Ordóñez, Samuel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Sílice
Nanopartícules
Enzims
Silica
Nanoparticles
Enzymes
topic Sílice
Nanopartícules
Enzims
Silica
Nanoparticles
Enzymes
description The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/123491
url https://hdl.handle.net/2445/123491
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1021/acs.nanolett.5b03100
Nano Letters, 2015, vol. 15, num. 10, p. 7043-7050
http://dx.doi.org/10.1021/acs.nanolett.5b03100
info:eu-repo/grantAgreement/EC/FP7/311529
dc.rights.none.fl_str_mv (c) American Chemical Society, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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