Double fingerprint characterization of uracil and 5-fluorouracil

Time Resolved Raman spectroelectrochemistry (TR-Raman-SEC) has been used for the first time to obtain two different Raman spectra of one single analyte in the same experiment. This double detection has been accomplished thanks to the use of electrochemical surface enhanced Raman scattering (EC-SERS)...

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Autores: Pérez Estébanez, Martín, Cheuquepan Valenzuela, William, Cuevas Vicario, José Vicente, Hernández Muñoz, Sheila, Heras Vidaurre, Aránzazu, Colina Santamaría, Álvaro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/10052
Acceso en línea:http://hdl.handle.net/10259/10052
Access Level:acceso abierto
Palabra clave:Spectroelectrochemistry
Raman
EC-SERS
EC-SOERS
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
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spelling Double fingerprint characterization of uracil and 5-fluorouracilPérez Estébanez, MartínCheuquepan Valenzuela, WilliamCuevas Vicario, José VicenteHernández Muñoz, SheilaHeras Vidaurre, AránzazuColina Santamaría, ÁlvaroSpectroelectrochemistryRamanEC-SERSEC-SOERSQuímica analíticaElectroquímicaChemistry, AnalyticElectrochemistryTime Resolved Raman spectroelectrochemistry (TR-Raman-SEC) has been used for the first time to obtain two different Raman spectra of one single analyte in the same experiment. This double detection has been accomplished thanks to the use of electrochemical surface enhanced Raman scattering (EC-SERS) and electrochemical surface oxidation enhanced Raman scattering (EC-SOERS) in the same experiment. These two Raman enhancement phenomena can provide a broad insight into the interaction between analyte and substrate surface when they are combined. To prove the possibilities of this methodology, a Raman spectroelectrochemistry study of uracil (U) and 5-fluorouracil (5-FU), two analytes with relevance in medicine and biochemistry, have been performed. Density functional theory (DFT) calculations has been carried out to shed more light on the interaction of these molecules with silver substrates in acidic media.Authors acknowledge the financial support from Ministerio de Economía, y Competitividad (Grant CTQ2017–83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18, Grant BU087G19, and Grant BU263P18) and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018–102412-T and Grant PID2019–111215RB-I00). W. Ch. thanks JCyL for his postdoctoral fellowship (Grant BU297P18). S.H. thanks JCyL and European Social Fund for her predoctoral fellowship. M.P-E. thanks JCyL, the European Social Fund and the Youth Employment initiative and JCyL and European Social Fund for his predoctoral fellowship. This research has made use of the high-performance computing resources of the Castilla y León Supercomputing Center (SCAYLE, https://www.scayle.es), financed by FEDER (Fondo Europeo de Desarrollo Regional). Jorge Gonzalez is acknowledged for his help in the laboratory whose contract was founded by JCyL, the European Social Fund and the Youth Employment Initiative.Elsevier202520252021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/10052reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésElectrochimica Acta. 2021, V. 388, 138615https://doi.org/10.1016/j.electacta.2021.138615Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/100522026-05-28T07:56:11Z
dc.title.none.fl_str_mv Double fingerprint characterization of uracil and 5-fluorouracil
title Double fingerprint characterization of uracil and 5-fluorouracil
spellingShingle Double fingerprint characterization of uracil and 5-fluorouracil
Pérez Estébanez, Martín
Spectroelectrochemistry
Raman
EC-SERS
EC-SOERS
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
title_short Double fingerprint characterization of uracil and 5-fluorouracil
title_full Double fingerprint characterization of uracil and 5-fluorouracil
title_fullStr Double fingerprint characterization of uracil and 5-fluorouracil
title_full_unstemmed Double fingerprint characterization of uracil and 5-fluorouracil
title_sort Double fingerprint characterization of uracil and 5-fluorouracil
dc.creator.none.fl_str_mv Pérez Estébanez, Martín
Cheuquepan Valenzuela, William
Cuevas Vicario, José Vicente
Hernández Muñoz, Sheila
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author Pérez Estébanez, Martín
author_facet Pérez Estébanez, Martín
Cheuquepan Valenzuela, William
Cuevas Vicario, José Vicente
Hernández Muñoz, Sheila
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author_role author
author2 Cheuquepan Valenzuela, William
Cuevas Vicario, José Vicente
Hernández Muñoz, Sheila
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Spectroelectrochemistry
Raman
EC-SERS
EC-SOERS
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
topic Spectroelectrochemistry
Raman
EC-SERS
EC-SOERS
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
description Time Resolved Raman spectroelectrochemistry (TR-Raman-SEC) has been used for the first time to obtain two different Raman spectra of one single analyte in the same experiment. This double detection has been accomplished thanks to the use of electrochemical surface enhanced Raman scattering (EC-SERS) and electrochemical surface oxidation enhanced Raman scattering (EC-SOERS) in the same experiment. These two Raman enhancement phenomena can provide a broad insight into the interaction between analyte and substrate surface when they are combined. To prove the possibilities of this methodology, a Raman spectroelectrochemistry study of uracil (U) and 5-fluorouracil (5-FU), two analytes with relevance in medicine and biochemistry, have been performed. Density functional theory (DFT) calculations has been carried out to shed more light on the interaction of these molecules with silver substrates in acidic media.
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/10052
url http://hdl.handle.net/10259/10052
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Electrochimica Acta. 2021, V. 388, 138615
https://doi.org/10.1016/j.electacta.2021.138615
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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